Skip to main content

Intravesical Lidocaine in Interstitial Cystitis/Bladder Pain Syndrome

  • Chapter
  • First Online:
  • 966 Accesses

Abstract

The etiology of interstitial cystitis/bladder pain syndrome (IC/BPS) has been described as related to inflammation, mucosal defects, permeability problems, neuro-endocrine abnormalities, genetic disturbances, and/or infection, but the end result becomes a hypersensitivity of the urinary bladder with hallmarks that include exaggerated and abnormal sensory and motor reactions to the presence of urine in the bladder. In some patients, the symptoms progress to debilitating hyperalgesia and allodynia.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   89.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Hanno PM, Burks DA, Clemens JQ, et al. AUA guideline for the diagnosis and treatment of interstitial cystitis/bladder pain syndrome. J Urol. 2011;185:2162.

    Article  PubMed  Google Scholar 

  2. Taneja R. Intravesical lignocaine in the diagnosis of bladder pain syndrome. Int Urogynecol J. 2010;21(3):321–4.

    Article  PubMed  Google Scholar 

  3. Hanno PM. Bladder pain syndrome (interstitial cystitis) and related disorders (Chapter 12). In: Wein AJ, Kavoussi LR, Novick AC, et al., editors. Campbell-Walsh urology. 10th ed. Philadelphia, PA: Saunders; 2012.

    Google Scholar 

  4. Riley J, Boulis N. Molecular mechanisms of pain: a basis for chronic pain and therapeutic approaches based on the cell and the gene. Clin Neurosurg. 2006;53:77–97.

    PubMed  Google Scholar 

  5. Seeman P. The membrane actions of anesthetics and tranquilizers. Pharmacol Rev. 1972;24:583–655.

    CAS  PubMed  Google Scholar 

  6. Yanagi H, Sankawa H, Saito H, Iikura Y. Effect of lidocaine on histamine release and Ca2+ mobilization from mast cells and basophils. Acta Anaesthesiol Scand. 1996;40:1138–44.

    Article  CAS  PubMed  Google Scholar 

  7. Butrick CW. Interstitial cystitis/bladder pain syndrome: management of the pain disorder: a urogynecology perspective. Urol Clin North Am. 2012;39:377–87.

    Article  PubMed  Google Scholar 

  8. Scott DB. Toxic effects of local anesthetic agents on the central nervous system. Br J Anaesth. 1986;58:732–5.

    Article  CAS  PubMed  Google Scholar 

  9. Tucker GT, Mather LE. Properties, absorption, and disposition of local anesthetic agents. In: Cousins MJ, Bridenbaugh PO, Neural ED, editors. Blockage in clinical anesthesia and management of pain. Philadelphia, PA: Lippincott-Raven; 1998. p. 55–86.

    Google Scholar 

  10. Neal JM, Mulroy MF, Weinberg GL. American Society of Regional Anesthesia and Pain Medicine checklist for managing local anesthetic systemic toxicity: 2012 version. Reg Anesth Pain Med. 2012;37(1):16–8.

    Article  PubMed  Google Scholar 

  11. Birch BR, Miller RA. Absorption characteristics of lignocaine following intravesical instillation. Scand J Urol Nephrol. 1994;28:359.

    Article  CAS  PubMed  Google Scholar 

  12. Henry R, Patterson L, Avery N, et al. Absorption of alkalized intravesical lidocaine in normal and inflamed bladders: a simple method for improving bladder anesthesia. J Urol. 2001;165:1900.

    Article  CAS  PubMed  Google Scholar 

  13. Pode D, Zylber-Katz E, Shapiro A. Intravesical lidocaine: topical anesthesia for bladder mucosal biopsies. J Urol. 1992;148:795.

    CAS  PubMed  Google Scholar 

  14. Thrasher JB, Kreder KJ, Peterson NE, et al. Lidocaine as topical anesthesia for bladder mappings and cold-cup biopsies. J Urol. 1993;150:335.

    CAS  PubMed  Google Scholar 

  15. Asklin B, Cassuto J. Intravesical lidocaine in severe interstitial cystitis. Case report. Scand J Urol Nephrol. 1989;23:311–2.

    Article  CAS  PubMed  Google Scholar 

  16. Giannakopoulos X, Champilomatos P. Chronic interstitial cystitis. Successful treatment with intravesical lidocaine. Arch Ital Urol Nefrol Androl. 1992;64(4):337–9.

    CAS  PubMed  Google Scholar 

  17. Quillin RB, et al. Practical use of the new american urological association interstitial cystitis guidelines. Curr Urol Rep. 2012;13(5):394–401.

    Article  PubMed  Google Scholar 

  18. Moldwin R, Brettschneider N. The use of intravesical anesthetics to aid in the diagnosis of interstitial cystitis. Presented at research insights into interstitial cystitis: a basic and clinical science forum, Alexandria, VA, 31 Oct 2003, poster 41.

    Google Scholar 

  19. Lukban JC, Whitmore KE, Sant GR. Current management of interstitial cystitis. Urol Clin North Am. 2002;29:649.

    Article  PubMed  Google Scholar 

  20. Henry R, Morales A, Cahill C. Beyond a simple anesthetic effect: lidocaine in the diagnosis and treatment of interstitial cystitis/bladder pain syndrome. Urology. 2015;85:1025–33.

    Article  PubMed  Google Scholar 

  21. Nickel JC, Moldwin R, Lee S, et al. Intravesical alkalinized lidocaine (PSD597) offers sustained relief from symptoms of interstitial cystitis and painful bladder syndrome. BJU Int. 2009;103:910–8.

    Article  CAS  PubMed  Google Scholar 

  22. Morales A, Emerson L, Nickel JC. Intravesical hyaluronic acid in the treatment of refractory interstitial cystitis. J Urol. 1996;156:45–8.

    Article  CAS  PubMed  Google Scholar 

  23. Engelhardt PF, Morakis N, Daha LK, Esterbauer B, Riedl CR. Long-term results of intravesical hyaluronan therapy in bladder pain syndrome/interstitial cystitis. Int Urogynecol J Pelvic Floor Dysfunct. 2011;22(4):401–5.

    Article  Google Scholar 

  24. Lv YS, Zhou HL, Mao HP, et al. Intravesical hyaluronic acid and alkalinized lidocaine for the treatment of severe painful bladder syndrome/interstitial cystitis. Int Urogynecol J. 2012;23:1715–20.

    Article  PubMed  Google Scholar 

  25. Davis EL, El Khoudary SR, Talbott EO, et al. Safety and efficacy of the use of intravesical and oral pentosan polysulfate sodium for interstitial cystitis: a randomized double-blind clinical trial. J Urol. 2008;179:177.

    Article  CAS  PubMed  Google Scholar 

  26. Parsons CL, Housley T, Schmidt JD, Lebow D. Treatment of interstitial cystitis with intravesical heparin. Br J Urol. 1994;73:504–7.

    Article  CAS  PubMed  Google Scholar 

  27. Parsons CL. Successful downregulation of bladder sensory nerves with combination of heparin and alkalinized lidocaine in patients with interstitial cystitis. Urology. 2005;65:45–8.

    Article  PubMed  Google Scholar 

  28. Welk BK, Teichman JM. Dyspareunia response in patients with interstitial cystitis treated with intravesical lidocaine, bicarbonate, and heparin. Urology. 2008;71:67–70.

    Article  PubMed  Google Scholar 

  29. Nomiya A, Naruse T, Niimi A, et al. On- and post-treatment symptom relief by repeated instillations of heparin and alkalized lidocaine in interstitial cystitis. Int J Urol. 2013;20:1118–22.

    Article  CAS  PubMed  Google Scholar 

  30. Parsons CL, Zupkas P, Proctor J, et al. Alkalinized lidocaine and heparin provide immediate relief of pain and urgency in patients with interstitial cystitis. J Sex Med. 2012;9:207–12.

    Article  CAS  PubMed  Google Scholar 

  31. Nickel JC, Jain P, Shore N, et al. Continuous intravesical lidocaine treatment for interstitial cystitis/bladder pain syndrome: safety and efficacy of a new drug delivery device. Sci Transl Med. 2014;4:143100.

    Google Scholar 

  32. Fontanella UA, Rossi CA, Stephen RL. Iontophoretic local anaesthesia for bladder dilatation in the treatment of interstitial cystitis. Br J Urol. 1992;69:662–3.

    Article  CAS  PubMed  Google Scholar 

  33. Rosamilia A, Dwyer PL, Gibson J. Electromotive drug administration of lidocaine and dexamethasone followed by cystodistension in women with interstitial cystitis. Int Urogynecol J Pelvic Floor Dysfunct. 1997;8:142–5.

    Article  CAS  PubMed  Google Scholar 

  34. Riedl CR, Knoll M, Plas E, Pfluger H. Electromotive drug administration and hydrodis-tention for the treatment of interstitial cystitis. J Endourol. 1998;12:269–72.

    Article  CAS  PubMed  Google Scholar 

  35. Rose AE, Payne CK, Azevedo K. Pilot study of the feasibility of in-office bladder distention using electromotive drug adminstration (EMDA). Neurourol Urodyn. 2005;24:254–60.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to J. Curtis Nickel M.D., F.R.C.S.C. .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Golda, N., Nickel, J.C. (2017). Intravesical Lidocaine in Interstitial Cystitis/Bladder Pain Syndrome. In: Moldwin, R. (eds) Urological and Gynaecological Chronic Pelvic Pain. Springer, Cham. https://doi.org/10.1007/978-3-319-48464-8_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-48464-8_20

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-48462-4

  • Online ISBN: 978-3-319-48464-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics