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The Platelet Transcriptome: Coding RNAs

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Platelets in Thrombotic and Non-Thrombotic Disorders

Abstract

Until recently platelets were categorized as simple anucleate cytoplasts that function solely in the hemostatic arena. However, the last decade has demonstrated that platelets have roles beyond primary hemostasis and they possess complex molecular information including a rich repertoire of messenger RNAs (mRNAs). Platelet mRNAs have features that mirror transcripts produced and translated in nucleated cells, and mRNAs for approximately half of the human genome have been identified in this terminally differentiated cell. The study of platelet mRNAs has expanded tremendously with the advent of next-generation RNA sequencing (NGS) and several groups have shown that platelets are capable of translating some megakaryocyte-derived mRNAs into protein. Platelet mRNA profiles have also been used to predict cellular function and platelets are capable of transferring intact mRNAs into microparticles and other cells. This chapter reviews our current understanding of platelet mRNAs and their potential contribution to biological and pathologic processes in humans. Roles for noncoding RNAs are described in Edelstein and Bray (2017).

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Authors and Affiliations

  1. Molecular Medicine Program and Department of Internal Medicine, Eccles Institute of Human Genetics, University of Utah, Bldg 533, Rm 4220, Salt Lake City, UT, 84112, USA

    Jesse W. Rowley, Bhanu Kanth Manne & Andrew S. Weyrich

Authors
  1. Jesse W. Rowley
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  2. Bhanu Kanth Manne
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  3. Andrew S. Weyrich
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Corresponding authors

Correspondence to Jesse W. Rowley or Andrew S. Weyrich .

Editor information

Editors and Affiliations

  1. Department of Medicine, Section of Internal and Cardiovascular Medicine, University of Perugia , Perugia, Italy

    Paolo Gresele

  2. Houston Methodist Hospital , Houston, Texas, USA

    Neal S. Kleiman

  3. Bloodworks Northwest, University of Washington , Seattle, Washington, USA

    José A. Lopez

  4. Sackler Inst of Pulmonary Pharmacol, King’s College London, London, United Kingdom

    Clive P. Page

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Rowley, J.W., Manne, B.K., Weyrich, A.S. (2017). The Platelet Transcriptome: Coding RNAs. In: Gresele, P., Kleiman, N., Lopez, J., Page, C. (eds) Platelets in Thrombotic and Non-Thrombotic Disorders. Springer, Cham. https://doi.org/10.1007/978-3-319-47462-5_17

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