Mathematical Analysis of Regulatory Networks and Damage Repair Efficiency in Bacterial Cells
An extended mathematical model of the UV-induced mutation process in E. coli bacterial cells has been developed. It describes the whole sequence of molecular events involved in nucleotide excision repair of initial damage, replication kinetics and postreplication repair. The model provides ab initio calculation of the number of mismatches as a result of translesion synthesis for both wild type and repair-deficient mutant cells. A comparison of efficiency of different repair systems has been carried out.
KeywordsUV mutagenesis Replication Nucleotide excision repair Recombination repair SOS response Translesion synthesis Escherichia coli
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