Sleep Outcomes in Children Born Prematurely

  • Kristie R. Ross
  • Susan Redline
Part of the Respiratory Medicine book series (RM)


Emergence of sleep states and maturation of control of breathing during sleep and wake are critical developmental milestones. These important developmental trajectories may be adversely affected by the direct impact of premature birth, by comorbid conditions, by neonatal treatments, and by environmental and treatment-related exposures in the perinatal period. Disorders of respiratory control, including sudden infant death syndrome and obstructive sleep apnea syndrome, are more common in infants and children born prematurely. The effects of prematurity on disordered breathing during sleep are most apparent in young children, while effects on circadian rhythm persist into adulthood.


Prematurity Bronchopulmonary dysplasia Sleep-disordered breathing Obstructive sleep apnea Circadian rhythm Infancy Childhood Adolescence Adulthood 



Apnea hypopnea index


Apnea index


Active sleep


Body mass index


Bronchopulmonary dysplasia


Nonrapid eye movement


Obstructive sleep apnea syndrome




Quiet sleep


Respiratory disturbance index


Rapid eye movement


Sleep-disordered breathing


Sudden infant death syndrome


Upper airway resistance syndrome


Very low birth weight


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Kristie R. Ross
    • 1
  • Susan Redline
    • 2
  1. 1.Case Western Reserve University School of MedicineRainbow Babies and Children’s HospitalClevelandUSA
  2. 2.Harvard Medical SchoolBrigham and Women’s Hospital and Beth Israel Deaconess Medical CenterBostonUSA

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