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Natural History of Pediatric Indeterminate Colitis

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Pediatric Inflammatory Bowel Disease

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Abstract

Indeterminate colitis (IC), as a classification of inflammatory bowel disease, was introduced by Kent in 1970 [1] and was intended to classify colectomy specimens that had histology findings suggestive of Crohn’s disease (CD), despite a patient’s clinical history of ulcerative colitis (UC). The 2014 Porto Criteria established new terminology, inflammatory bowel disease unclassified (IBD-U), to reduce confusion among providers, researchers, and patients [2]. Contemporarily, IBD-U is used broadly for patients whose clinical, radiological, endoscopic, and histological findings provide a muddled picture. In this chapter, we review the clinical and histological criteria needed to establish the diagnosis of inflammatory bowel disease unclassified (IBD-U), describe the factors that lead to the diagnosis of IBD-U, investigate occurrence of reclassification, and review the available literature about the natural history of this classification.

Melissa A. Fernandes and Sofia Verstraete were supported in part by NIH Grant T32 DK007762.

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Abbreviations

CD:

Crohn’s disease

IBD:

Inflammatory bowel disease

IBD-U:

Inflammatory bowel disease unclassified

IC:

Indeterminate colitis

UC:

Ulcerative colitis

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Author information

Authors and Affiliations

  1. Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA

    Melissa A. Fernandes MD, Sofia Verstraete MD & Melvin B. Heyman MD

  2. Pediatric Gastroenterology/Nutrition, University of California, San Francisco, 550-16th Street, fifth floor, Mailstop 0136, San Francisco, CA, 94143, USA

    Melvin B. Heyman MD

Authors
  1. Melissa A. Fernandes MD
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  2. Sofia Verstraete MD
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  3. Melvin B. Heyman MD
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Corresponding author

Correspondence to Melvin B. Heyman MD .

Editor information

Editors and Affiliations

  1. Division of GI, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Petar Mamula

  2. Division of GI, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Andrew B. Grossman

  3. Division of GI, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Robert N. Baldassano

  4. Division of GI, Hepatology & Nutrition, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

    Judith R. Kelsen

  5. Division of Pediatric Gastroenterology & Nutrition, University of South Carolina School of Medicine - Greenville, Greenville, South Carolina, USA

    Jonathan E. Markowitz

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Fernandes, M.A., Verstraete, S., Heyman, M.B. (2017). Natural History of Pediatric Indeterminate Colitis. In: Mamula, P., Grossman, A., Baldassano, R., Kelsen, J., Markowitz, J. (eds) Pediatric Inflammatory Bowel Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-49215-5_9

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  • DOI: https://doi.org/10.1007/978-3-319-49215-5_9

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  • Online ISBN: 978-3-319-49215-5

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