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Ceramide-1-Phosphate and Its Role in Trafficking of Normal Stem Cells and Cancer Metastasis

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Lipidomics of Stem Cells

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

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Abstract

Ceramide-1-phosphate (C1P), together with other sphingolipids, plays a crucial role in regulating several cell functions. Solid evidence has accumulated that C1P can induce proliferation of some types of cells, regulates inflammation and phagocytosis, has anti-apoptotic properties, and is a potent chemoattractant for variety of cells including stem cells and cancer cells. Unlike most studied peptide-based chemoattractants which show activity in experimental models at supraphysiological concentrations, C1P can activate cell migration within physiological concentration range. Moreover, C1P level may be upregulated in damaged tissues due to injury, ischemia, irradiation, or as a toxic effect of chemotherapy. Therefore, CIP as therapeutic target has important implication for optimizing stem cells mobilization and homing, tissue and organ regeneration, and preventing cancer metastasis.

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Abbreviations

BM:

Bone marrow

C1P:

Ceramide-1-phosphate

CERK:

Ceramide kinase

EPC:

Endothelial progenitor cells

FGF-2:

Fibroblast growth factor-2

HSPC:

Hematopoietic stem/progenitor cell

LPA:

Lysophosphatidic acid

LPC:

Lysophosphatidylocholine

LPP:

Lipid phosphate phosphatase

MAPK:

Mitogen activated protein kinase

MCP-1:

Macrophage chemoattractant protein-1

MMP:

Metalloproteinase

MSC:

Mesenchymal stem cell

mTOR1:

Mammalian target of rapamycin 1

NF-κB:

Nuclear factor kappa B

PA:

Phosphatidic acid

PAH:

Pulmonary artery hypertension

PGE2 :

Prostaglandin E2

PI3-K:

Phosphatidylinositol 3-kinase

PLD:

Phospholipase D

S1P:

Sphingosine-1-phosphate

SDF-1:

α-Chemokine stromal-derived factor 1

SMase:

Sphingomyelinase

VSEL:

Very small embryonic-like stem cell

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Authors and Affiliations

  1. Stem Cell Institute at the James Graham Brown Cancer Center, University of Louisville, 500 S. Floyd Street, Rm. 103, Louisville, KY, 40202, USA

    Gabriela Schneider & Mariusz Z. Ratajczak

  2. Department of Regenerative Medicine, Warsaw Medical University, Warsaw, Poland

    Mariusz Z. Ratajczak

Authors
  1. Gabriela Schneider
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  2. Mariusz Z. Ratajczak
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Correspondence to Gabriela Schneider .

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Editors and Affiliations

  1. The University of Melbourne & Centre for Eye Research Australia, Melbourne, Victoria, Australia

    Alice Pébay

  2. The University of Melbourne & Centre for Eye Research Australia, Melbourne, Victoria, Australia

    Raymond C.B. Wong

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Schneider, G., Ratajczak, M.Z. (2017). Ceramide-1-Phosphate and Its Role in Trafficking of Normal Stem Cells and Cancer Metastasis. In: Pébay, A., Wong, R. (eds) Lipidomics of Stem Cells. Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-49343-5_7

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