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Platelets in Thrombotic and Non-Thrombotic Disorders pp 531–539Cite as

The Role of Platelets During Development and Reproduction

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Abstract

Platelets are an essential component of the hemostatic system in non-pregnant and more so in pregnant women. Low platelet counts during pregnancy can be harmful both to the mother and the fetus and can lead to several complications during and after pregnancy. Studies in mice have demonstrated that platelets conduct important functions that ultimately contribute to normal development of the embryo and successful outcome of the pregnancy. While embryonic platelets are dispensable during intrauterine development, they are strictly required during the neonatal period to control hemostasis and closure of the ductus arteriosus. Conversely, maternal platelets—in addition to hemostasis—also regulate placental function, potentially through platelet-released mediators, and studies in mice suggest that increased platelet activation contributes towards the pathogenesis of hypertensive disorders of pregnancy (HDP). Maternal platelet activation has important but poorly defined functions at the feto-maternal vascular bed. This is exemplified by the crucial role of platelets for placental and developmental failure due to defects in the TM-EPCR coagulation system. The relevance of increased platelet activation for HDP is supported by the beneficial effects of inhibition of platelet activation on pregnancy outcome in women with HDP, as shown in large meta-analyses. However, there remains limited and meager mechanistic information on platelet associated pregnancy disorders, which coupled with the challenges of conducting clinical trials in pregnant women is restricting the development of novel therapeutics targeting platelet dependent patho-mechanisms during pregnancy.

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  1. Institute of Clinical Chemistry and Pathobiochemistry, Otto-von-Guericke-University Magdeburg, Leipziger Str. 44, 39120, Magdeburg, Germany

    Shrey Kohli & Berend Isermann

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  1. Shrey Kohli
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  2. Berend Isermann
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Correspondence to Berend Isermann .

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Editors and Affiliations

  1. Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia , Perugia, Italy

    Paolo Gresele

  2. Houston Methodist Hospital , Houston, Texas, USA

    Neal S. Kleiman

  3. Bloodworks Northwest, University of Washington , Seattle, Washington, USA

    José A. Lopez

  4. Sackler Inst of Pulmonary Pharmacol, King’s College London, London, United Kingdom

    Clive P. Page

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Kohli, S., Isermann, B. (2017). The Role of Platelets During Development and Reproduction. In: Gresele, P., Kleiman, N., Lopez, J., Page, C. (eds) Platelets in Thrombotic and Non-Thrombotic Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-47462-5_36

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