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Multiple Sclerosis: Bench to Bedside pp 129–139Cite as

Clinical Neurophysiology of Multiple Sclerosis

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 958))

Abstract

Different neurophysiological methods such as evoked potentials (EP), testing of the autonomic nervous system (ANS) or polysomnography have the potential to detect clinically silent lesions or to confirm the existence of an association between a clinical symptom and multiple sclerosis (MS); previously undetected by MRI. Therefore, in the most recent MRI criteria for the diagnosis of MS (MAGNIMS consensus guidelines), neurophysiological confirmation of optic nerve dysfunction (slowed conduction on visual EP), support dissemination in space and, in patients without concurrent visual symptoms, dissemination in time. In this chapter we will review the existing evidence regarding the role of different neurophysiological tests (specifically the role of EPs, autonomic nervous system testing and sleep testing in MS) in the diagnosis and management of MS.

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Abbreviations

ANS:

autonomic nervous system

BAEP:

brainstem auditory EP

CIS:

clinically isolated syndrome

CMCT:

central motor conduction time

DIS:

dissemination in space

DIT:

dissemination in time

EP:

evoked potentials

HRV:

heart rate variability

mEPs:

Multimodal evoked potentials

MEPs:

motor evoked potentials

MS:

multiple sclerosis

OH:

orthostatic hypotension

ON:

optic neuritis

OSA:

obstructive sleep apnea

PoTS:

orthostatic tachycardia syndrome

RBD:

REM sleep behavior disorder

RLS:

restless legs syndrome

SSEP:

short latency somatosensory EP

VEMP:

vestibular evoked myogenic potentials

VEPs:

pattern reversal visual Eps

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Authors and Affiliations

  1. School of Medicine, University of Zagreb, Zagreb, Croatia

    Mario Habek & Luka Crnošija

  2. Department of Neurology, Referral Center for Autonomic Nervous System Disorders, University Hospital Center Zagreb, Kišpatićeva 12, HR-10000, Zagreb, Croatia

    Mario Habek, Ivan Adamec, Barbara Barun, Tereza Gabelić & Magdalena Krbot Skorić

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  1. Mario Habek
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  2. Ivan Adamec
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  4. Luka Crnošija
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  6. Magdalena Krbot Skorić
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Correspondence to Mario Habek .

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Editors and Affiliations

  1. Department of Neuroscience Research, University of Dammam, Damman, Saudi Arabia

    Alexzander A. A. Asea

  2. Department of Biological, Chemical and Pharmaceutical Sciences and Technologies, University of Palermo, Palermo, Italy

    Fabiana Geraci

  3. Department of Microbiology, Biochemistry & Immunology, Morehouse School of Medicine, Atlanta, Georgia, USA

    Punit Kaur

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Habek, M., Adamec, I., Barun, B., Crnošija, L., Gabelić, T., Krbot Skorić, M. (2017). Clinical Neurophysiology of Multiple Sclerosis. In: Asea, A., Geraci, F., Kaur, P. (eds) Multiple Sclerosis: Bench to Bedside. Advances in Experimental Medicine and Biology, vol 958. Springer, Cham. https://doi.org/10.1007/978-3-319-47861-6_8

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