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Introduction and Brief Historical Overview

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The Neuropilins: Role and Function in Health and Disease

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References

  1. Takagi S, Tsuji T, Amagai T, Takamatsu T, Fujisawa H (1987) Specific cell surface labels in the visual centers of Xenopus laevis tadpole identified using monoclonal antibodies. Dev Biol 122:90–100

    Article  CAS  PubMed  Google Scholar 

  2. Takagi S, Hirata T, Agata K, Mochii M, Eguchi G, Fujisawa H (1991) The A5 antigen, a candidate for the neuronal recognition molecule, has homologies to complement components and coagulation factors. Neuron 7:295–307

    Article  CAS  PubMed  Google Scholar 

  3. Takagi S, Kasuya Y, Shimizu M, Matsuura T, Tsuboi M, Kawakami A, Fujisawa H (1995) Expression of a cell adhesion molecule, neuropilin, in the developing chick nervous system. Dev Biol 170:207–222

    Article  CAS  PubMed  Google Scholar 

  4. Fujisawa H, Takagi S, Hirata T (1995) Growth-associated expression of a membrane protein, neuropilin, in Xenopus optic nerve fibers. Dev Neurosci 17:343–349

    Article  CAS  PubMed  Google Scholar 

  5. Kolodkin AL, Levengood DV, Rowe EG, Tai YT, Giger RJ, Ginty DD (1997) Neuropilin is a semaphorin III receptor. Cell 90:753–762

    Article  CAS  PubMed  Google Scholar 

  6. He Z, Tessier-Lavigne M (1997) Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. Cell 90:739–751

    Article  CAS  PubMed  Google Scholar 

  7. Goodman CS, Kolodkin AL, Luo Y, Pueschel AW, Raper JA (1999) Unified nomenclature for the semaphorins collapsins. Cell 97:551–552

    Article  Google Scholar 

  8. Rehman M, Tamagnone L (2013) Semaphorins in cancer: biological mechanisms and therapeutic approaches. Semin Cell Dev Biol 24:179–189

    Article  CAS  PubMed  Google Scholar 

  9. Luo Y, Raible D, Raper JA (1993) Collapsin: a protein in brain that induces the collapse and paralysis of neuronal growth cones. Cell 75:217–227

    Article  CAS  PubMed  Google Scholar 

  10. Chen H, Chedotal A, He Z, Goodman CS, Tessier-Lavigne M (1997) Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron 19:547–559

    Article  CAS  PubMed  Google Scholar 

  11. Huber AB, Kolodkin AL, Ginty DD, Cloutier JF (2003) Signaling at the growth cone: ligand-receptor complexes and the control of axon growth and guidance. Annu Rev Neurosci 26:509–563

    Article  CAS  PubMed  Google Scholar 

  12. Takahashi T, Fournier A, Nakamura F, Wang LH, Murakami Y, Kalb RG, Fujisawa H, Strittmatter SM (1999) Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. Cell 99:59–69

    Article  CAS  PubMed  Google Scholar 

  13. Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (1999) Plexins are a large family of receptors for transmembrane, secreted and GPI-anchored semaphorins in vertebrates. Cell 99:71–80

    Article  CAS  PubMed  Google Scholar 

  14. Gitay-Goren H, Cohen T, Tessler S, Soker S, Gengrinovitch S, Rockwell P, Klagsbrun M, Levi BZ, Neufeld G (1996) Selective binding of VEGF121 to one of the three VEGF receptors of vascular endothelial cells. J Biol Chem 271:5519–5523

    Article  CAS  PubMed  Google Scholar 

  15. Soker S, Takashima S, Miao HQ, Neufeld G, Klagsbrun M (1998) Neuropilin-1 is expressed by endothelial and tumor cells as an isoform specific receptor for vascular endothelial growth factor. Cell 92:735–745

    Article  CAS  PubMed  Google Scholar 

  16. Gluzman-Poltorak Z, Cohen T, Herzog Y, Neufeld G (2000) Neuropilin-2 and Neuropilin-1 are receptors for 165-amino acid long form of vascular endothelial growth factor (VEGF) and of placenta growth factor-2, but only neuropilin-2 functions as a receptor for the 145 amino acid form of VEGF. J Biol Chem 275:18040–18045

    Article  CAS  PubMed  Google Scholar 

  17. Gluzman-Poltorak Z, Cohen T, Shibuya M, Neufeld G (2001) Vascular endothelial growth factor receptor-1 and neuropilin-2 form complexes. J Biol Chem 276:18688–18694

    Article  CAS  PubMed  Google Scholar 

  18. Takashima S, Kitakaze M, Asakura M, Asanuma H, Sanada S, Tashiro F, Niwa H, Miyazaki JJ, Hirota S, Kitamura Y, Kitsukawa T, Fujisawa H, Klagsbrun M, Hori M (2002) Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis. Proc Natl Acad Sci U S A 99:3657–3662

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Makinen T, Olofsson B, Karpanen T, Hellman U, Soker S, Klagsbrun M, Eriksson U, Alitalo K (1999) Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1. J Biol Chem 274:21217–21222

    Article  CAS  PubMed  Google Scholar 

  20. Karkkainen MJ, Saaristo A, Jussila L, Karila KA, Lawrence EC, Pajusola K, Bueler H, Eichmann A, Kauppinen R, Kettunen MI, Yla-Herttuala S, Finegold DN, Ferrell RE, Alitalo K (2001) A model for gene therapy of human hereditary lymphedema. Proc Natl Acad Sci U S A 98:12677–12682

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Karpanen T, Heckman CA, Keskitalo S, Jeltsch M, Ollila H, Neufeld G, Tamagnone L, Alitalo K (2006) Functional interaction of VEGF-C and VEGF-D with neuropilin receptors. FASEB J 20:1462–1472

    Article  CAS  PubMed  Google Scholar 

  22. Migdal M, Huppertz B, Tessler S, Comforti A, Shibuya M, Reich R, Baumann H, Neufeld G (1998) Neuropilin-1 is a placenta growth factor-2 receptor. J Biol Chem 273:22272–22278

    Article  CAS  PubMed  Google Scholar 

  23. Xu Y, Yuan L, Mak J, Pardanaud L, Caunt M, Kasman I, Larrivee B, Del TR, Suchting S, Medvinsky A, Silva J, Yang J, Thomas JL, Koch AW, Alitalo K, Eichmann A, Bagri A (2010) Neuropilin-2 mediates VEGF-C-induced lymphatic sprouting together with VEGFR3. J Cell Biol 188:115–130

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Glinka Y, Prud'homme GJ (2008) Neuropilin-1 is a receptor for transforming growth factor {beta}-1 activates its latent form, and promotes regulatory T cell activity. J Leukoc Biol 84:302–310

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Hsieh SH, Ying NW, Wu MH, Chiang WF, Hsu CL, Wong TY, Jin YT, Hong TM, Chen YL (2008) Galectin-1 a novel ligand of neuropilin-1, activates VEGFR-2 signaling and modulates the migration of vascular endothelial cells. Oncogene 27:3746–3753

    Article  CAS  PubMed  Google Scholar 

  26. Sulpice E, Plouet J, Berge M, Allanic D, Tobelem G, Merkulova-Rainon T (2007) Neuropilin-1 and neuropilin-2 act as coreceptors, potentiating proangiogenic activity. Blood 111:2036–2045

    Article  PubMed  Google Scholar 

  27. Pellet-Many C, Frankel P, Evans IM, Herzog B, Junemann-Ramirez M, Zachary IC (2011) Neuropilin-1 mediates PDGF stimulation of vascular smooth muscle cell migration and signalling via p130Cas. Biochem J 435:609–618

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Dhar K, Dhar G, Majumder M, Haque I, Mehta S, Van Veldhuizen PJ, Banerjee SK, Banerjee S (2010) Tumor cell-derived PDGF-B potentiates mouse mesenchymal stem cells-pericytes transition and recruitment through an interaction with NRP-1. Mol Cancer 9:209

    Article  PubMed  PubMed Central  Google Scholar 

  29. Rizzolio S, Rabinoviz N, Rainero E, Lanzetti L, Serini G, Norman JC, Neufeld G, Tamagnone L (2012) Neuropilin-1 dependent regulation of EGF-Receptor signaling. Cancer Res 72:5801–5811

    Article  CAS  PubMed  Google Scholar 

  30. Matsushita A, Gotze T, Korc M (2007) Hepatocyte growth factor-mediated cell invasion in pancreatic cancer cells is dependent on neuropilin-1. Cancer Res 67:10309–10316

    Article  CAS  PubMed  Google Scholar 

  31. Castellani V, De Angelis E, Kenwrick S, Rougon G (2002) Cis and trans interactions of L1 with neuropilin-1 control axonal responses to semaphorin 3A. EMBO J 21:6348–6357

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Falk J, Bechara A, Fiore R, Nawabi H, Zhou H, Hoyo-Becerra C, Bozon M, Rougon G, Grumet M, Puschel AW, Sanes JR, Castellani V (2005) Dual functional activity of semaphorin 3B is required for positioning the anterior commissure. Neuron 48:63–75

    Article  PubMed  Google Scholar 

  33. Fukasawa M, Matsushita A, Korc M (2007) Neuropilin-1 interacts with integrin beta 1 and modulates pancreatic cancer cell growth, survival and invasion. Cancer Biol Ther 6:1173–1180

    Article  CAS  PubMed  Google Scholar 

  34. Fantin A, Maden CH, Ruhrberg C (2009) Neuropilin ligands in vascular and neuronal patterning. Biochem Soc Trans 37:1228–1232

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  35. Tordjman R, Lepelletier Y, Lemarchandel V, Cambot M, Gaulard P, Hermine O, Romeo PH (2002) A neuronal receptor, neuropilin-1, is essential for the initiation of the primary immune response. Nat Immunol 3:477–482

    CAS  PubMed  Google Scholar 

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Acknowledgment

This work was supported by grants from the Israel Science Foundation (ISF) and from the Rappaport Family Institute for Research in the Medical Sciences of Technion (to G.N.).

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Authors and Affiliations

  1. Cancer Research and Vascular Biology Center, The Bruce Rappaport Faculty of Medicine, Technion, Israel Institute of Technology, Haifa, 31096, Israel

    Gera Neufeld & Ofra Kessler

Authors
  1. Gera Neufeld
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  2. Ofra Kessler
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Corresponding author

Correspondence to Gera Neufeld .

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Editors and Affiliations

  1. Department Anatomy and Cell Biology, Israel Institute of Technology Technion, Haifa, Israel

    Gera Neufeld

  2. Department Anatomy and Cell Biology, Israel Institute of Technology Technion, Haifa, Israel

    Ofra Kessler

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Neufeld, G., Kessler, O. (2017). Introduction and Brief Historical Overview. In: Neufeld, G., Kessler, O. (eds) The Neuropilins: Role and Function in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-48824-0_1

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