Rosacea Pathogenesis

  • Gerd Plewig
  • Bodo Melnik
  • WenChieh Chen


Multiple factors are involved in rosacea pathogenesis such as disturbed epidermal barrier function, cathelicidin antimicrobial peptide (CAMP)-mediated inflammation with inflammasome activation, aberrations of vascular reactivity, enhanced innate immunity, neurogenic inflammation, angiogenesis, fibrosis, and Demodex mite hypercolonization. The lack of appropriate animal models of rosacea underlines the importance of translational research approaching rosacea pathogenesis.


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Copyright information

© Springer Nature Switzerland AG 2019

Authors and Affiliations

  • Gerd Plewig
    • 1
  • Bodo Melnik
    • 2
  • WenChieh Chen
    • 3
  1. 1.Department of Dermatology and AllergyLudwig-Maximilian-University MunichMunichGermany
  2. 2.Department of Dermatology, Environmental Medicine and Health TheoryUniversity of OsnabrückOsnabrückGermany
  3. 3.Department of Dermatology and AllergyTechnical University of MunichMunichGermany

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