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Platelet Signaling: Protein Phosphorylation

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Platelets in Thrombotic and Non-Thrombotic Disorders

Abstract

Protein phosphorylation is the main mechanism by which platelet functional responses are regulated. There are myriad protein kinases in the platelet, which are classified by the residue in which they phosphorylate. Protein tyrosine kinases phosphorylate tyrosine residues, while protein serine/threonine kinases phosphorylate serine or threonine residues. Several important signaling cascades are initiated upon platelet activation. Here we will explore the relevance of phosphorylation of specific proteins important to several essential signaling cascades in platelets.

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Acknowledgements

This work is supported by HL93231 and HL118593 from National Institutes of Health to SPK and a postdoctoral Fellowship from the American Heart Association to JCK.

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Authors and Affiliations

  1. Department of Physiology and the Sol Sherry Thrombosis Research Center, Lewis Katz School of Medicine, Temple University, Rm. 403 MRB, 3420 N. Broad Street, Philadelphia, PA, 19140, USA

    Satya P. Kunapuli Ph.D., Dheeraj Bhavanasi, John C. Kostyak & Bhanu Kanth Manne

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  1. Satya P. Kunapuli Ph.D.
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  2. Dheeraj Bhavanasi
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  3. John C. Kostyak
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  4. Bhanu Kanth Manne
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Correspondence to Satya P. Kunapuli Ph.D. .

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Editors and Affiliations

  1. Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia , Perugia, Italy

    Paolo Gresele

  2. Houston Methodist Hospital , Houston, Texas, USA

    Neal S. Kleiman

  3. Bloodworks Northwest, University of Washington , Seattle, Washington, USA

    José A. Lopez

  4. Sackler Inst of Pulmonary Pharmacol, King’s College London, London, United Kingdom

    Clive P. Page

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Kunapuli, S.P., Bhavanasi, D., Kostyak, J.C., Manne, B.K. (2017). Platelet Signaling: Protein Phosphorylation. In: Gresele, P., Kleiman, N., Lopez, J., Page, C. (eds) Platelets in Thrombotic and Non-Thrombotic Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-47462-5_22

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