Network Physiology: From Neural Plasticity to Organ Network Interactions

  • Plamen Ch. IvanovEmail author
  • Kang K. L. Liu
  • Aijing Lin
  • Ronny P. Bartsch
Conference paper
Part of the Springer Proceedings in Physics book series (SPPHY, volume 191)


The fundamental question in the new field of Network Physiology is how physiologic states and functions emerge from networked interactions among diverse physiological systems. We present recent efforts in developing new methodology and theoretical framework adequate to identify and quantify dynamical interactions among systems with very different characteristics and signal outputs. In this chapter, we demonstrate the utility of the novel concept of time delay stability and a first Network Physiology approach: to investigate new aspects of neural plasticity at the level of brain rhythm interactions in response to changes in physiologic state ; to characterize dynamical features of brain-organ communications as a new signature of neuroautonomic control; and to establish basic principles underlying hierarchical reorganization in the network of organ-organ communications for different physiologic states and functions. The presented results are initial steps in developing an atlas of dynamical interactions among key organ systems in the human body.


Frequency Band Network Interaction Granger Causality Sleep Stage Neural Plasticity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



We acknowledge support from W.M. Keck Foundation, National Institutes of Health (NIH Grant 1R01- HL098437), the Office of Naval Research (ONR Grant 000141010078), the US-Israel Binational Science Foundation (BSF Grant 2012219), EC-FP7 Marie Curie Fellowship (IIF 628159).


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Copyright information

© Springer International Publishing AG 2017

Authors and Affiliations

  • Plamen Ch. Ivanov
    • 1
    • 2
    Email author
  • Kang K. L. Liu
    • 1
    • 3
  • Aijing Lin
    • 1
    • 4
  • Ronny P. Bartsch
    • 1
    • 5
  1. 1.Keck Laboratory for Network Physiology, Department of PhysicsBoston UniversityBostonUSA
  2. 2.Harvard Medical School and Division of Sleep MedicineBrigham and Women’s HospitalBostonUSA
  3. 3.Department of NeurologyBeth Israel Deaconess Medical Center, Harvard Medical SchoolBostonUSA
  4. 4.Department of MathematicsBeijing Jiaotong UniversityBeijingChina
  5. 5.Department of PhysicsBar-Ilan UniversityRamat GanIsrael

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