Skip to main content

Seizures and Status Epilepticus in Pediatric Critical Care

  • Chapter
  • First Online:
Seizures in Critical Care

Part of the book series: Current Clinical Neurology ((CCNEU))

  • 1810 Accesses

Abstract

Status epilepticus (SE) and seizures are common pediatric neurologic emergencies, yet management is highly variable and treatment delays have been reported. Rapid management is needed to manage systemic complications, identify and manage precipitating conditions, and terminate seizures. While evidence-based management data are limited, a predetermined management plan that emphasizes rapid progression through appropriately dosed antiseizure medications may help streamline and optimize management. Children with or without prior convulsive seizures may experience electrographic seizures requiring electroencephalographic monitoring for identification. This chapter reviews the identification and management of seizures and status epilepticus and the use of electroencephalographic monitoring among children in the pediatric intensive care unit.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 139.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Bell MJ, Carpenter J, Au AK, Keating RF, Myseros JS, Yaun A, et al. Development of a pediatric neurocritical care service. Neurocrit Care. 2008;10(1):4–10.

    Article  Google Scholar 

  2. LaRovere KL, Graham RJ, Tasker RC. Pediatric neurocritical care: a neurology consultation model and implication for education and training. Pediatr Neurol. 2013;48(3):206–11.

    Article  PubMed  Google Scholar 

  3. Sanchez Fernandez I, Abend NS, Agadi S, An S, Arya R, Brenton JN, et al. Time from convulsive status epilepticus onset to anticonvulsant administration in children. Neurology. 2015;84(23):2304–11.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Chin RF, Verhulst L, Neville BG, Peters MJ, Scott RC. Inappropriate emergency management of status epilepticus in children contributes to need for intensive care. J Neurol Neurosurg Psychiatry. 2004;75(11):1584–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Tirupathi S, McMenamin JB, Webb DW. Analysis of factors influencing admission to intensive care following convulsive status epilepticus in children. Seizure. 2009;18(9):630–3.

    Article  PubMed  Google Scholar 

  6. Tobias JD, Berkenbosch JW. Management of status epilepticus in infants and children prior to pediatric ICU admission: deviations from the current guidelines. South Med J. 2008;101(3):268–72.

    Article  PubMed  Google Scholar 

  7. Abend NS, Wusthoff CJ, Goldberg EM, Dlugos DJ. Electrographic seizures and status epilepticus in critically ill children and neonates with encephalopathy. Lancet Neurol. 2013;12(12):1170–9.

    Article  PubMed  Google Scholar 

  8. Hosain SA, Solomon GE, Kobylarz EJ. Electroencephalographic patterns in unresponsive pediatric patients. Pediatr Neurol. 2005;32(3):162–5.

    Article  PubMed  Google Scholar 

  9. Jette N, Claassen J, Emerson RG, Hirsch LJ. Frequency and predictors of nonconvulsive seizures during continuous electroencephalographic monitoring in critically ill children. Arch Neurol. 2006;63(12):1750–5.

    Article  PubMed  Google Scholar 

  10. Abend NS, Dlugos DJ. Nonconvulsive status epilepticus in a pediatric intensive care unit. Pediatr Neurol. 2007;37(3):165–70.

    Article  PubMed  Google Scholar 

  11. Tay SK, Hirsch LJ, Leary L, Jette N, Wittman J, Akman CI. Nonconvulsive status epilepticus in children: clinical and EEG characteristics. Epilepsia. 2006;47(9):1504–9.

    Article  PubMed  Google Scholar 

  12. Shahwan A, Bailey C, Shekerdemian L, Harvey AS. The prevalence of seizures in comatose children in the pediatric intensive care unit: a prospective video-EEG study. Epilepsia. 2010;51(7):1198–204.

    Article  PubMed  Google Scholar 

  13. Abend NS, Topjian A, Ichord R, Herman ST, Helfaer M, Donnelly M, et al. Electroencephalographic monitoring during hypothermia after pediatric cardiac arrest. Neurology. 2009;72(22):1931–40.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Williams K, Jarrar R, Buchhalter J. Continuous video-EEG monitoring in pediatric intensive care units. Epilepsia. 2011;52(6):1130–6.

    Article  PubMed  Google Scholar 

  15. Greiner HM, Holland K, Leach JL, Horn PS, Hershey AD, Rose DF. Nonconvulsive status epilepticus: the encephalopathic pediatric patient. Pediatrics. 2012;129(3):e748–55.

    Article  PubMed  Google Scholar 

  16. Kirkham FJ, Wade AM, McElduff F, Boyd SG, Tasker RC, Edwards M, et al. Seizures in 204 comatose children: incidence and outcome. Intensive Care Med. 2012;38(5):853–62.

    Article  PubMed  PubMed Central  Google Scholar 

  17. Arango JI, Deibert CP, Brown D, Bell M, Dvorchik I, Adelson PD. Posttraumatic seizures in children with severe traumatic brain injury. Childs Nerv Syst. 2012;28(11):1925–9.

    Article  PubMed  Google Scholar 

  18. Piantino JA, Wainwright MS, Grimason M, Smith CM, Hussain E, Byron D, et al. Nonconvulsive seizures are common in children treated with extracorporeal cardiac life support. Pediatr Crit Care Med. 2013;14(6):601–9.

    Article  PubMed  Google Scholar 

  19. Abend NS, Arndt DH, Carpenter JL, Chapman KE, Cornett KM, Gallentine WB, et al. Electrographic seizures in pediatric ICU patients: cohort study of risk factors and mortality. Neurology. 2013;81(4):383–91.

    Article  PubMed  PubMed Central  Google Scholar 

  20. McCoy B, Sharma R, Ochi A, Go C, Otsubo H, Hutchison JS, et al. Predictors of nonconvulsive seizures among critically ill children. Epilepsia. 2011;52(11):1973–8.

    Article  PubMed  Google Scholar 

  21. Schreiber JM, Zelleke T, Gaillard WD, Kaulas H, Dean N, Carpenter JL. Continuous video EEG for patients with acute encephalopathy in a pediatric intensive care unit. Neurocrit Care. 2012;17(1):31–8.

    Article  PubMed  Google Scholar 

  22. Arndt DH, Lerner JT, Matsumoto JH, Madikians A, Yudovin S, Valino H, et al. Subclinical early posttraumatic seizures detected by continuous EEG monitoring in a consecutive pediatric cohort. Epilepsia. 2013;54(10):1780–8.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Payne ET, Zhao XY, Frndova H, McBain K, Sharma R, Hutchison JS, et al. Seizure burden is independently associated with short term outcome in critically ill children. Brain. 2014;137(Pt 5):1429–38.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Abend NS, Gutierrez-Colina AM, Topjian AA, Zhao H, Guo R, Donnelly M, et al. Nonconvulsive seizures are common in critically ill children. Neurology. 2011;76(12):1071–7.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Gold JJ, Crawford JR, Glaser C, Sheriff H, Wang S, Nespeca M. The role of continuous electroencephalography in childhood encephalitis. Pediatr Neurol. 2014;50(4):318–23.

    Article  PubMed  Google Scholar 

  26. Greiner MV, Greiner HM, Care MM, Owens D, Shapiro R, Holland K. Adding insult to injury: nonconvulsive seizures in abusive head trauma. J Child Neurol. 2015;30(13):1778–84.

    Article  PubMed  Google Scholar 

  27. Gutierrez-Colina AM, Topjian AA, Dlugos DJ, Abend NS. EEG monitoring in critically ill children: indications and strategies. Pediatric Neurology. 2012;46:158–61.

    Article  PubMed  PubMed Central  Google Scholar 

  28. Abend NS, Topjian AA, Williams S. How much does it cost to identify a critically ill child experiencing electrographic seizures? J Clin Neurophysiol. 2015;32:257–64.

    Article  PubMed  PubMed Central  Google Scholar 

  29. Yang A, Arndt DH, Berg RA, Carpenter JL, Chapman KE, Dlugos DJ, et al. Development and validation of a seizure prediction model in critically ill children. Seizure. 2015;25:104–11.

    Article  PubMed  Google Scholar 

  30. Abend NS, Topjian AA, Williams S. How much does it cost to identify a critically ill child experiencing electrographic seizures? J Clin Neurophysiol. 2015;32(3):257–64.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Brophy GM, Bell R, Claassen J, Alldredge B, Bleck TP, Glauser T, et al. Guidelines for the evaluation and management of status epilepticus. Neurocrit Care. 2012;17(1):3–23.

