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Wrestling with Chromosomes: The Roles of SUMO During Meiosis

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Book cover SUMO Regulation of Cellular Processes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 963))

Abstract

Meiosis is a specialized form of cell division required for the formation of haploid gametes and therefore is essential for successful sexual reproduction. Various steps are exquisitely coordinated to ensure accurate chromosome segregation during meiosis, thereby promoting the formation of haploid gametes from diploid cells. Recent studies are demonstrating that an important form of regulation during meiosis is exerted by the post-translational protein modification known as sumoylation. Here, we review and discuss the various critical steps of meiosis in which SUMO-mediated regulation has been implicated thus far. These include the maintenance of meiotic centromeric heterochromatin , meiotic DNA double-strand break repair and homologous recombination, centromeric coupling, and the assembly of a proteinaceous scaffold between homologous chromosomes known as the synaptonemal complex.

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Acknowledgements

Our research is supported by grants from the National Institutes of Health (R01GM072551 and R01GM105853 to M.P.C.) and the Kafker Family Research Fund.

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Authors and Affiliations

  1. Department of Genetics, Harvard Medical School, Boston, MA, 02115, USA

    Amanda C. Nottke, Hyun-Min Kim & Monica P. Colaiácovo

  2. Department of Pathology, Harvard Medical School, Boston, MA, 02115, USA

    Amanda C. Nottke

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  1. Amanda C. Nottke
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  2. Hyun-Min Kim
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  3. Monica P. Colaiácovo
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Correspondence to Monica P. Colaiácovo .

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Editors and Affiliations

  1. Department of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M Health Science Center, Bryan, Texas, USA

    Van G. Wilson

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Nottke, A.C., Kim, HM., Colaiácovo, M.P. (2017). Wrestling with Chromosomes: The Roles of SUMO During Meiosis. In: Wilson, V. (eds) SUMO Regulation of Cellular Processes. Advances in Experimental Medicine and Biology, vol 963. Springer, Cham. https://doi.org/10.1007/978-3-319-50044-7_11

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