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Local Infiltration Analgesia for Orthopedic Joint Surgery

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References

  1. Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am. 2007;89:780–5.

    PubMed  Google Scholar 

  2. Beaussier M, Sciard D, Sautet A. New modalities of pain treatment after outpatient orthopaedic surgery. Orthop Traumatol Surg Res. 2016;102:S121–4.

    Article  CAS  PubMed  Google Scholar 

  3. Cozowicz C, Poeran J, Memtsoudis SG. Epidemiology, trends, and disparities in regional anaesthesia for orthopaedic surgery. Br J Anaesth. 2015;115(Suppl 2):ii57–67.

    Article  PubMed  Google Scholar 

  4. Fredrickson MJ, Krishnan S, Chen CY. Postoperative analgesia for shoulder surgery: a critical appraisal and review of current techniques. Anaesthesia. 2010;65:608–24.

    Article  CAS  PubMed  Google Scholar 

  5. Ilfeld BM, Meunier MJ, Macario A. Ambulatory continuous peripheral nerve blocks and the perioperative surgical home. Anesthesiology. 2015;123:1224–6.

    Article  PubMed  Google Scholar 

  6. Affas F, Nygards EB, Stiller CO, Wretenberg P, Olofsson C. Pain control after total knee arthroplasty: a randomized trial comparing local infiltration anesthesia and continuous femoral block. Acta Orthop. 2011;82:441–7.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Andersen KV, Bak M, Christensen BV, Harazuk J, Pedersen NA, Soballe K. A randomized, controlled trial comparing local infiltration analgesia with epidural infusion for total knee arthroplasty. Acta Orthop. 2010;81:606–10.

    Article  PubMed  PubMed Central  Google Scholar 

  8. Andersen LO, Husted H, Otte KS, Kristensen BB, Kehlet H. High-volume infiltration analgesia in total knee arthroplasty: a randomized, double-blind, placebo-controlled trial. Acta Anaesthesiol Scand. 2008;52:1331–5.

    Article  CAS  PubMed  Google Scholar 

  9. Andersen LO, Husted H, Kristensen BB, Otte KS, Gaarn-Larsen L, Kehlet H. Analgesic efficacy of subcutaneous local anaesthetic wound infiltration in bilateral knee arthroplasty: a randomised, placebo-controlled, double-blind trial. Acta Anaesthesiol Scand. 2010;54:543–8.

    Article  CAS  PubMed  Google Scholar 

  10. Carli F, Clemente A, Asenjo JF, Kim DJ, Mistraletti G, Gomarasca M, Morabito A, Tanzer M. Analgesia and functional outcome after total knee arthroplasty: periarticular infiltration vs continuous femoral nerve block. Br J Anaesth. 2010;105:185–95.

    Article  CAS  PubMed  Google Scholar 

  11. Essving P, Axelsson K, Kjellberg J, Wallgren O, Gupta A, Lundin A. Reduced morphine consumption and pain intensity with local infiltration analgesia (LIA) following total knee arthroplasty. Acta Orthop. 2010;81:354–60.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Essving P, Axelsson K, Aberg E, Spannar H, Gupta A, Lundin A. Local infiltration analgesia versus intrathecal morphine for postoperative pain management after total knee arthroplasty: a randomized controlled trial. Anesth Analg. 2011;113:926–33.

    Article  CAS  PubMed  Google Scholar 

  13. Fan L, Yu X, Zan P, Liu J, Ji T, Li G. Comparison of local infiltration analgesia with femoral nerve block for total knee arthroplasty: a prospective randomized clinical trial. J Arthroplasty. 2016;31:1361–5.

    Article  PubMed  Google Scholar 

  14. Ganapathy S, Brookes J, Bourne R. Local infiltration analgesia. Anesthesiol Clin. 2011;29:329–42.

    Article  PubMed  Google Scholar 

  15. Kehlet H, Andersen LO. Local infiltration analgesia in joint replacement: the evidence and recommendations for clinical practice. Acta Anaesthesiol Scand. 2011;55:778–84.

    Article  PubMed  Google Scholar 

  16. Kerr DR, Kohan L. Local infiltration analgesia: a technique for the control of acute postoperative pain following knee and hip surgery: a case study of 325 patients. Acta Orthop. 2008;79:174–83.