    Article  PubMed  Google Scholar 

  32. Herman ST, Abend NS, Bleck TP, Chapman KE, Drislane FW, Emerson RG, et al. Consensus statement on continuous EEG in critically ill adults and children. Part I: Indications. J Clin Neurophysiol. 2015;32(2):87–95.

    PubMed  Google Scholar 

  33. Abend NS. Electrographic status epilepticus in children with critical illness: epidemiology and outcome. Epilepsy Behav. 2015;49:223–7.

    Article  PubMed  PubMed Central  Google Scholar 

  34. Topjian AA, Gutierrez-Colina AM, Sanchez SM, Berg RA, Friess SH, Dlugos DJ, et al. Electrographic status epilepticus is associated with mortality and worse short-term outcome in critically ill children. Crit Care Med. 2013;31:215–23.

    Article  Google Scholar 

  35. Wagenman KL, Blake TP, Sanchez SM, Schultheis MT, Radcliffe J, Berg RA, et al. Electrographic status epilepticus and long-term outcome in critically ill children. Neurology. 2014;82(5):396–404.

    Article  PubMed  PubMed Central  Google Scholar 

  36. Sanchez SM, Carpenter J, Chapman KE, Dlugos DJ, Gallentine W, Giza CC, et al. Pediatric ICU EEG monitoring: current resources and practice in the united states and canada. J Clin Neurophysiol. 2013;30(2):156–60.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Abend NS, Dlugos DJ, Hahn CD, Hirsch LJ, Herman ST. Use of EEG monitoring and management of non-convulsive seizures in critically ill patients: a survey of neurologists. Neurocrit Care. 2010;12(3):382–9.

    Article  PubMed  PubMed Central  Google Scholar 

  38. Stewart CP, Otsubo H, Ochi A, Sharma R, Hutchison JS, Hahn CD. Seizure identification in the ICU using quantitative EEG displays. Neurology. 2010;75(17):1501–8.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Pensirikul AD, Beslow LA, Kessler SK, Sanchez SM, Topjian AA, Dlugos DJ, et al. Density Spectral Array for Seizure Identification in Critically Ill Children. J Clin Neurophysiol. 2013;30(4):371–5.

    Article  PubMed  PubMed Central  Google Scholar 

  40. Akman CI, Micic V, Thompson A, Riviello Jr JJ. Seizure detection using digital trend analysis: factors affecting utility. Epilepsy Res. 2011;93(1):66–72.

    Article  PubMed  Google Scholar 

  41. Topjian AA, Fry M, Jawad AF, Herman ST, Nadkarni VM, Ichord R, et al. Detection of electrographic seizures by critical care providers using color density spectral array after cardiac arrest is feasible. Pediatr Crit Care Med. 2015;16(5):461–7.

    Article  PubMed  PubMed Central  Google Scholar 

  42. Chin RF, Neville BG, Peckham C, Bedford H, Wade A, Scott RC. Incidence, cause, and short-term outcome of convulsive status epilepticus in childhood: prospective population-based study. Lancet. 2006;368(9531):222–9.

    Article  PubMed  Google Scholar 

  43. Commission on Epidemiology and Prognosis, International League Against Epilepsy. Guidelines for epidemiologic studies on epilepsy. Epilepsia. 1993;34(4):592–6.

    Article  Google Scholar 

  44. Shinnar S, Berg AT, Moshe SL, Shinnar R. How long do new-onset seizures in children last? Ann Neurol. 2001;49(5):659–64.

    Article  CAS  PubMed  Google Scholar 

  45. Lewena S, Pennington V, Acworth J, Thornton S, Ngo P, McIntyre S, et al. Emergency management of pediatric convulsive status epilepticus: a multicenter study of 542 patients. Pediatr Emerg Care. 2009;25(2):83–7.

    Article  PubMed  Google Scholar 

  46. Chin RF, Neville BG, Peckham C, Wade A, Bedford H, Scott RC. Treatment of community-onset, childhood convulsive status epilepticus: a prospective, population-based study. Lancet Neurol. 2008;7(8):696–703.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Lambrechtsen FA, Buchhalter JR. Aborted and refractory status epilepticus in children: a comparative analysis. Epilepsia. 2008;49(4):615–25.

