Skip to main content

Reactive Pathology of the Epididymis

  • Chapter
  • First Online:
  • 1313 Accesses

Abstract

The epididymis is susceptible to being injured secondary to situations that cause an obstruction of the spermatic ducts when the absorption capacity of testicular fluid and duct dilation are exceeded. Sonographically the expansion of the duct can simulate the “filarial dance” described in epididymides of adult men infected with Wuchereria bancrofti. The wall rupture leads to extravasations of spermatozoa and development of spermatic granulomas or an isthmic nodosa epididymitis, completely similar to the vasitis with the same name. Even in the best situation, a prolonged obstruction causes histological changes in the epididymis wall, altering the motility that can lead to situations of unbearable pain requiring surgical intervention. Increased phagocytosis of cells of the efferent ductules elicits changes called Paneth cell-like changes. Ischemia of the epididymis can cause a reaction (ischemic epididymitis) simulating bacterial granulomatous lesions. The prostate and squamous metaplasia are also included in this chapter.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Pelliccione F, Cordeschi G, Giuliani V, D’Abrizio P, Necozione S, Negri L, Mancini M, Sagone P, Francavilla F, Colpi GM, Francavilla S. The contractile wall of the caput epididymidis in men affected by congenital or postinflammatory obstructive azoospermia. J Androl. 2004;25:417–25.

    Article  PubMed  Google Scholar 

  2. McDonald SW. Vasectomy review: sequelae in the human epididymis and ductus deferens. Clin Anat. 1996;9:337–42.

    Article  CAS  PubMed  Google Scholar 

  3. Woodward PJ, Schwab CM, Sesterhenn IA. From the archives of the AFIP: extratesticular scrotal masses: radiologic-pathologic correlation. Radiographics. 2003;23:215–40.

    Article  PubMed  Google Scholar 

  4. Christiansen CG, Sandlow JI. Testicular pain following vasectomy: a review of postvasectomy pain syndrome. J Androl. 2003;24:293–8.

    Article  PubMed  Google Scholar 

  5. McMahon AJ, Buckley J, Taylor A, Lloyd SN, Deane RF, Kirk D. Chronic testicular pain following vasectomy. Br J Urol. 1992;69:188–91.

    Article  CAS  PubMed  Google Scholar 

  6. Ishigami K, Abu-Yousef MM, El-Zein Y. Tubular ectasia of the epididymis: a sign of postvasectomy status. J Clin Ultrasound. 2005;33:447–51.

    Article  PubMed  Google Scholar 

  7. Reddy NM, Gerscovich EO, Jain KA, Le-Petross HT, Brock JM. Vasectomy-related changes on sonographic examination of the scrotum. J Clin Ultrasound. 2004;32:394–8.

    Article  PubMed  Google Scholar 

  8. Cho SH, Min SK, Lee ST. Associations of ultrasonographic features with scrotal pain after vasectomy. Korean J Urol. 2011;52:782–6.

    Article  PubMed  PubMed Central  Google Scholar 

  9. McCammack KC, Aganovic L, Hsieh TC, Guo Y, Welch CS, Gamst AC, Cassidy F. MRI of the epididymis: can the outcome of vasectomy reversal be predicted preoperatively? AJR Am J Roentgenol. 2014;203:91–8.

    Article  PubMed  Google Scholar 

  10. Frates MC, Benson CB, Stober SL. Mobile echogenicities on scrotal sonography: is the finding associated with vasectomy? J Ultrasound Med. 2011;30:1387–90.

    Article  PubMed  Google Scholar 

  11. Amaral F, Dreyer G, Figueredo-Silva J, Noroes J, Cavalcanti A, Samico SC, Santos A, Coutinho A. Live adult worms detected by ultrasonography in human Bancroftian filariasis. Am J Trop Med Hyg. 1994;50:753–7.