    Article  PubMed  Google Scholar 

  17. McCartney CJ, McLeod GA. Local infiltration analgesia for total knee arthroplasty. Br J Anaesth. 2011;107:487–9.

    Article  CAS  PubMed  Google Scholar 

  18. Ong JC, Chin PL, Fook-Chong SM, Tang A, Yang KY, Tay BK. Continuous infiltration of local anaesthetic following total knee arthroplasty. J Orthop Surg (Hong Kong). 2010;18:203–7.

    Article  Google Scholar 

  19. Rostlund T, Kehlet H. High-dose local infiltration analgesia after hip and knee replacement--what is it, why does it work, and what are the future challenges? Acta Orthop. 2007;78:159–61.

    Article  PubMed  Google Scholar 

  20. Toftdahl K, Nikolajsen L, Haraldsted V, Madsen F, Tonnesen EK, Soballe K. Comparison of peri- and intraarticular analgesia with femoral nerve block after total knee arthroplasty: a randomized clinical trial. Acta Orthop. 2007;78:172–9.

    Article  PubMed  Google Scholar 

  21. Tripuraneni KR, Woolson ST, Giori NJ. Local infiltration analgesia in TKA patients reduces length of stay and postoperative pain scores. Orthopedics. 2011;34:173.

    Article  PubMed  Google Scholar 

  22. Vaishya R, Wani AM, Vijay V. Local infiltration analgesia reduces pain and hospital stay after primary TKA: randomized controlled double blind trial. Acta Orthop Belg. 2015;81:720–9.

    PubMed  Google Scholar 

  23. Maheshwari AV, Blum YC, Shekhar L, Ranawat AS, Ranawat CS. Multimodal pain management after total hip and knee arthroplasty at the Ranawat Orthopaedic Center. Clin Orthop Relat Res. 2009;467:1418–23.

    Article  PubMed  PubMed Central  Google Scholar 

  24. Gehling M, Tryba M. Risks and side-effects of intrathecal morphine combined with spinal anaesthesia: a meta-analysis. Anaesthesia. 2009;64:643–51.

    Article  CAS  PubMed  Google Scholar 

  25. Scott NB. Wound infiltration for surgery. Anaesthesia. 2010;65(Suppl 1):67–75.

    Article  PubMed  Google Scholar 

  26. Markel H. Uber coca: Sigmund Freud, Carl Koller, and cocaine. JAMA. 2011;305:1360–1.

    Article  CAS  PubMed  Google Scholar 

  27. Lopez-Valverde A, de Vicente J, Cutando A. The surgeons Halsted and Hall, cocaine and the discovery of dental anaesthesia by nerve blocking. Br Dent J. 2011;211:485–7.

    Article  CAS  PubMed  Google Scholar 

  28. Goerig M. Carl Ludwig Schleich and the introduction of infiltration anesthesia into clinical practice. Reg Anesth Pain Med. 1998;23:538–9.

    Article  CAS  PubMed  Google Scholar 

  29. Wawersik J. History of anesthesia in Germany. J Clin Anesth. 1991;3:235–44.

    Article  CAS  PubMed  Google Scholar 

  30. Fredman B, Shapiro A, Zohar E, Feldman E, Shorer S, Rawal N, Jedeikin R. The analgesic efficacy of patient-controlled ropivacaine instillation after Cesarean delivery. Anesth Analg. 2000;91:1436–40.

    Article  CAS  PubMed  Google Scholar 

  31. Hannibal K, Galatius H, Hansen A, Obel E, Ejlersen E. Preoperative wound infiltration with bupivacaine reduces early and late opioid requirement after hysterectomy. Anesth. Analg. 1996;83:376–81.

    Article  CAS  PubMed  Google Scholar 

  32. Horn EP, Schroeder F, Wilhelm S, Wappler F, Sessler DI, Uebe B, Standl T. Schulte am EJ: wound infiltration and drain lavage with ropivacaine after major shoulder surgery. Anesth Analg. 1999;89:1461–6.