    Article  PubMed  Google Scholar 

  48. Lewena S, Young S. When benzodiazepines fail: how effective is second line therapy for status epilepticus in children? Emerg Med Australas. 2006;18(1):45–50.

    Article  PubMed  Google Scholar 

  49. Eriksson K, Metsaranta P, Huhtala H, Auvinen A, Kuusela AL, Koivikko M. Treatment delay and the risk of prolonged status epilepticus. Neurology. 2005;65(8):1316–8.

    Article  CAS  PubMed  Google Scholar 

  50. Hayashi K, Osawa M, Aihara M, Izumi T, Ohtsuka Y, Haginoya K, et al. Efficacy of intravenous midazolam for status epilepticus in childhood. Pediatr Neurol. 2007;36(6):366–72.

    Article  PubMed  Google Scholar 

  51. Shorvon S, Baulac M, Cross H, Trinka E, Walker M. The drug treatment of status epilepticus in Europe: consensus document from a workshop at the first London colloquium on status epilepticus. Epilepsia. 2008;49(7):1277–86.

    PubMed  Google Scholar 

  52. Taylor C, Piantino J, Hageman J, Lyons E, Janies K, Leonard D, et al. Emergency department management of pediatric unprovoked seizures and status epilepticus in the state of illinois. J Child Neurol. 2015;30(11):1414–27.

    Article  PubMed  Google Scholar 

  53. Abend NS, Loddenkemper T. Pediatric status epilepticus management. Curr Opin Pediatr. 2014;26(6):668–74.

    Article  PubMed  PubMed Central  Google Scholar 

  54. Abend NS, Loddenkemper T. Management of pediatric status epilepticus. Curr Treat Options Neurol. 2014;16(7):301.

    Article  PubMed  PubMed Central  Google Scholar 

  55. Abend NS, Gutierrez-Colina AM, Dlugos DJ. Medical treatment of pediatric status epilepticus. Semin Pediatr Neurol. 2010;17(3):169–75.

    Article  PubMed  Google Scholar 

  56. Abend NS, Bearden D, Helbig I, McGuire J, Narula S, Panzer JA, et al. Status epilepticus and refractory status epilepticus management. Semin Pediatr Neurol. 2014;21(4):263–74.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Wilkes R, Tasker RC. Pediatric intensive care treatment of uncontrolled status epilepticus. Crit Care Clin. 2013;29(2):239–57.

    Article  PubMed  Google Scholar 

  58. Tasker R. Continuous infusions of anticonvulsants and anesthetics used in status epilepticus. Curr Opin Pediatr. 2014;26(6):682–9.

    Article  CAS  PubMed  Google Scholar 

  59. Wilkes R, Tasker RC. Intensive care treatment of uncontrolled status epilepticus in children: systematic literature search of midazolam and anesthetic therapies*. Pediatr Crit Care Med. 2014;15(7):632–9.

    Article  PubMed  Google Scholar 

  60. Shearer P, Riviello J. Generalized convulsive status epilepticus in adults and children: treatment guidelines and protocols. Emerg Med Clin North Am. 2011;29(1):51–64.

    Article  PubMed  Google Scholar 

  61. Hussain N, Appleton R, Thorburn K. Aetiology, course and outcome of children admitted to paediatric intensive care with convulsive status epilepticus: a retrospective 5-year review. Seizure. 2007;16(4):305–12.

    Article  PubMed  Google Scholar 

  62. Singh RK, Stephens S, Berl MM, Chang T, Brown K, Vezina LG, et al. Prospective study of new-onset seizures presenting as status epilepticus in childhood. Neurology. 2010;74(8):636–42.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Nishiyama I, Ohtsuka Y, Tsuda T, Inoue H, Kunitomi T, Shiraga H, et al. An epidemiological study of children with status epilepticus in Okayama, Japan. Epilepsia. 2007;48(6):1133–7.

    Article  PubMed  Google Scholar 

  64. Berg AT, Shinnar S, Levy SR, Testa FM. Status epilepticus in children with newly diagnosed epilepsy. Ann Neurol. 1999;45(5):618–23.

    Article  CAS  PubMed  Google Scholar 

  65. Riviello JJ, Ashwal S, Hirtz D, Glauser T, Ballaban-Gil K, Kelley K, et al. Practice parameter: diagnostic assessment of the child with status epilepticus (an evidence-based review). Neurology. 2006;67:1542–50.

