Abstract
BMPs regulate multiple essential processes contributing to the formation and homeostasis of the vascular system. Here we describe the impact of BMP signaling in mesoderm formation, vasculogenesis, arteriovenous differentiation, sprouting angiogenesis, endothelial-to-mesenchymal transition (EndMT), and the barrier function of the endothelium.
Aberrant signaling during vascular morphogenesis as well as morphogenic processes, such as endothelial-to-mesenchymal transition (EndMT), have been implicated in several pathological conditions, including tumor neovascularization, hereditary hemorrhagic telangiectasia (HHT), cerebral cavernous malformation (CCM), and fibrodysplasia ossificans progressiva (FOP). We emphasize the molecular mechanisms underlying BMP-dependent regulations of endothelial cell functions and highlight possible applications in the treatment of vascular diseases.
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We would like to acknowledge funding from the BMBF (PrevOP/OVERLOAD) to PK. AB was supported by a fellowship from the Berlin School of Integrative Oncology (DFG graduate school 1093), and SH by a fellowship from the SFB958.
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Benn, A., Haupt, J., Hildebrandt, S., Kaehler, C., Knaus, P. (2017). Physiological and Pathological Consequences of Vascular BMP Signaling. In: Vukicevic, S., Sampath, K. (eds) Bone Morphogenetic Proteins: Systems Biology Regulators. Progress in Inflammation Research. Springer, Cham. https://doi.org/10.1007/978-3-319-47507-3_17
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