    CAS  PubMed  Google Scholar 

  12. Wang Z, Yang Z, Lei YY, Zhang YD, Chen LD, Xie XY, Lu MD, Wang W. Who is doing the dance in epididymis: the principle of moblile echogenicities without filarial infection: case report. Medicine (Baltimore). 2015;94(34):e1418.

    Article  Google Scholar 

  13. Bykov VL. Paneth cells: history of discovery, structural and functional characteristics and the role in the maintenance of homeostasis in the small intestine. Morfologiia. 2014;145:67–80.

    CAS  PubMed  Google Scholar 

  14. Nistal M, Mariño-Enríquez A, De Miguel MP. Granular changes (Paneth cell-like) in epididymal epithelial cells are lysosomal in nature and are not markers of obstruction. Histopathology. 2007;50:944–7.

    Article  CAS  PubMed  Google Scholar 

  15. Shah VI, Ro JY, Amin MB, Mullick S, Nazeer T, Ayala AG. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg Pathol. 1998;22:990–6.

    Article  CAS  PubMed  Google Scholar 

  16. Nistal M, Mate A, Paniagua R. Granulomatous epididymal lesion of possible ischemic origin. Am J Surg Pathol. 1997;21:951–6.

    Article  CAS  PubMed  Google Scholar 

  17. Mitchinson MJ, Sherman KP, Stainer-Smith AM. Brown patches in the epididymis. J Pathol. 1975;115:57–62.

    Article  CAS  PubMed  Google Scholar 

  18. Regadera J, Nistal M, Paniagua R. Testis, epididymis, and spermatic cord in elderly men. Correlation of angiographic and histologic studies with systemic arteriosclerosis. Arch Pathol Lab Med. 1985;109:663–7.

    CAS  PubMed  Google Scholar 

  19. Fulton RS, Rouse RV, Ranheim EA. Ectopic prostate: case report of a presacral mass presenting with obstructive symptoms. Arch Pathol Lab Med. 2001;125:286–8.

    CAS  PubMed  Google Scholar 

  20. Tekin K, Sungurtekin U, Aytekin FO, Calli N, Erdem E, Ozden A, Yalcin N. Ectopic prostatic tissue of the anal canal presenting with rectal bleeding: report of a case. Dis Colon Rectum. 2002;45:979–80.

    Article  PubMed  Google Scholar 

  21. Bromberg WD, Kozlowski JM, Oyasu R. Prostate-type gland in the epididymis. J Urol. 1991;145:1273–4.

    CAS  PubMed  Google Scholar 

  22. Lee LY, Tzeng J, Grosman M, Unger PD. Prostate gland-like epithelium in the epididymis: a case report and review of the literature. Arch Pathol Lab Med. 2004;128:e60–2.

    PubMed  Google Scholar 

  23. VanBeek CA, Peters CA, Vargas SO. Ectopic prostate tissue within the processus vaginalis: insights into prostate embryogenesis. Pediatr Dev Pathol. 2005;8:379–85.

    Article  PubMed  Google Scholar 

  24. McNeal JE. Prostate anatomy and BPH morphogenisis. Prog Clin Biol Res. 1984;145:27–54.

    CAS  PubMed  Google Scholar 

  25. De Miguel MP, Mariño JM, Gonzalez-Peramato P, Nistal M, Regadera J. Epididymal growth and differentiation are altered in human cryptorchidism. J Androl. 2001;22:212–25.

    CAS  PubMed  Google Scholar 

  26. Aydin A, Aksoy HZ, Reis A, Ozdemir F. Undifferentiated carcinoma of the epididymis. Acta Clin Croat. 2011;50:415–8.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Manuel Nistal .

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Nistal, M., González-Peramato, P., Serrano, Á. (2017). Reactive Pathology of the Epididymis. In: Clues in the Diagnosis of Non-tumoral Testicular Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-49364-0_33

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-49364-0_33

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-49363-3

  • Online ISBN: 978-3-319-49364-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics