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Novel In Vitro Assay Models to Study Osteogenesis and Chondrogenesis for Human Skeletal Disorders

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Bone Morphogenetic Proteins: Systems Biology Regulators

Part of the book series: Progress in Inflammation Research ((PIR))

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Abstract

Bone morphogenetic proteins (BMPs)/growth and differentiation factors (GDFs) are involved not only in the physiological development of skeletal tissues but also in the pathological conditions in the tissues. Osteogenesis and chondrogenesis during skeletal formation can be studied in vitro using cell lines and primary cultured cells, which are able to differentiate into osteoblasts and chondrocytes in response to BMP/GDF signaling. These in vitro model systems have been applied to the examination of molecular mechanisms of skeletal disorders related to BMPs/GDFs. Moreover, these in vitro model systems are useful for the development of novel treatments for the disorders.

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Acknowledgments

I would like to thank the members of the Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University for their helpful discussions. This work was supported, in part, by JSPS KAKENHI Numbers 15K15556 and 25293326 and a grant-in-aid from the Support Project for the Formation of a Strategic Center in a Private University from the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) (S1311002).

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  1. Division of Pathophysiology, Research Center for Genomic Medicine, Saitama Medical University, 1397-1 Yamane, Hidaka-shi, Sa-tama, 350-1241, Japan

    Takenobu Katagiri

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Correspondence to Takenobu Katagiri .

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  1. School of Medicine, University of Zagreb, Zagreb, Croatia

    Slobodan Vukicevic

  2. perForm Biologics Inc, Holliston, Massachusetts, USA

    Kuber T. Sampath

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Katagiri, T. (2017). Novel In Vitro Assay Models to Study Osteogenesis and Chondrogenesis for Human Skeletal Disorders. In: Vukicevic, S., Sampath, K. (eds) Bone Morphogenetic Proteins: Systems Biology Regulators. Progress in Inflammation Research. Springer, Cham. https://doi.org/10.1007/978-3-319-47507-3_5

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