    CAS  PubMed  Google Scholar 

  33. Oakley MJ, Smith JS, Anderson JR, Fenton-Lee D. Randomized placebo-controlled trial of local anaesthetic infusion in day-case inguinal hernia repair. Br J Surg. 1998;85:797–9.

    Article  CAS  PubMed  Google Scholar 

  34. Partridge BL, Stabile BE. The effects of incisional bupivacaine on postoperative narcotic requirements, oxygen saturation and length of stay in the post-anesthesia care unit. Acta Anaesthesiol Scand. 1990;34:486–91.

    Article  CAS  PubMed  Google Scholar 

  35. Pettersson N, Emanuelsson BM, Reventlid H, Hahn RG. High-dose ropivacaine wound infiltration for pain relief after inguinal hernia repair: a clinical and pharmacokinetic evaluation. Reg Anesth Pain Med. 1998;23:189–96.

    Article  CAS  PubMed  Google Scholar 

  36. Rawal N, Axelsson K, Hylander J, Allvin R, Amilon A, Lidegran G, Hallen J. Postoperative patient-controlled local anesthetic administration at home. Anesth. Analg. 1998;86:86–9.

    CAS  PubMed  Google Scholar 

  37. Bianconi M, Ferraro L, Traina GC, Zanoli G, Antonelli T, Guberti A, Ricci R, Massari L. Pharmacokinetics and efficacy of ropivacaine continuous wound instillation after joint replacement surgery. Br J Anaesth. 2003;91:830–5.

    Article  CAS  PubMed  Google Scholar 

  38. Busch CA, Whitehouse MR, Shore BJ, MacDonald SJ, McCalden RW, Bourne RB. The efficacy of periarticular multimodal drug infiltration in total hip arthroplasty. Clin Orthop Relat Res. 2010;468:2152–9.

    Article  PubMed  Google Scholar 

  39. Vendittoli PA, Makinen P, Drolet P, Lavigne M, Fallaha M, Guertin MC, Varin F. A multimodal analgesia protocol for total knee arthroplasty. a randomized, controlled study. J Bone Joint Surg Am. 2006;88:282–9.

    Article  PubMed  Google Scholar 

  40. Jiang J, Teng Y, Fan Z, Khan MS, Cui Z, Xia Y. The efficacy of periarticular multimodal drug injection for postoperative pain management in total knee or hip arthroplasty. J Arthroplasty. 2013;28:1882–7.

    Article  PubMed  Google Scholar 

  41. Kelley TC, Adams MJ, Mulliken BD, Dalury DF. Efficacy of multimodal perioperative analgesia protocol with periarticular medication injection in total knee arthroplasty: a randomized, double-blinded study. J Arthroplasty. 2013;28:1274–7.

    Article  PubMed  Google Scholar 

  42. Parvataneni HK, Shah VP, Howard H, Cole N, Ranawat AS, Ranawat CS. Controlling pain after total hip and knee arthroplasty using a multimodal protocol with local periarticular injections: a prospective randomized study. J Arthroplasty. 2007;22:33–8.

    Article  PubMed  Google Scholar 

  43. Spangehl MJ, Clarke HD, Hentz JG, Misra L, Blocher JL, Seamans DP. The Chitranjan Ranawat Award: periarticular injections and femoral & sciatic blocks provide similar pain relief after TKA: a randomized clinical trial. Clin Orthop Relat Res. 2015;473:45–53.

    Article  PubMed  Google Scholar 

  44. Bramlett K, Onel E, Viscusi ER, Jones K. A randomized, double-blind, dose-ranging study comparing wound infiltration of DepoFoam bupivacaine, an extended-release liposomal bupivacaine, to bupivacaine HCl for postsurgical analgesia in total knee arthroplasty. Knee. 2012;19:530–6.

    Article  PubMed  Google Scholar 

  45. Bagsby DT, Ireland PH, Meneghini RM. Liposomal bupivacaine versus traditional periarticular injection for pain control after total knee arthroplasty. J Arthroplasty. 2014;29:1687–90.

    Article  PubMed  Google Scholar 

  46. Collis PN, Hunter AM, Vaughn MD, Carreon LY, Huang J, Malkani AL. Periarticular injection after total knee arthroplasty using liposomal bupivacaine vs a modified ranawat suspension: a prospective randomized study. J Arthroplasty. 2016;31:633–6.

