Abstract
Neuropilins are receptors for all but one secreted (class 3) Semaphorins. The exception is Sema3E that directly binds and activates the Plexin-D1 receptor to induce cell repulsion. In this chapter, we review works that identified an unexpected role of Neuropilin-1 as a gating switch in Sema3E/Plexin-D1 signaling, that converts repulsion into attraction, and discuss the implications of this finding for brain wiring.
Keywords
- Vascular Endothelial Cell Growth Factor
- Axon Guidance Molecule
- Attractive Signaling
- Papez Circuit
- Attractive Response
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Acknowledgments
This work was supported by the Centre National de la Recherche Scientifique (CNRS), by Aix-Marseille Université, and by grants from the Agence Nationale de la Recherche (ANR-06-JCJC-0094-01, ANR-10-BLAN-1412, ANR-12-BSV4-0012-01), Fédération pour la Recherche sur le Cerveau, Fondation ARC, Institut National du Cancer (2011-139), Association Française contre les Myopathies, Fondation NRJ Institut de France, Fondation pour la Recherche Médicale (DEQ20150331728), and Institut Universitaire de France.
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Mann, F., Chauvet, S. (2017). Neuropilin-Dependent Signaling and Neuropilin-Independent Signaling of the Guidance Molecule Sema3E. In: Neufeld, G., Kessler, O. (eds) The Neuropilins: Role and Function in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-48824-0_5
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DOI: https://doi.org/10.1007/978-3-319-48824-0_5
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