Why Do Former Preterm Infants Wheeze? Clues from the Laboratory

  • Richard J. MartinEmail author
  • Thomas M. Raffay
Part of the Respiratory Medicine book series (RM)


Increased airway reactivity is a major challenge in former preterm infants across the spectrum of gestational ages. It is, therefore, imperative that underlying mechanisms be addressed, and this is probably best done in neonatal animal models. Available evidence points to multiple anatomic and neural contributors to longer lasting airway hyperreactivity elicited by neonatal lung injury, especially hyperoxic exposure. Future studies need to address the interplay of exposure to supplemental oxygen with antenatal and postnatal inflammation as well as the pressure effects elicited by various ventilatory modes to which the immature lung and airway are exposed.


Immature airway Hyperoxic exposure Airway smooth muscle development 


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Case Western Reserve University School of MedicineClevelandUSA
  2. 2.Rainbow Babies & Children’s HospitalClevelandUSA

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