    Article  PubMed  Google Scholar 

  47. Schroer WC, Diesfeld PG, LeMarr AR, Morton DJ, Reedy ME. Does extended-release liposomal bupivacaine better control pain than bupivacaine after total knee arthroplasty (TKA)? A prospective randomized clinical trial. J Arthroplasty. 2015;30:64–7.

    Article  PubMed  Google Scholar 

  48. Lambrechts M, O’Brien MJ, Savoie FH, You Z. Liposomal extended-release bupivacaine for postsurgical analgesia. Patient Prefer Adherence. 2013;7:885–90.

    PubMed  PubMed Central  Google Scholar 

  49. Memtsoudis SG, Danninger T, Rasul R, Poeran J, Gerner P, Stundner O, Mariano ER, Mazumdar M. Inpatient falls after total knee arthroplasty: the role of anesthesia type and peripheral nerve blocks. Anesthesiology. 2014;120:551–63.

    Article  PubMed  Google Scholar 

  50. Pelt CE, Anderson AW, Anderson MB, Van DC, Peters CL. Postoperative falls after total knee arthroplasty in patients with a femoral nerve catheter: can we reduce the incidence? J. Arthroplasty. 2014;29:1154–7.

    Article  Google Scholar 

  51. Hebert-Blouin MN, Tubbs RS, Carmichael SW, Spinner RJ. Hilton’s law revisited. Clin Anat. 2014;27:548–55.

    Article  PubMed  Google Scholar 

  52. Alzaharani A, Bali K, Gudena R, Railton P, Ponjevic D, Matyas JR, Powell JN. The innervation of the human acetabular labrum and hip joint: an anatomic study. BMC Musculoskelet Disord. 2014;15:41.

    Article  PubMed  PubMed Central  Google Scholar 

  53. Guild III GN, Galindo RP, Marino J, Cushner FD, Scuderi GR. Periarticular regional analgesia in total knee arthroplasty: a review of the neuroanatomy and injection technique. Orthop Clin North Am. 2015;46:1–8.

    Article  PubMed  Google Scholar 

  54. Stein C, Kuchler S. Non-analgesic effects of opioids: peripheral opioid effects on inflammation and wound healing. Curr Pharm Des. 2012;18:6053–69.

    Article  CAS  PubMed  Google Scholar 

  55. Spreng UJ, Dahl V, Hjall A, Fagerland MW, Raeder J. High-volume local infiltration analgesia combined with intravenous or local ketorolac+morphine compared with epidural analgesia after total knee arthroplasty. Br J Anaesth. 2010;105:675–82.

    Article  CAS  PubMed  Google Scholar 

  56. Simons MJ, Amin NH, Cushner FD, Scuderi GR. Characterization of the neural anatomy in the hip joint to optimize periarticular regional anesthesia in total hip arthroplasty. J Surg Orthop Adv. 2015;24:221–4.

    Article  PubMed  Google Scholar 

  57. Dillon JP, Brennan L, Mitchell D. Local infiltration analgesia in hip and knee arthroplasty: an emerging technique. Acta Orthop Belg. 2012;78:158–63.

    PubMed  Google Scholar 

  58. Greze J, Vighetti A, Incagnoli P, Quesada JL, Albaladejo P, Palombi O, Tonetti J, Bosson JL, Payen JF. Does continuous wound infiltration enhance baseline intravenous multimodal analgesia after posterior spinal fusion surgery? A randomized, double-blinded, placebo-controlled study. Eur Spine J. 2016 Feb 10. [Epub ahead of print]

    Google Scholar 

  59. Butterfield NN, Schwarz SK, Ries CR, Franciosi LG, Day B, MacLeod BA. Combined pre- and post-surgical bupivacaine wound infiltrations decrease opioid requirements after knee ligament reconstruction. Can J Anaesth. 2001;48:245–50.

    Article  CAS  PubMed  Google Scholar 

  60. Hoenecke Jr HR, Pulido PA, Morris BA, Fronek J. The efficacy of continuous bupivacaine infiltration following anterior cruciate ligament reconstruction. Arthroscopy. 2002;18:854–8.

