Gallstone Disease: Scientific Understanding and Future Treatment

  • Frank LammertEmail author


Gallstones are a widespread disease caused by interaction of exogenous and genetic risk factors. The most frequent stones are cholesterol gallbladder stones, which are a consequence of increased hepatic secretion into bile. Multiple genetic factors confer gallstone risk, with the largest effect contributed by a common variant of the hepatic cholesterol transporter ABCG8. A distinct subgroup of patients develops gallstones due to low phosphatidylcholine concentrations in bile, which is caused by ABCB4 transporter defects. Later in the twenty first century, general lifestyle interventions and precise molecular prevention might overcome the current invasive therapy of gallstone disease with cholecystectomy.


Laparoscopic Cholecystectomy Cystic Fibrosis Transmembrane Conductance Regulator Bile Duct Stone Gallstone Disease Gallstone Formation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Department of Medicine IISaarland University Medical Center, Saarland UniversityHomburgGermany

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