Abstract
Video capsule endoscopy provides a noninvasive method for the complete endoscopic evaluation of the small bowel mucosa. Its performance has been shown to outperform other imaging modalities for the detection of mucosal lesions. Indications for a video capsule in inflammatory bowel disease (IBD) include the diagnosis of suspected (obscure) small bowel Crohn disease (CD), determination of the extent and severity of small bowel involvement in established Crohn disease, evaluation of unexplained symptoms in established IBD, evaluation of the presence of small bowel lesions in patients with colonic IBD (ulcerative or indeterminate colitis, IBD-U), evaluation of mucosal healing of small bowel Crohn disease after treatment, assessment of possible postoperative recurrence of small bowel Crohn, incomplete colonoscopy, and the assessment of pouchitis. Video capsule in patients with suspected or established Crohn disease is safe, and the results often have a significant clinical impact. However, the foremost contraindication to capsule use is the presence of a known or suspected intestinal obstruction and/or strictures because of the risk of capsule retention. The advent of patency capsules can reduce the risk as a video capsule performed after a positive patency capsule test in patients with Crohn disease is associated with a high risk of video capsule retention. Other practical issues discussed are the use of bowel cleansing preps and prokinetic agents as well as size and age limitations of video capsule use in children.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Lenaerts C, Roy CC, Vaillancourt M, Weber AM, Morin CL, Seidman E. High incidence of upper GI tract involvement in children with Crohn disease. Pediatrics. 1989;83:777–81.
Levine A, Koletzko S, Turner D, Escher JC, Cucchiara S, de Ridder L, et al. ESPGHAN revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents. J Pediatr Gastroenterol Nutr. 2014;58:795–806.
Yamamoto H, Kita H, Sunada K, et al. Clinical outcomes of double-balloon endoscopy for the diagnosis and treatment of small-intestinal diseases. Clin Gastroenterol Hepatol. 2004;2:1010–6.
Nishimura N, Yamamoto H, Yano T, et al. Safety and efficacy of double-balloon enteroscopy in pediatric patients. Gastrointest Endosc. 2008;71:287–94.
Guilhon de Araujo Sant’Anna AM, Dubois J, Miron MJ, Seidman EG. Wireless capsule endoscopy for obscure small bowel disorders: final results of the first pediatric controlled trial. Clin Gastroenterol Hepatol. 2005;3:264–270.
Kopylov U, Seidman EG. Role of capsule endoscopy in inflammatory bowel disease. World J Gastroenterol. 2014;20:1155–64.
Zeviit N, Shamir R. Wireless capsule endoscopy of the small intestine in children. J Pediatr Gastroenterol Nutr. 2015;60:696–701.
Marmo R, Rotondano G, Piscopo R, Bianco MA, Cipolletta L. Meta-analysis: capsule enteroscopy vs. conventional modalities in diagnosis of small bowel diseases. Aliment Pharmacol Ther. 2005;22:595–604.
Golder SK, Schreyer AG, Endlicher E, Feuerbach S, Scholmerich J, Kullmann F, Seitz J, Rogler G, Herfarth H. Comparison of capsule endoscopy and magnetic resonance (MR) enteroclysis in suspected small bowel disease. Int J Color Dis. 2006;21:97–104.
Albert JG, Martiny F, Krummenerl A, et al. Diagnosis of small bowel Crohn disease: a prospective comparison of capsule endoscopy with magnetic resonance imaging and fluoroscopic enteroclysis. Gut. 2005;54:1721–7.
Solem CA, Loftus Jr EA, Fletcher JG, et al. Small-bowel imaging in Crohn’s disease: a prospective, blinded, 4-way comparison trial. Gastrointest Endosc. 2008;68:255–66.
Leighton J, Legnani P, Seidman EG. Role of capsule endoscopy in inflammatory bowel disease: where we are and where we are going. Inflamm Bowel Dis. 2007;13:331–7.
Cohen SA. Pediatric capsule endoscopy. Tech Gastrointest Endosc. 2013;15:32–5.
Arguelles-Arias F, Donat E, Fernandez-Urien I, Alberca F, Arguelles-Matin F, Marinez MJ, et al. Guideline for wireless capsule endoscopy in children and adolescents. Rev Esp Enferm Dig (Madrid). 2016;107:714–31.
Triester SL, Leighton JA, Leontiadis GI, et al. A meta-analysis of capsule endoscopy (CE) compared to other modalities in patients with non-stricturing small bowel Crohn disease. Am J Gastroenterol. 2006;101:954–64.