    Article  PubMed  Google Scholar 

  61. Hoher J, Kersten D, Bouillon B, Neugebauer E, Tiling T. Local and intra-articular infiltration of bupivacaine before surgery: effect on postoperative pain after anterior cruciate ligament reconstruction. Arthroscopy. 1997;13:210–7.

    Article  CAS  PubMed  Google Scholar 

  62. Koh IJ, Chang CB, Seo ES, Kim SJ, Seong SC, Kim TK. Pain management by periarticular multimodal drug injection after anterior cruciate ligament reconstruction: a randomized, controlled study. Arthroscopy. 2012;28:649–57.

    Article  PubMed  Google Scholar 

  63. Kristensen PK, Pfeiffer-Jensen M, Storm JO, Thillemann TM. Local infiltration analgesia is comparable to femoral nerve block after anterior cruciate ligament reconstruction with hamstring tendon graft: a randomised controlled trial. Knee Surg Sports Traumatol Arthrosc. 2014;22:317–23.

    Article  PubMed  Google Scholar 

  64. Baker JF, McGuire CM, Byrne DP, Hunter K, Eustace N, Mulhall KJ. Analgesic control after hip arthroscopy: a randomised, double-blinded trial comparing portal with intra-articular infiltration of bupivacaine. Hip Int. 2011;21:373–7.

    Article  PubMed  Google Scholar 

  65. Essving P, Axelsson K, Kjellberg J, Wallgren O, Gupta A, Lundin A. Reduced hospital stay, morphine consumption, and pain intensity with local infiltration analgesia after unicompartmental knee arthroplasty. Acta Orthop. 2009;80:213–9.

    Article  PubMed  PubMed Central  Google Scholar 

  66. Essving P, Axelsson K, Otterborg L, Spannar H, Gupta A, Magnuson A, Lundin A. Minimally invasive surgery did not improve outcome compared to conventional surgery following unicompartmental knee arthroplasty using local infiltration analgesia: a randomized controlled trial with 40 patients. Acta Orthop. 2012;83:634–41.

    Article  PubMed  PubMed Central  Google Scholar 

  67. Andersen LO, Kehlet H. Analgesic efficacy of local infiltration analgesia in hip and knee arthroplasty: a systematic review. Br J Anaesth. 2014;113:360–74.

    Article  CAS  PubMed  Google Scholar 

  68. Jimenez-Almonte JH, Wyles CC, Wyles SP, Norambuena-Morales GA, Baez PJ, Murad MH, Sierra RJ. Is local infiltration analgesia superior to peripheral nerve blockade for pain management after THA: a network meta-analysis. Clin Orthop Relat Res. 2016;474:495–516.

    Article  PubMed  Google Scholar 

  69. Yan H, Cang J, Xue Z, Lu J, Wang H. Comparison of local infiltration and epidural analgesia for postoperative pain control in total knee arthroplasty and total hip arthroplasty: a systematic review and meta-analysis. Bosn J Basic Med Sci. 2016; doi:10.17305/bjbms.2016.1072.

    Google Scholar 

  70. Xu CP, Li X, Wang ZZ, Song JQ, Yu B. Efficacy and safety of single-dose local infiltration of analgesia in total knee arthroplasty: a meta-analysis of randomized controlled trials. Knee. 2014;21:636–46.

    Article  PubMed  Google Scholar 

  71. Sun XL, Zhao ZH, Ma JX, Li FB, Li YJ, Meng XM, Ma XL. Continuous local infiltration analgesia for pain control after total knee arthroplasty: a meta-analysis of randomized controlled trials. Medicine (Baltimore). 2015;94:e2005.

    Article  CAS  Google Scholar 

  72. Hu B, Lin T, Yan SG, Tong SL, Yu JH, Xu JJ, Ying YM. Local infiltration analgesia versus regional blockade for postoperative analgesia in total knee arthroplasty: a meta-analysis of randomized controlled trials. Pain Physician. 2016;19:205–14.

    PubMed  Google Scholar 

  73. Albrecht E, Guyen O, Jacot-Guillarmod A, Kirkham KR. The analgesic efficacy of local infiltration analgesia vs femoral nerve block after total knee arthroplasty: a systematic review and meta-analysis. Br J Anaesth. 2016;116:597–609.

