Multiple factors are involved in rosacea pathogenesis such as disturbed epidermal barrier function, cathelicidin antimicrobial peptide (CAMP)-mediated inflammation with inflammasome activation, aberrations of vascular reactivity, enhanced innate immunity, neurogenic inflammation, angiogenesis, fibrosis, and Demodex mite hypercolonization. The lack of appropriate animal models of rosacea underlines the importance of translational research approaching rosacea pathogenesis.
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