Sepsis pp 159-183 | Cite as

Organ Dysfunction in Sepsis: Brain, Neuromuscular, Cardiovascular, and Gastrointestinal

  • Brian J. Anderson
  • Mark E. MikkelsenEmail author
Part of the Respiratory Medicine book series (RM)


Sepsis-related organ dysfunction is common, complex, and associated with significant morbidity and mortality. Organ failure manifests in myriad ways in sepsis, mediated by a complex interplay between inflammation and endothelial and coagulation dysfunction incited by the infectious insult. Given the prevalence and life-support strategies frequently required to address sepsis-related respiratory and renal failure, respiratory failure and acute kidney injury are covered in separate chapters. In this chapter, we detail non-pulmonary, non-renal sepsis-associated organ dysfunction. We begin by examining neurologic complications of sepsis, followed by examination of cardiovascular and gastrointestinal organ dysfunction.


Organ dysfunction Sepsis Neurologic dysfunction Coma Delirium Cardiovascular dysfunction Hepatobiliary dysfunction 


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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Pulmonary, Allergy and Critical Care DivisionPerelman School of Medicine at the University of PennsylvaniaPhiladelphiaUSA
  2. 2.Pulmonary, Allergy and Critical Care DivisionPerelman School of Medicine at the University of PennsylvaniaPhiladelphiaUSA

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