Abstract
Swept source optical coherence tomography angiography (SS-OCTA) devices are the latest OCT technology to become commercially available. These units feature scan rates of 100,000 A-scans per second. In this chapter, the use of an ultra-high speed SS-OCTA prototype device developed at Massachusetts Institute of Technology (Cambridge, MA, USA) and deployed to New England Eye Center, Boston, MA will be discussed. The prototype SS-OCT system has been described previously, so only key attributes are considered for the purposes of this chapter [1]. This device utilizes a vertical-cavity surface-emitting laser (VCSEL) with a light source operating at a 1050 nm wavelength and a scan rate of 400,000 A-scans per second. Images are obtained by acquiring five repeated B-scans from 500 sequentially uniformly spaced locations on the retina, with each B-scan consisting of 500 A-scans. Thus a total of 5 × 500 × 500 A-scans are acquired per SS-OCTA volume with a total acquisition time of approximately 3.8 s. The imaging range is approximately 2.1 mm in tissue, and the axial and transverse resolutions in tissue are approximately 8–9 μm and approximately 15 μm, respectively. A post-processing registration step merges the orthogonally scanned “X-fast” and “Y-fast” volumes to patient motion artifacts [2].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Novais EA, Adhi M, Moult EM, Louzada RN, Cole ED, Husvogt L, et al. Choroidal neovascularization analyzed on ultrahigh-speed swept-source optical coherence tomography angiography compared to spectral-domain optical coherence tomography angiography. Am J Ophthalmol. 2016;164:80–8.
Kraus MF, Potsaid B, Mayer MA, Bock R, Baumann B, Liu JJ, et al. Motion correction in optical coherence tomography volumes on a per A-scan basis using orthogonal scan patterns. Biomed Opt Express. 2012;3:1182–99.
Kraus MF, Liu JJ, Schottenhamml J, Chen CL, Budai A, Branchini L, et al. Quantitative 3D-OCT motion correction with tilt and illumination correction, robust similarity measure and regularization. Biomed Opt Express. 2014;5:2591–613.
Ota M, Tsujikawa A, Murakami T, Yamaike N, Sakamoto A, Kotera Y, et al. Foveal photoreceptor layer in eyes with persistent cystoid macular edema associated with branch retinal vein occlusion. Am J Ophthalmol. 2008;145:273–80.
Hayreh SS, Zimmerman MB. Fundus changes in branch retinal vein occlusion. Retina. 2015;35:1016–27.
Hayreh SS. Classification of central retinal vein occlusion. Ophthalmology. 1983;90:458–74.
Ferrara D, Waheed NK, Duker JS. Investigating the choriocapillaris and choroidal vasculature with new optical coherence tomography technologies. Prog Retin Eye Res. 2016;52:130–55. doi:10.1016/j.preteyeres.2015.10.002. Epub 2015 Oct 23
Seddon JM, Francis PJ, George S, Schultz DW, Rosner B, Klein ML. Association of CFH Y402H and LOC387715 A69S with progression of age-related macular degeneration. JAMA. 2007;297:1793–800.
Shah AR, Williams S, Baumal CR, Rosner B, Duker JS, Seddon JM. Predictors of response to intravitreal anti-vascular endothelial growth factor treatment of age-related macular degeneration. Am J Ophthalmol. 2016;163:154–66.e8.
Bhutto I, Lutty G. Understanding age-related macular degeneration (AMD): relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex. Mol Asp Med. 2012;33:295–317.
Lutty G, Grunwald J, Majji AB, Uyama M, Yoneya S. Changes in choriocapillaris and retinal pigment epithelium in age-related macular degeneration. Mol Vis. 1999;5:35.
McLeod DS, Grebe R, Bhutto I, Merges C, Baba T, Lutty GA. Relationship between RPE and choriocapillaris in age-related macular degeneration. Invest Ophthalmol Vis Sci. 2009;50:4982–91.
McLeod DS, Taomoto M, Otsuji T, Green WR, Sunness JS, Lutty GA. Quantifying changes in RPE and choroidal vasculature in eyes with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2002;43:1986–93.
Spaide RF, Campeas L, Haas A, Yannuzzi LA, Fisher YL, Guyer DR, et al. Central serous chorioretinopathy in younger and older adults. Ophthalmology. 1996;103:2070–9. discussion 9–80
Kitaya N, Nagaoka T, Hikichi T, Sugawara R, Fukui K, Ishiko S, et al. Features of abnormal choroidal circulation in central serous chorioretinopathy. Br J Ophthalmol. 2003;87:709–12.
Yannuzzi LA, Sorenson J, Spaide RF, Lipson B. Idiopathic polypoidal choroidal vasculopathy (IPCV). Retina. 1990;10:1–8.
Callanan DG, Lewis ML, Byrne SF, Gass JD. Choroidal neovascularization associated with choroidal nevi. Arch Ophthalmol. 1993;111:789–94.
Shields CL, Mashayekhi A, Materin MA, Luo CK, Marr BP, Demirci H, et al. Optical coherence tomography of choroidal nevus in 120 patients. Retina. 2005;25:243–52.
Acknowledgments
The authors gratefully acknowledge Eduardo Novais and Mark Lane for assistance with imaging; ByungKun Lee and Chen Lu and Jonathan Liu for developing the swept source technology; Benjamin Potsaid and Alex Cable from Thorlabs; Vijaysekhar Jayaraman from Praevium Research for developing VCSEL laser technology; and Stefan Ploner, Julia Schottenhamml, and Lennart Husvogt for developing the Pipeline and Vista software.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this chapter
Cite this chapter
Louzada, R.N., Moult, E.M., Cole, E., Fujimoto, J.G., Duker, J.S. (2017). Swept Source OCT Angiography in Different Diseases. In: Michalewska, Z., Nawrocki, J. (eds) Atlas of Swept Source Optical Coherence Tomography . Springer, Cham. https://doi.org/10.1007/978-3-319-49840-9_3
Download citation
DOI: https://doi.org/10.1007/978-3-319-49840-9_3
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-49839-3
Online ISBN: 978-3-319-49840-9
eBook Packages: MedicineMedicine (R0)