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Implications of Platelet RNA to Vascular Health and Disease

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Platelets in Thrombotic and Non-Thrombotic Disorders

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Abstract

The historical relevance of platelets has focused on their traditional role in the circulation of hemostasis and thrombosis. Recent studies of platelet composition and novel platelet roles in a number of non-hemostatic systemic responses have since broadened our appreciation for the functional capabilities of platelets. One such expansion of our understanding includes the exploration of the platelet’s endogenous RNA and its ability to regulate platelet immune and inflammatory processes. RNA profiling of platelet messenger RNA (mRNA) and microRNA (miRNA) revealed distinct expression patterns associated with a number of platelet phenotypes and disease pathologies. A deeper understanding of the genetic material present in platelets endogenously and in disease settings can further elucidate the role platelet RNA plays in thrombosis and the implications of platelet involvement in fields such as cancer, infection, and systemic inflammation.

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Acknowledgments

The authors would like thank Olga Vitseva for preparing the platelet image and to acknowledge Hannah Hoffman and Hannah Iafrati for their assistance in the preparation of this chapter.

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Authors and Affiliations

  1. University of Massachusetts Medical School, 368 Plantation St., Worcester, MA, 01605-4319, USA

    Lauren Clancy & Jane E. Freedman M.D.

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  1. Lauren Clancy
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  2. Jane E. Freedman M.D.
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Correspondence to Jane E. Freedman M.D. .

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Editors and Affiliations

  1. Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia , Perugia, Italy

    Paolo Gresele

  2. Houston Methodist Hospital , Houston, Texas, USA

    Neal S. Kleiman

  3. Bloodworks Northwest, University of Washington , Seattle, Washington, USA

    José A. Lopez

  4. Sackler Inst of Pulmonary Pharmacol, King’s College London, London, United Kingdom

    Clive P. Page

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Clancy, L., Freedman, J.E. (2017). Implications of Platelet RNA to Vascular Health and Disease. In: Gresele, P., Kleiman, N., Lopez, J., Page, C. (eds) Platelets in Thrombotic and Non-Thrombotic Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-47462-5_19

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