Abstract
The article presents the results of a study of the effects on irradiated (1 Gy) mice and rats of the natural chemosignals excreted with the urine of healthy mice. It is shown that exposure to such natural chemosignals increases in the irradiated mice the activity of humoral immune response to thymus-dependent antigen and stimulates the phagocytosis of peritoneal macrophages. In the exposed rats the cellularity indicators of peripheral blood are restored. It was also found that the exposure of intact mice to the post-radiation (4 Gy) volatile components before immunization with thymus-dependent antigen leads to the depression of the immune reactivity of recipients. The same effect after immunization, in the productive phase of immune response, is accompanied by its stimulation. The role of chemosignaling in the realization of the bystander effect during communications between irradiated and intact animals is analyzed. The hypothesis of the significance and advisability of the bystander effect for increasing the survival of animals in groups is discussed.
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Surinov, B.P., Isaeva, V.G., Dukhova, N.N., Kaprin, A.D. (2016). The Significance of Chemosignaling Between Irradiated and Non-irradiated Organisms in Bystander Effect. In: Korogodina, V., Mothersill, C., Inge-Vechtomov, S., Seymour, C. (eds) Genetics, Evolution and Radiation. Springer, Cham. https://doi.org/10.1007/978-3-319-48838-7_17
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DOI: https://doi.org/10.1007/978-3-319-48838-7_17
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