Aloi M, Di Naardo G, Romano G, Casciani E, Civitelli F, Oliva S, et al. Magnetic resonance enterography, small intestine contrast ultrasound, and capsule endoscopy to evaluate the small bowel in pediatric Crohn’s disease: a prospective, blinded comparison study. Gastrointest Endosc. 2015;81:420–7.
Goldfarb NI, Pizzi LT, Fuhr Jr JP, et al. Diagnosing Crohn disease: an economic analysis comparing wireless capsule endoscopy with traditional diagnostic procedures. Dis Manag. 2004;7:292–304.
Kopylov U, Nemeth A, Koulaouzidis A, Makins R, Wild G, Afif W, et al. Small bowel capsule endoscopy in the management of established Crohn’s disease: clinical impact, safety and correlation with inflammatory biomarkers. Inflamm Bowel Dis. 2015;21:93–100.
Pons Beltran V, Nos P, Bastida G, et al. Evaluation of postsurgical recurrence in Crohn’s disease: a new indication for capsule endoscopy? Gastrointest Endosc. 2007;66:533–40.
Bourreille A, Jarry M, D’Halluin PN, et al. Wireless capsule endoscopy versus ileocolonoscopy for the diagnosis of postoperative recurrence of Crohn disease: a prospective study. Gut. 2006;55:978–83.
Biancone L, Calabrese E, Petruzziello C, et al. Wireless capsule endoscopy and small intestine contrast ultrasonography in recurrence of Crohn’s disease. Inflamm Bowel Dis. 2007;13:1256–65.
Lo SK, Zaidel O, Tabibzadeh S, et al. Utility of wireless capsule enteroscopy (WCE) and IBD serology in re-classifying indeterminate colitis (IC). Gastroenterology. 2003;124:S1310.
Mehdizadeh S, Chen G, Enayati PJ, et al. Diagnostic yield of capsule endoscopy in ulcerative colitis and inflammatory bowel disease of unclassified type (IBDU). Endoscopy. 2008;40(1):30–5.
Di Nardo G, Oliva S, Ferrari F, et al. Usefulness of wireless capsule endoscopy in paediatric inflammatory bowel disease. Dig Liver Dis. 2011;43:220–4.
Bouguen G, Levesque BG, Pola S, Evans E, Sandborn WJ. Endoscopic assessment and treating to target increase the likelihood of mucosal healing in patients with Crohn’s disease. Clin Gastroenterol Hepatol. 2014;12:978–85.
Efthymiou A, Viazis N, Mantzaris G, et al. Does clinical response correlate with mucosal healing in patients with Crohn’s disease of the small bowel? A prospective, case-series study using wireless capsule endoscopy. Inflamm Bowel Dis. 2008;14:1542–7.
Calabrese C, Gionchetti P, Rizzello F, et al. Short-term treatment with infliximab in chronic refractory pouchitis and ileitis. Aliment Pharmacol Ther. 2008;27:759–6.
Seidman EG, Kopylov U, Chao CY, Girardin M, Starr M. Capsule endoscopy reveals small intestinal mucosal Crohn’s disease healing after treatment with adalimumab: preliminary results of the SIMCHA Study. Gastroenterology. 2016;150:S996.
Gralnek I, Defranchis R, Seidman E, Leighton JA, Legnani P, Lewis BS. Development of a capsule endoscopy scoring index for small bowel mucosal inflammatory change. Aliment Pharmacol Ther. 2008;22:146–54.
Arguelles-Arias F, Caunedo A, Romero J, et al. The value of capsule endoscopy in pediatric patients with a suspicion of Crohn disease. Endoscopy. 2004;36:869–73.
Barkay O, Moshkowitz M, Reif S. Crohn disease diagnosed by wireless capsule endoscopy in adolescents with abdominal pain, protein-losing enteropathy, anemia and negative endoscopic and radiologic findings. Isr Med Assoc J. 2005;7:216–8.
Goldstein J, Eisen GM, Lewis B, et al. Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo. Clin Gastroenterol Hepatol. 2005;3:133–41.
Nishimura N, Yamamoto H, Yano T, et al. Safety and efficacy of double-balloon enteroscopy in pediatric patients. Gastrointest Endosc. 2010;71:287–94.
Danialifar TF, Naon H, Liu QY. Comparison of diagnostic accuracy and concordance of video capsule endoscopy and double balloon enteroscopy in children. J Pediatr Gastroenterol Nutr. 2016;62(6):824–7.
Min SB, Le-Carlson M, Singh N, Nylund CM, Gebbia J, Haas K, et al. Video capsule endoscopy impacts decision making in pediatric inflammatory bowel disease: a single tertiary care center experience. Inflamm Bowel Dis. 2013;19:2139–49.
Cohen SA, Ephrath H, Lewis JD, Klevens A, Bergwek A, Liu S, et al. Pediatric capsule endoscopy: review of the small bowel and patency capsules. J Pediatr Gastroenterol Nutr. 2012;54:409–13.
Gay G, Delvaux M, Laurent V, et al. Temporary intestinal occlusion induced by a "patency capsule" in a patient with Crohn disease. Endoscopy. 2005;37:174–7.
Nemeth A, Kopylov U, Koulaouzidis A, Wurm Johansson G, Thorlacius H, Amre D, et al. Use of patency capsule in patients with established Crohn’s disease. Endoscopy. 2016;16:373–9.
Mathus-Vliegen E, Pellisé M, Heresbach D, Fischbach W, Dixon T, Belsey J, et al. Consensus guidelines for the use of bowel preparation prior to colonic diagnostic procedures: colonoscopy and small bowel video capsule endoscopy. Curr Med Res Opin. 2013;29:931–45.
Oliva S, Cuccchiara S, Spada C, Hassan C, Ferrari F, Civitelli F, et al. Small bowel cleansing for capsule endoscopy in paediatric patients: a prospective random single-blind study. Dig Liver Dis. 2014;46:51–5.
Klein A, Dashkovsky M, Gralnek I, Peled R, Chowers Y, Khamaysi I, Har-Noy O, Levi I, Nadler M, Eliakim R, Kopylov U. Bowel preparation in "real-life" small bowel capsule endoscopy: a two-center experience. Ann Gastroenterol. 2016;29(2):196–200. doi:10.20524/aog.2016.0012.
Hookey L, Louw J, Wiepjes M, Rubinger N, Van Weyenberg S, Day AG, Paterson W. Lack of benefit of active preparation compared with a clear fluid–only diet in small-bowel visualization for video capsule endoscopy: results of a randomized, blinded, controlled trial. Gastrointestinal Endoscopy. 2017;85(1):187–93.
Villa F, Signorelli C, Rondonotti E, et al. Preparations and prokinetics. Gastrointest Endosc Clin N Am. 2006;16:211–20.
Keuchel M, Dirks MH, Seidman EG. Swallowing and motility disorders, pacemakers & obesity. In: Keuchel M, Hagenmüller F, Fleischer D, editors. Atlas of video capsule endoscopy. Wurzburg: Springer; 2006. p. 24–9.
Fritscher-Raven A, Scherbakov P, Bufler P, et al. The feasibility of capsule endoscopy in detecting small intestinal pathology in children under age 8 years: a multicentre European study. Gut. 2009;58:1467–72.
Oikawa-Kawamoto M, Sogo T, Yamaguchi T, Tsunoda T, Kondo T, Komatsu H, et al. Safety and utility of capsule endoscopy for infants and young children. World J Gastroenterol. 2013;19:8342–8.
Hosoe N. Makoto Naganuma, Haruhiko Ogata. 2015. Current status of capsule endoscopy through a whole digestive tract. Dig Endosc. 2015;27:205–15.
Oliva S, Nardo GD, Cucchiara S, Gualdi G, Casciani E, Cohen SA. Capsule endoscopy in pediatrics: a 10-years journey. World J Gastroenterol. 2014;20:16603–8.
Oliva S, Cucchiara S, Civitelli F, Casciani E, Di Nardo G, Hassan C, et al. Colon capsule endoscopy compared with other modalities in the evaluation of pediatric Crohn’s disease of the small bowel and colon. Gastrointest Endosc. 2016;83:975–83.
Hijaz NM, Septer SS, Attard TM. Present standard in pediatric gastroenterology fellowship training in the interpretation of capsule endoscopy. J Pediatr Gastroenterol Nutr. 2015;61:421–3.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this chapter
Cite this chapter
Seidman, E.G., Chao, C.Y., Sant’Anna, A.M. (2017). Video Capsule Endoscopy in Inflammatory Bowel Disease. In: Mamula, P., Grossman, A., Baldassano, R., Kelsen, J., Markowitz, J. (eds) Pediatric Inflammatory Bowel Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-49215-5_23
Download citation
DOI: https://doi.org/10.1007/978-3-319-49215-5_23
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-49213-1
Online ISBN: 978-3-319-49215-5
eBook Packages: MedicineMedicine (R0)