    Article  PubMed  Google Scholar 

  66. Watemberg N, Segal G. A suggested approach to the etiologic evaluation of status epilepticus in children: what to seek after the usual causes have been ruled out. J Child Neurol. 2010;25(2):203–11.

    Article  PubMed  Google Scholar 

  67. Sanchez Fernandez I, Abend NS, Arndt DH, Carpenter JL, Chapman KE, Cornett KM, et al. Electrographic seizures after convulsive status epilepticus in children and young adults. A retrospective multicenter study. J Pediatr. 2014;164(2):339–46.

    Article  PubMed  Google Scholar 

  68. Neligan A, Shorvon SD. Frequency and prognosis of convulsive status epilepticus of different causes: a systematic review. Arch Neurol. 2010;67(8):931–40.

    Article  PubMed  Google Scholar 

  69. Saz EU, Karapinar B, Ozcetin M, Polat M, Tosun A, Serdaroglu G, et al. Convulsive status epilepticus in children: etiology, treatment protocol and outcome. Seizure. 2011;20(2):115–8.

    Article  PubMed  Google Scholar 

  70. Chamberlain JM, Okada P, Holsti M, Mahajan P, Brown KM, Vance C, et al. Lorazepam vs diazepam for pediatric status epilepticus: a randomized clinical trial. JAMA. 2014;311(16):1652–60.

    Article  PubMed  CAS  Google Scholar 

  71. Babl FE, Sheriff N, Borland M, Acworth J, Neutze J, Krieser D, et al. Emergency management of paediatric status epilepticus in Australia and New Zealand: practice patterns in the context of clinical practice guidelines. J Paediatr Child Health. 2009;45(9):541–6.

    Article  PubMed  Google Scholar 

  72. Claassen J, Hirsch LJ, Mayer SA. Treatment of status epilepticus: a survey of neurologists. J Neurol Sci. 2003;211(1–2):37–41.

    Article  PubMed  Google Scholar 

  73. Brevoord JC, Joosten KF, Arts WF, van Rooij RW, de Hoog M. Status epilepticus: clinical analysis of a treatment protocol based on midazolam and phenytoin. J Child Neurol. 2005;20(6):476–81.

    Article  PubMed  Google Scholar 

  74. Sreenath TG, Gupta P, Sharma KK, Krishnamurthy S. Lorazepam versus diazepam-phenytoin combination in the treatment of convulsive status epilepticus in children: a randomized controlled trial. Eur J Paediatr Neurol. 2010;14(2):162–8.

    Article  CAS  PubMed  Google Scholar 

  75. Wolf GK, McClain CD, Zurakowski D, Dodson B, McManus ML. Total phenytoin concentrations do not accurately predict free phenytoin concentrations in critically ill children. Pediatr Crit Care Med. 2006;7(5):434–9. quiz 40

    Article  PubMed  Google Scholar 

  76. Shaner DM, McCurdy SA, Herring MO, Gabor AJ. Treatment of status epileticus: a prospective comparison of diazepam and phenytoin versus phenobarbital and optional phenytoin. Neurology. 1988;38:202–7.

    Article  CAS  PubMed  Google Scholar 

  77. Crawford TO, Mitchell WG, Fishman LS, Snodgrass SR. Very-high-dose phenobarbital for refractory status epilepticus in children. Neurology. 1988;38(7):1035–40.

    Article  CAS  PubMed  Google Scholar 

  78. Wilmshurst JM, van der Walt JS, Ackermann S, Karlsson MO, Blockman M. Rescue therapy with high-dose oral phenobarbitone loading for refractory status epilepticus. J Paediatr Child Health. 2010;46(1–2):17–22.

    Article  PubMed  Google Scholar 

  79. Lin JJ, Lin KL, Wang HS, Hsia SH, Wu CT. Effect of topiramate, in combination with lidocaine, and phenobarbital, in acute encephalitis with refractory repetitive partial seizures. Brain Dev. 2009;31(8):605–11.

    Article  PubMed  Google Scholar 

  80. Yu KT, Mills S, Thompson N, Cunanan C. Safety and efficacy of intravenous valproate in pediatric status epilepticus and acute repetitive seizures. Epilepsia. 2003;44(5):724–6.

