Abstract
Transposable elements (TEs) are ubiquitous and particularly abundant in mammalian genomes. TE activity contributes to significant genome modeling and impacts the structure and dynamics of the genomes they inhabit. In humans, Long INterspersed element 1 (LINE1 or L1) is the main driver of TE activity and TE-linked mutations. Increasing studies suggest that TE activation result from a host response to environmental stimuli. This chapter presents the main reported environmental parameters that influence L1 retrotransposition. We propose that environmental effects on L1 occur through both transcriptional and posttranscriptional mechanisms.
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Ade, C.M., Servant, G., Morales, M.E., Roy-Engel, A.M. (2017). Environment, Cellular Signaling, and L1 Activity. In: Cristofari, G. (eds) Human Retrotransposons in Health and Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-48344-3_7
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