Acne Epidemiology and Genetics

  • Gerd Plewig
  • Bodo Melnik
  • WenChieh Chen


There is substantial evidence that hereditary factors play an important role in acne pathogenesis. They enhance the risk for disease or aggravate its course and outcome and modify the time of onset, persistence after puberty, response to treatment, tissue remodeling and healing, the extent of scaring, and the disposition for keloid. Acne genetics have been overestimated during the last decades because a single genetic polymorphism or a rare mutation cannot explain the high and fast raising prevalence rates in adolescents living in developed countries. The high acne prevalence in developed countries underlines the predominance of environmental factors including Western-style nutrition.


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© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Gerd Plewig
    • 1
  • Bodo Melnik
    • 2
  • WenChieh Chen
    • 3
  1. 1.Department of Dermatology and AllergyLudwig-Maximilian-University MunichMunichGermany
  2. 2.Department of Dermatology, Environmental Medicine and Health TheoryUniversity of OsnabrückOsnabrückGermany
  3. 3.Department of Dermatology and AllergyTechnical University of MunichMunichGermany

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