    Article  CAS  PubMed  Google Scholar 

  74. Mei S, Jin S, Chen Z, Ding X, Zhao X, Li Q. Analgesia for total knee arthroplasty: a meta-analysis comparing local infiltration and femoral nerve block. Clinics (Sao Paulo). 2015;70:648–53.

    Article  Google Scholar 

  75. Fan L, Zhu C, Zan P, Yu X, Liu J, Sun Q, Li G. The comparison of local infiltration analgesia with peripheral nerve block following total knee arthroplasty (TKA): a systematic review with meta-analysis. J.Arthroplasty. 2015;30:1664–71.

    Article  PubMed  Google Scholar 

  76. Dobrydnjov I, Anderberg C, Olsson C, Shapurova O, Angel K, Bergman S. Intraarticular vs. extraarticular ropivacaine infusion following high-dose local infiltration analgesia after total knee arthroplasty: a randomized double-blind study. Acta Orthop. 2011;82:692–8.

    Article  PubMed  PubMed Central  Google Scholar 

  77. Anderson SL, Buchko JZ, Taillon MR, Ernst MA. Chondrolysis of the glenohumeral joint after infusion of bupivacaine through an intra-articular pain pump catheter: a report of 18 cases. Arthroscopy. 2010;26:451–61.

    Article  PubMed  Google Scholar 

  78. Matsen III FA, Papadonikolakis A. Published evidence demonstrating the causation of glenohumeral chondrolysis by postoperative infusion of local anesthetic via a pain pump. J Bone Joint Surg Am. 2013;95:1126–34.

    Article  PubMed  Google Scholar 

  79. Rao AJ, Johnston TR, Harris AH, Smith RL, Costouros JG. Inhibition of chondrocyte and synovial cell death after exposure to commonly used anesthetics: chondrocyte apoptosis after anesthetics. Am J Sports Med. 2014;42:50–8.

    Article  PubMed  Google Scholar 

  80. Rapley JH, Beavis RC, Barber FA. Glenohumeral chondrolysis after shoulder arthroscopy associated with continuous bupivacaine infusion. Arthroscopy. 2009;25:1367–73.

    Article  PubMed  Google Scholar 

  81. Serrato Jr JA, Fleckenstein CM, Hasan SS. Glenohumeral chondrolysis associated with use of an intra-articular pain pump delivering local anesthetics following manipulation under anesthesia: a report of four cases. J Bone Joint Surg Am. 2011;93:e99–8.

    Article  PubMed  Google Scholar 

  82. Solomon DJ, Navaie M, Stedje-Larsen ET, Smith JC, Provencher MT. Glenohumeral chondrolysis after arthroscopy: a systematic review of potential contributors and causal pathways. Arthroscopy. 2009;25:1329–42.

    Article  PubMed  Google Scholar 

  83. Wiater BP, Neradilek MB, Polissar NL, Matsen III FA. Risk factors for chondrolysis of the glenohumeral joint: a study of three hundred and seventy-five shoulder arthroscopic procedures in the practice of an individual community surgeon. J Bone Joint Surg Am. 2011;93:615–25.

    Article  PubMed  Google Scholar 

  84. Lo IK, Sciore P, Chung M, Liang S, Boorman RB, Thornton GM, Rattner JB, Muldrew K. Local anesthetics induce chondrocyte death in bovine articular cartilage disks in a dose- and duration-dependent manner. Arthroscopy. 2009;25:707–15.

    Article  PubMed  Google Scholar 

  85. Chu CR, Izzo NJ, Papas NE, Fu FH. In vitro exposure to 0.5 % bupivacaine is cytotoxic to bovine articular chondrocytes. Arthroscopy. 2006;22:693–9.

    Article  PubMed  Google Scholar 

  86. Gomoll AH, Kang RW, Williams JM, Bach BR, Cole BJ. Chondrolysis after continuous intra-articular bupivacaine infusion: an experimental model investigating chondrotoxicity in the rabbit shoulder. Arthroscopy. 2006;22:813–9.

