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Testicular Dysgenesis Syndrome (TDS)

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Clues in the Diagnosis of Non-tumoral Testicular Pathology

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Abstract

In recent decades, epidemiological evidence of an increase of certain diseases of the male reproductive tract, such as testicular germ cell tumors, cryptorchidism, infertility, and hypospadias in industrialized countries, has suggested the hypothesis of the presence of a common testicular abnormality for which the name of testicular dysgenesis syndrome has been proposed. Studies have been routed in several lines of research: (a) identify the factors (endocrine disruptors) that promote the onset of these diseases, (b) specify the cellular mechanisms through which these factors act altering the fetal physiology, and (c) identify testicular lesions they produce what, although in varying degrees, might be common to all four pathologies. After a summary of the incidence of various pathologies and the most frequent endocrine disruptors that affect testicular physiology, this chapter also exposes the testicular histological findings (mixed atrophy, hypoplastic tubules, Sertoli cell nodules, granular changes in Sertoli cells, tubules with germ cell hypoplasia, microlithiasis, focal Leydig cell hyperplasia, and germ cell neoplasia in situ) that enable to suggest that a patient has a testicular dysgenesis syndrome.

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Authors and Affiliations

  1. Universidad Autónoma de Madrid (UAM), Department of Anatomy, Histology and Neuroscience, School of Medicine, Madrid, Spain

    Manuel Nistal

  2. School of Medicine, Universidad Autónoma de Madrid (UAM), University Hospital La Paz, Department of Pathology, Madrid, Spain

    Pilar González-Peramato

  3. University Hospital Clinico San Carlos, Department of Urology, Madrid, Spain

    Álvaro Serrano

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  1. Manuel Nistal
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  2. Pilar González-Peramato
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  3. Álvaro Serrano
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Correspondence to Manuel Nistal .

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Nistal, M., González-Peramato, P., Serrano, Á. (2017). Testicular Dysgenesis Syndrome (TDS). In: Clues in the Diagnosis of Non-tumoral Testicular Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-49364-0_13

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  • DOI: https://doi.org/10.1007/978-3-319-49364-0_13

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-49363-3

  • Online ISBN: 978-3-319-49364-0

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