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Basic Research in Open Abdomen

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Open Abdomen

Part of the book series: Hot Topics in Acute Care Surgery and Trauma ((HTACST))

Abstract

The most studied topics in basic research about open abdomen are the immunological modifications caused by negative pressure therapy, the distribution of negative pressure in the abdominal cavity, its effects on bowel surface, and the development of means to protect intestinal anastomosis in these situations.

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References

  1. Kubiak BD, Albert SP, Gatto LA, et al. Peritoneal negative pressure therapy prevents multiple organ injury in a chronic porcine sepsis and ischemia/reperfusion model. Shock. 2010;34(5):525–34.

    Article  CAS  PubMed  Google Scholar 

  2. Emr B, Sadowsky D, Azhar N. Removal of inflammatory ascites is associated with dynamic modification of local and systemic inflammation along with prevention of acute lung injury: in vivo and in silico studies. Shock. 2014;41(4):317–23.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Norbury KC, Moyer MP. Effect of negative pressure therapy on the inflammatory response of the intestinal microenvironment in a porcine septic model. Mediator Inflamm. 2015;2015:419841.

    Article  CAS  Google Scholar 

  4. Shi J, Xi W, Yi C. Vacuum sealing drainage promotes experimental pig explosive abdomen wound healing. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2014;30(3):312–5.

    PubMed  CAS  Google Scholar 

  5. Suliburk J, Helmer K, Moore F, et al. The gut in systemic inflammatory response syndrome and sepsis. Enzyme systems fighting multiple organ failure. Eur Surg Res. 2008;40:184–9.

    Article  CAS  PubMed  Google Scholar 

  6. Rezende-neto JB, Moore EE, Masuno T, et al. The abdominal compartment syndrome as a second insult during systemic neutrophil priming provokes multiple organ injury. Shock. 2003;20:303–8.

    Article  PubMed  Google Scholar 

  7. Harward TR, Brooks DL, Flynn TC, et al. Multiple organ dysfunction after mesenteric artery revascularization. J Vasc Surg. 1993;18:459–69.

    Article  CAS  PubMed  Google Scholar 

  8. Narita K, Kuwabara Y, Fujii Y. Lung injury after intestinal ischemia-reperfusion may be avoided by reduced absorption of locally produced cytokines. Surg Today. 2004;34:937–42.

    Article  CAS  PubMed  Google Scholar 

  9. Kuethe JW, Midura EF, Rice TC, et al. Peritoneal wash contents used to predict mortality in a murine sepsis model. SJR. 2015;199:211–9.

    Article  Google Scholar 

  10. Delgado A, Sammons A. In vitro pressure manifolding distribution evaluation of ABThera(™) Active Abdominal Therapy System, V.A.C.(®) Abdominal Dressing System, and Barker’s vacuum packing technique conducted under dynamic conditions. SAGE Open Med. 2016;4:2050312115624988.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Bjarnason T, Montgomery A, Hlebowicz J, et al. Pressure at the bowel surface during topical negative pressure therapy of the open abdomen: an experimental study in a porcine model. World J Surg. 2011;35(4):917–23.

    Article  PubMed  Google Scholar 

  12. Lindstedt S, Malmsjö M, Hansson J, et al. Microvascular blood flow changes in the small intestinal wall during conventional negative pressure wound therapy and negative pressure wound therapy using a protective disc over the intestines in laparostomy. Ann Surg. 2012;255(1):171–5.

    Article  PubMed  Google Scholar 

  13. Lindstedt S, Hansson J, Hlebowicz J. Comparative study of the microvascular blood flow in the intestinal wall during conventional negative pressure wound therapy and negative pressure wound therapy using paraffin gauze over the intestines in laparostomy. Int Wound J. 2012;9(2):150–5.

    Article  PubMed  Google Scholar 

  14. Lindstedt S, Malmsjö M, Hansson J, et al. Macroscopic changes during negative pressure wound therapy of the open abdomen using conventional negative pressure wound therapy and NPWT with a protective disc over the intestines. BMC Surg. 2011;11:10.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Lindstedt S, Malmsjö M, Hlebowicz J, et al. Comparative study of the microvascular blood flow in the intestinal wall, wound contraction and fluid evacuation during negative pressure wound therapy in laparostomy using the V.A.C. abdominal dressing and the ABThera open abdomen negative pressure therapy system. Int Wound J. 2015;12(1):83–8.

    Article  PubMed  Google Scholar 

  16. Zhou B, Ren J, Ding C, et al. Protection of colonic anastomosis with platelet-rich plasma gel in the open abdomen. Injury. 2014;45(5):864–8.

    Article  PubMed  Google Scholar 

  17. Zhou B, Ren J, Ding C, et al. Rapidly in situ forming platelet-rich plasma gel enhances angiogenic responses and augments early wound healing after open abdomen. Gastroenterol Res Pract. 2013;2013:926764.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Deng Y, Ren J, Chen G, et al. Tannin-based adhesive for protection of colonic anastomosis in the open abdomen. J Biomater Sci Polym Ed. 2016;17:1–11.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Unit of General and Emergency Surgery, Papa Giovanni XXIII Hospital, P.zza OMS 1, 24128, Bergamo, Italy

    Paola Fugazzola & Giulia Montori

  2. Trauma and Acute Care Surgery, St. Michael’s Hospital, University of Toronto, Toronto, ON, Canada

    Sandro Rizoli & Joao Rezende-Neto

  3. General, Emergency and Trauma Surgery Department, Bufalini Hospital, Cesena, FC, Italy

    Luca Ansaloni & Federico Coccolini

Authors
  1. Paola Fugazzola
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  2. Giulia Montori
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  3. Sandro Rizoli
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  4. Luca Ansaloni
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  5. Joao Rezende-Neto
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  6. Federico Coccolini
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Corresponding author

Correspondence to Federico Coccolini .

Editor information

Editors and Affiliations

  1. General, Emergency and Trauma Surgery Department, Bufalini Hospital, Cesena, Italy

    Federico Coccolini

  2. General Surgery, Virginia Commonvealth University, Richmond, Virginia, USA

    Rao Ivatury

  3. Letterkenny General Hospital, Letterkenny, Donegal, Ireland

    Michael Sugrue

  4. General, Emergency and Trauma Surgery Department, Bufalini Hospital, Cesena, Italy

    Luca Ansaloni

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Fugazzola, P., Montori, G., Rizoli, S., Ansaloni, L., Rezende-Neto, J., Coccolini, F. (2018). Basic Research in Open Abdomen. In: Coccolini, F., Ivatury, R., Sugrue, M., Ansaloni, L. (eds) Open Abdomen. Hot Topics in Acute Care Surgery and Trauma. Springer, Cham. https://doi.org/10.1007/978-3-319-48072-5_2

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  • DOI: https://doi.org/10.1007/978-3-319-48072-5_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-48071-8

  • Online ISBN: 978-3-319-48072-5

  • eBook Packages: MedicineMedicine (R0)

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