    Article  PubMed  Google Scholar 

  87. Karpie JC, Chu CR. Lidocaine exhibits dose- and time-dependent cytotoxic effects on bovine articular chondrocytes in vitro. Am J Sports Med. 2007;35:1621–7.

    Article  PubMed  Google Scholar 

  88. Piper SL, Kim HT. Comparison of ropivacaine and bupivacaine toxicity in human articular chondrocytes. J Bone Joint Surg Am. 2008;90:986–91.

    Article  PubMed  Google Scholar 

  89. Hashimoto K, Hampl KF, Nakamura Y, Bollen AW, Feiner J, Drasner K. Epinephrine increases the neurotoxic potential of intrathecally administered lidocaine in the rat. Anesthesiology. 2001;94:876–81.

    Article  CAS  PubMed  Google Scholar 

  90. Wang YL, Zeng C, Xie DX, Yang Y, Wei J, Yang T, Li H, Lei GH. Single-dose intra-articular bupivacaine plus morphine after knee arthroscopic surgery: a meta-analysis of randomised placebo-controlled studies. BMJ Open. 2015;5:e006815.

    Article  PubMed  PubMed Central  Google Scholar 

  91. Bjornholdt KT, Jensen JM, Bendtsen TF, Soballe K, Nikolajsen L. Local infiltration analgesia versus continuous interscalene brachial plexus block for shoulder replacement pain: a randomized clinical trial. Eur J Orthop Surg Traumatol. 2015;25:1245–52.

    Article  PubMed  Google Scholar 

  92. Ali A, Sundberg M, Hansson U, Malmvik J, Flivik G. Doubtful effect of continuous intraarticular analgesia after total knee arthroplasty: a randomized double-blind study of 200 patients. Acta Orthop. 2015;86:373–7.

    Article  PubMed  PubMed Central  Google Scholar 

  93. Amlie E, Lerdal A, Gay CL, Hovik O, Nordsletten L, Dimmen S. A trend for increased risk of revision surgery due to deep infection following fast-track hip arthroplasty. Adv Orthop. 2016;2016:7901953.

    Article  PubMed  PubMed Central  Google Scholar 

  94. Capdevila X, Bringuier S, Borgeat A. Infectious risk of continuous peripheral nerve blocks. Anesthesiology. 2009;110:182–8.

    Article  PubMed  Google Scholar 

  95. Cuvillon P, Ripart J, Lalourcey L, Veyrat E, L’Hermite J, Boisson C, Thouabtia E, Eledjam JJ. The continuous femoral nerve block catheter for postoperative analgesia: bacterial colonization, infectious rate and adverse effects. Anesth Analg. 2001;93:1045–9.

    Article  CAS  PubMed  Google Scholar 

  96. Neuburger M, Breitbarth J, Reisig F, Lang D, Buttner J. Complications and adverse events in continuous peripheral regional anesthesia results of investigations on 3,491 catheters. Anaesthesist. 2006;55:33–40.

    Article  CAS  PubMed  Google Scholar 

  97. Kinghorn K, Ellinas H, Barboi AC, Dolinski SY. Case scenario: nerve injury after knee arthroplasty and sciatic nerve block. Anesthesiology. 2012;116:918–23.

    Article  PubMed  Google Scholar 

  98. Maruyama M. Long-tapered double needle used to reduce needle stick nerve injury. Reg Anesth. 1997;22:157–60.

    Article  CAS  PubMed  Google Scholar 

  99. Selander D, Dhuner KG, Lundborg G. Peripheral nerve injury due to injection needles used for regional anesthesia. An experimental study of the acute effects of needle point trauma. Acta Anaesthesiol Scand. 1977;21:182–8.

    Article  CAS  PubMed  Google Scholar 

  100. Steinfeldt T, Nimphius W, Werner T, Vassiliou T, Kill C, Karakas E, Wulf H, Graf J. Nerve injury by needle nerve perforation in regional anaesthesia: does size matter? Br J Anaesth. 2010;104:245–53.

    Article  CAS  PubMed  Google Scholar 

  101. Steinfeldt T, Werner T, Nimphius W, Wiesmann T, Kill C, Muller HH, Wulf H, Graf J. Histological analysis after peripheral nerve puncture with pencil-point or Tuohy needletip. Anesth. Analg. 2011;112:465–70.

    Article  PubMed  Google Scholar 

  102. Tucker GT. Pharmacokinetics of local anaesthetics. Br J Anaesth. 1986;58:717–31.

    Article  CAS  PubMed  Google Scholar 

  103. Brydone AS, Souvatzoglou R, Abbas M, Watson DG, McDonald DA, Gill AM. Ropivacaine plasma levels following high-dose local infiltration analgesia for total knee arthroplasty. Anaesthesia. 2015;70:784–90.

    Article  CAS  PubMed  Google Scholar 

  104. Knudsen K, Beckman SM, Blomberg S, Sjovall J, Edvardsson N. Central nervous and cardiovascular effects of i.v. infusions of ropivacaine, bupivacaine and placebo in volunteers. Br J Anaesthesia. 1997;78:507–14.

    Article  CAS  Google Scholar 

  105. Gill AM, Scott NB, Abbas M, Watson DG, Place K, McDonald DA. Ropivacaine plasma levels following local infiltration analgesia for primary total hip arthroplasty. Anaesthesia. 2014;69:368–73.

    Article  CAS  PubMed  Google Scholar 

  106. Affas F, Eksborg S, Wretenberg P, Olofsson C, Stiller CO. Ropivacaine pharmacokinetics after local infiltration analgesia in hip arthroplasty. Anesth. Analg. 2014;119:996–9.

    Article  CAS  PubMed  Google Scholar 

  107. Kumar SK, Rao V, Morris RG, Watts RW, Westley IS. Ropivacaine (total and unbound) and AGP concentrations after transversus abdominis plane block for analgesia after abdominal surgery. Ther Drug Monit. 2014;36:759–64.

    Article  CAS  PubMed  Google Scholar 

  108. Abrao J, Fernandes CR, White PF, Shimano AC, Okubo R, Lima GB, Bachur JA, Garcia SB. Effect of local anaesthetic infiltration with bupivacaine and ropivacaine on wound healing: a placebo-controlled study. Int Wound J. 2014;11:379–85.

    Article  PubMed  Google Scholar 

  109. Andersen KV, Nikolajsen L, Haraldsted V, Odgaard A, Soballe K. Local infiltration analgesia for total knee arthroplasty: should ketorolac be added? Br J Anaesth. 2013;111:242–8.

    Article  CAS  PubMed  Google Scholar 

  110. Glassman SD, Rose SM, Dimar JR, Puno RM, Campbell MJ, Johnson JR. The effect of postoperative nonsteroidal anti-inflammatory drug administration on spinal fusion. Spine (Phila Pa 1976.). 1998;23:834–8.

    Article  CAS  Google Scholar 

  111. Persson PE, Sodemann B, Nilsson OS. Preventive effects of ibuprofen on periarticular heterotopic ossification after total hip arthroplasty. A randomized double-blind prospective study of treatment time. Acta Orthop Scand. 1998;69:111–5.

    Article  CAS  PubMed  Google Scholar 

  112. Nizam I, Kohan L, Field C, Kerr D. Do nonsteroidal anti-inflammatory drugs cause endoprosthetic loosening? Mid- to long-term follow-up of 100 total hip arthroplasties after local NSAID infiltration. Biomed Res Int. 2015;2015:703071.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  113. Baxter R, Bramlett K, Onel E, Daniels S. Impact of local administration of liposome bupivacaine for postsurgical analgesia on wound healing: a review of data from ten prospective, controlled clinical studies. Clin Ther. 2013;35:312–20.

    Article  CAS  PubMed  Google Scholar 

  114. Uskova A, O’Connor JE. Liposomal bupivacaine for regional anesthesia. Curr Opin Anaesthesiol. 2015;28:593–7.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Rakesh V. Sondekoppam MBBS, MD .

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Ganapathy, S., Howard, J.L., Sondekoppam, R.V. (2017). Local Infiltration Analgesia for Orthopedic Joint Surgery. In: Finucane, B., Tsui, B. (eds) Complications of Regional Anesthesia. Springer, Cham. https://doi.org/10.1007/978-3-319-49386-2_24

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