    Article  CAS  PubMed  Google Scholar 

  81. Uberall MA, Trollmann R, Wunsiedler U, Wenzel D. Intravenous valproate in pediatric epilepsy patients with refractory status epilepticus. Neurology. 2000;54(11):2188–9.

    Article  CAS  PubMed  Google Scholar 

  82. Mehta V, Singhi P, Singhi S. Intravenous sodium valproate versus diazepam infusion for the control of refractory status epilepticus in children: a randomized controlled trial. J Child Neurol. 2007;22(10):1191–7.

    Article  PubMed  Google Scholar 

  83. Campistol J, Fernandez A, Ortega J. Status epilepticus in children. Experience with intravenous valproate. Update of treatment guidelines. Rev Neurol. 1999;29(4):359–65.

    CAS  PubMed  Google Scholar 

  84. Hovinga CA, Chicella MF, Rose DF, Eades SK, Dalton JT, Phelps SJ. Use of intravenous valproate in three pediatric patients with nonconvulsive or convulsive status epilepticus. Ann Pharmacother. 1999;33(5):579–84.

    Article  CAS  PubMed  Google Scholar 

  85. Abend NS, Chapman KE, Gallentine WB, Goldstein J, Hyslop AE, Loddenkemper T, et al. Electroencephalographic monitoring in the pediatric intensive care unit. Curr Neurol Neurosci Rep. 2013;13(3):330.

    Article  PubMed  PubMed Central  Google Scholar 

  86. Reiter PD, Huff AD, Knupp KG, Valuck RJ. Intravenous levetiracetam in the management of acute seizures in children. Pediatric Neurology. 2010;43(2):117–21.

    Article  PubMed  Google Scholar 

  87. Abend NS, Monk HM, Licht DJ, Dlugos DJ. Intravenous levetiracetam in critically ill children with status epilepticus or acute repetitive seizures. Pediatr Crit Care Med. 2009;10(4):505–10.

    Article  PubMed  PubMed Central  Google Scholar 

  88. Goraya JS, Khurana DS, Valencia I, Melvin JJ, Cruz M, Legido A, et al. Intravenous levetiracetam in children with epilepsy. Pediatr Neurol. 2008;38(3):177–80.

    Article  PubMed  Google Scholar 

  89. Gallentine WB, Hunnicutt AS, Husain AM. Levetiracetam in children with refractory status epilepticus. Epilepsy Behav. 2009;14(1):215–8.

    Article  PubMed  Google Scholar 

  90. McTague A, Kneen R, Kumar R, Spinty S, Appleton R. Intravenous levetiracetam in acute repetitive seizures and status epilepticus in children: experience from a children's hospital. Seizure. 2012;21(7):529–34.

    Article  CAS  PubMed  Google Scholar 

  91. Maytal J, Shinnar S, Moshe SL, Alvarez LA. Low morbidity and mortality of status epilepticus in children. Pediatrics. 1989;83(3):323–31.

    CAS  PubMed  Google Scholar 

  92. Dunn DW. Status epilepticus in children: etiology, clinical features, and outcome. J Child Neurol. 1988;3(3):167–73.

    Article  CAS  PubMed  Google Scholar 

  93. Eriksson KJ, Koivikko MJ. Status epilepticus in children: aetiology, treatment, and outcome. Dev Med Child Neurol. 1997;39(10):652–8.

    Article  CAS  PubMed  Google Scholar 

  94. Holtkamp M, Othman J, Buchheim K, Masuhr F, Schielke E, Meierkord H. A “malignant” variant of status epilepticus. Arch Neurol. 2005;62(9):1428–31.

    Article  PubMed  Google Scholar 

  95. Shorvon S, Ferlisi M. The treatment of super-refractory status epilepticus: a critical review of available therapies and a clinical treatment protocol. Brain. 2011;134(Pt 10):2802–18.

    Article  PubMed  Google Scholar 

  96. Shorvon S. Super-refractory status epilepticus: an approach to therapy in this difficult clinical situation. Epilepsia. 2011;52(Suppl 8):53–6.

    Article  CAS  PubMed  Google Scholar 

  97. Wilder-Smith EP, Lim EC, Teoh HL, Sharma VK, Tan JJ, Chan BP, et al. The NORSE (new-onset refractory status epilepticus) syndrome: defining a disease entity. Ann Acad Med Singapore. 2005;34(7):417–20.

    CAS  PubMed  Google Scholar 

  98. Van Lierde I, Van Paesschen W, Dupont P, Maes A, Sciot R. De novo cryptogenic refractory multifocal febrile status epilepticus in the young adult: a review of six cases. Acta Neurol Belg. 2003;103(2):88–94.

    CAS  PubMed  Google Scholar 

  99. Rathakrishnan R, Wilder-Smith EP. New onset refractory status epilepticus (NORSE). J Neurol Sci. 2009;284(1–2):220. author reply -1

    Article  PubMed  Google Scholar 

  100. Costello DJ, Kilbride RD, Cole AJ. Cryptogenic new onset refractory status epilepticus (NORSE) in adults-Infectious or not? J Neurol Sci. 2009;277(1–2):26–31.

    Article  PubMed  Google Scholar 

  101. Kramer U, Chi CS, Lin KL, Specchio N, Sahin M, Olson H, et al. Febrile infection-related epilepsy syndrome (FIRES): pathogenesis, treatment, and outcome: a multicenter study on 77 children. Epilepsia. 2011;52(11):1956–65.

    Article  PubMed  Google Scholar 

  102. Kramer U, Shorer Z, Ben-Zeev B, Lerman-Sagie T, Goldberg-Stern H, Lahat E. Severe refractory status epilepticus owing to presumed encephalitis. J Child Neurol. 2005;20(3):184–7.

    Article  PubMed  Google Scholar 

  103. van Baalen A, Hausler M, Boor R, Rohr A, Sperner J, Kurlemann G, et al. Febrile infection-related epilepsy syndrome (FIRES): a nonencephalitic encephalopathy in childhood. Epilepsia. 2010;51(7):1323–8.

    Article  PubMed  Google Scholar 

  104. Ismail FY, Kossoff EH. AERRPS, DESC, NORSE, FIRES: multi-labeling or distinct epileptic entities? Epilepsia. 2011;52(11):e185–9.

    Article  PubMed  Google Scholar 

  105. Abend NS, Dlugos DJ. Treatment of refractory status epilepticus: literature review and a proposed protocol. Pediatr Neurol. 2008;38(6):377–90.

    Article  PubMed  Google Scholar 

  106. Owens J. Medical management of refractory status epilepticus. Semin Pediatr Neurol. 2010;17(3):176–81.

    Article  PubMed  Google Scholar 

  107. Wheless JW. Treatment of refractory convulsive status epilepticus in children: other therapies. Semin Pediatr Neurol. 2010;17(3):190–4.

    Article  PubMed  Google Scholar 

  108. Riviello Jr JJ, Claassen J, LaRoche SM, Sperling MR, Alldredge B, Bleck TP, et al. Treatment of status epilepticus: an international survey of experts. Neurocrit Care. 2013;18(2):193–200.

    Article  PubMed  Google Scholar 

  109. Kim SJ, Lee DY, Kim JS. Neurologic outcomes of pediatric epileptic patients with pentobarbital coma. Pediatr Neurol. 2001;25(3):217–20.

    Article  CAS  PubMed  Google Scholar 

  110. Morrison G, Gibbons E, Whitehouse WP. High-dose midazolam therapy for refractory status epilepticus in children. Intensive Care Med. 2006;32(12):2070–6.

    Article  CAS  PubMed  Google Scholar 

  111. Singhi S, Murthy A, Singhi P, Jayashree M. Continuous midazolam versus diazepam infusion for refractory convulsive status epilepticus. J Child Neurol. 2002;17(2):106–10.

    Article  PubMed  Google Scholar 

  112. Koul R, Chacko A, Javed H, Al Riyami K. Eight-year study of childhood status epilepticus: midazolam infusion in management and outcome. J Child Neurol. 2002;17(12):908–10.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Nicholas S. Abend .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Abend, N.S. (2017). Seizures and Status Epilepticus in Pediatric Critical Care. In: Varelas, P., Claassen, J. (eds) Seizures in Critical Care. Current Clinical Neurology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-49557-6_22

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-49557-6_22

  • Published:

  • Publisher Name: Humana Press, Cham

  • Print ISBN: 978-3-319-49555-2

  • Online ISBN: 978-3-319-49557-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics