Abstract
Duck Tembusu virus (TMUV) is a newly emergent pathogen belonging to the Ntaya virus group in the genus Flavivirus. The clinical disease caused by TMUV infection has been recognized in ducks since 2010 and is characterized by severe egg drop and neurological manifestations. The infection is now endemic to Mainland China and affects domestic ducks, geese, and occasionally laying hens. A large amount of research has been directed toward this virus in recent years. In this chapter, we review the progress made in recent years in understanding the pathobiology of the virus, its diagnosis, and vaccine development.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Bai X, Shao Z, Zhang Q et al (2015) Characterization of monoclonal antibodies against duck Tembusu virus E protein: an antigen-capture ELISA for the detection of Tembusu virus infection. Arch Virol 160(3):757–764. doi:10.1007/s00705-014–2312–z
Cao Z, Zhang C, Liu Y et al (2011) Tembusu virus in ducks, china. Emerg Infect Dis 17(10):1873–1875. doi:10.3201/eid1710.101890
Capua I, Mutinelli F (2001) Mortality in Muscovy ducks (Cairinamoschata) and domestic geese (Anseranser var. domestica) associated with natural infection with a highly pathogenic avian influenza virus of H7N1 subtype. Avian Pathol 30(2):179–183. doi:10.1080/03079450120044597
Chancey C, Grinev A, Volkova E et al (2015) The global ecology and epidemiology of West Nile virus. Biomed Res Int 2015:376230. doi:10.1155/2015/376230
Chen H, Liu X, Tang Y et al (2013) Complete genome sequences of two waterfowl-origin tembusu virus strains isolated in shandong province, china. Genome Announc 1(6) pii: e00789–e00713. doi:10.1128/genomeA.00789–13
Chen H, Ou Q, Tang Y et al (2014a) Development and evaluation of a DAS-ELISA for rapid detection of Tembusu virus using monoclonal antibodies against the envelope protein. PLoS One 9(5):e96366. doi:10.1371/journal.pone.0096366
Chen S, Wang S, Li Z et al (2014b) Isolation and characterization of a Chinese strain of Tembusu virus from Hy-Line Brown layers with acute egg-drop syndrome in Fujian, China. Arch Virol 159(5):1099–1107. doi:10.1007/s00705-013-1931–0
Fernández-Pinero J, Davidson I, Elizalde M et al (2014) Bagaza virus and Israel turkey meningoencephalomyelitis virus are a single virus species. J Gen Virol 95(Pt 4):883–7. doi:10.1099/vir.0.061465–0
Food and Agriculture Organization of the United Nations (2013) The FAO register. http://faostat3.fao.org/browse/Q/QA/E
Fu Y, Ji Y, Liu B et al (2015) Development of a solid-phase competition ELISA to detect antibodies against newly emerged Duck Tembusu virus. J Virol Methods 224:73–76. doi:10.1016/j.jviromet.2015.08.017
Grubaugh ND, McMenamy SS, Turell MJ et al (2013) Multi-gene detection and identification of mosquito-borne RNA viruses using an oligonucleotide microarray. PLoS Negl Trop Dis 7(8):e2349. doi:10.1371/journal.pntd.0002349 eCollection 2013
Homonnay ZG, Kovács EW, Bányai K et al (2014) Tembusu-like flavivirus (Perak virus) as the cause of neurological disease outbreaks in young Pekin ducks. Avian Pathol 43(6):552–560. doi:10.1080/03079457.2014.973832
Huang X, Han K, Zhao D et al (2013) Identification and molecular characterization of a novel flavivirus isolated from geese in China. Res Vet Sci 94(3):774–780
Jiang T, Liu J, Deng YQ et al (2012) Development of RT-LAMP and real-time RT-PCR assays for the rapid detection of the new duck Tembusu–like BYD virus. Arch Virol 157(12):2273–2280. doi:10.1007/s00705-012–1431–7
Kono Y, Tsukamoto K, Hamid M et al (2000) Encephalitis and retarded growth of chicks caused by sitiawan virus, a new isolate belonging to the genus flavivirus. Am J Trop Med Hyg 63(1, 2):94–101
Li L, An H, Sun M et al (2012a) Identification and genomic analysis of two duck-origin Tembusu virus strains in southern China. Virus Genes 45(1):105–112. doi:10.1007/s11262-012-0753-6
Li X, Li G, Teng Q et al (2012b) Development of a blocking ELISA for detection of serum neutralizing antibodies against newly emerged duck Tembusu virus. PLoS One 7(12):e53026. doi:10.1371/journal.pone.0053026
Li S, Li X, Zhang L et al (2013) Duck Tembusu virus exhibits neurovirulence in BALB/c mice. Virol J 10:260. doi:10.1186/1743–422X-10-260
Li G, Gao X, Xiao Y et al (2014) Development of a live attenuated vaccine candidate against duck Tembusu viral disease. Virology 450-451:233–242. doi:10.1016/j.virol.2013.12.028
Li X, Shi Y, Liu Q et al (2015) Airborne Transmission of a Novel Tembusu Virus in Ducks. J Clin Microbiol 53(8):2734–2736. doi:10.1128/JCM.00770–15
Liu M, Chen S, Chen Y et al (2012a) Adapted Tembusu-like virus in chickens and geese in China. J Clin Microbiol 50(8):2807–2809. doi:10.1128/JCM.00655–12
Liu P, Lu H, Li S et al (2012b) Genomic and antigenic characterization of the newly emerging Chinese duck egg-drop syndrome flavivirus: genomic comparison with Tembusu and Sitiawan viruses. J Gen Virol 93(Pt 10):2158–2170. doi:10.1099/vir.0.043554–0
Liu Z, Fu Y, Ji Y et al (2013) Development and validation of one-step SYBR green real-time RT-PCR for the rapid detection of newly emerged duck Tembusu virus. Avian Dis 57(3):595–601
Mackenzie JS, Williams DT (2009) The zoonotic flaviviruses of southern, south-eastern and eastern Asia, and Australasia: the potential for emergent viruses. Zoonoses Public Health 56:338–356
O’Guinn ML, Turell MJ, Kengluecha A et al (2013) Field detection of Tembusu virus in western Thailand by rt–PCR and vector competence determination of select culex mosquitoes for transmission of the virus. Am J Trop Med Hyg 89(5):1023–1028. doi:10.4269/ajtmh.13–0160
Pandey BD, Karabatsos N, Cropp B et al (1999) Identification of a flavivirus isolated from mosquitos in Chiang Mai Thailand. Southeast Asian J Trop Med Public Health 30(1):161–165
Pantin-Jackwood MJ, Suarez DL, Spackman E et al (2007) Age at infection affects the pathogenicity of Asian highly pathogenic avian influenza H5N1 viruses in ducks. Virus Res 130(1–2):151–161
Perkins LE, Swayne DE (2002) Pathogenicity of a Hong Kong-origin H5N1 highly pathogenic avian influenza virus for emus, geese, ducks, and pigeons. Avian Dis 46(1):53–63
Petz LN, Turell MJ, Padilla S et al (2014) Development of conventional and real-time reverse transcription polymerase chain reaction assays to detect Tembusu virus in Culextarsalis mosquitoes. Am J Trop Med Hyg 91(4):666–671. doi:10.4269/ajtmh.13–0218
Shirafuji H, Kanehira K, Kubo M et al (2009) Experimental West Nile virus infection in aigamo ducks, a cross between wild ducks (Anasplatyrhynchos) and domestic ducks (Anasplatyrhynchos var. domesticus). Avian Dis 53:239–244
Su J, Li S, Hu X et al (2011) Duck egg-drop syndrome caused by BYD virus, a new Tembusu-related flavivirus. PLoS One 6(3):e18106. doi:10.1371/journal.pone.0018106
Sudeep AB (2014) Culexgelidus: an emerging mosquito vector with potential to transmit multiple virus infections. J Vector Borne Dis 51(4):251–258
Sun L, Li Y, Zhang Y et al (2014a) Adaptation and attenuation of duck Tembusu virus strain Du/CH/LSD/110128 following serial passage in chicken embryos. Clin Vaccine Immuno 21(8): 1046–53. doi:10.1128/CVI.00154–14
Sun S, Chen F, Cao S et al (2014a) Isolation and characterization of a subtype C avian metapneumovirus circulating in Muscovy ducks in China. Vet Res 45:74. doi:10.1186/s13567–014-0074–y
Swayne DE, Suarez DL, Sims LD (2013) Influenza. In Swayne DE (ed) Disease of poultry, 13th edn. Wiley, New Jersey, pp 181–218
Tang Y, Diao Y, Yu C et al (2012) Rapid detection of Tembusu virus by reverse-transcription, loop-mediated isothermal amplification (RT-LAMP). Transbound Emerg Dis 59(3):208–213. doi:10.1111/j.1865–1682.2011.01257
Tang Y, Diao Y, Yu C et al (2013) Characterization of a Tembusu virus isolated from naturally infected house sparrows (Passer domesticus) in Northern China. Transbound Emerg Dis 60(2):152–158. doi:10.1111/j.1865–1682.2012.01328
Tomohiro I, Atsushi Y, Eiji K (2014) A review of successful flavivirus vaccines and the problems with those flaviviruses for which vaccines are not yet available. Vaccine 32:1326–1337
Vaidya NK, Wang FB, Zou X et al (2012) Transmission dynamics of the recently-identified BYD virus causing duck egg-drop syndrome. PLoS One 7(4):e35161. doi:10.1371/journal.pone.0035161
Wan C, Huang Y, Fu G et al (2012) Complete genome sequence of avian tembusu-related virus strain WR isolated from White Kaiya ducks in Fujian, China. J Virol 86(19):10912. doi:10.1128/JVI.01582–12
Wang Y, Yuan X, Li Y et al (2011) Rapid detection of newly isolated Tembusu-related Flavivirus by reverse-transcription loop-mediated isothermal amplification assay. Virol J 8:553. doi:10.1186/1743–422X–8–553
Wolfe ND, Kilbourn AM, Karesh WB et al (2001) Sylvatic transmission of arboviruses among Bornean orangutans. Am J Trop Med Hyg 64(5–6):310–316
Wu L, Liu J, Chen P et al (2014) The sequential tissue distribution of duck Tembusu virus in adult ducks. Biomed Res Int 2014:703930. doi:10.1155/2014/703930
Yan L, Yan P, Zhou J et al (2011a) Establishing a TaqMan-based real-time PCR assay for the rapid detection and quantification of the newly emerged duck Tembusu virus. Virol J 8:464. doi:10.1186/1743–422X–8–464
Yan P, Zhao Y, Zhang X et al (2011b) An infectious disease of ducks caused by a newly emerged Tembusu virus strain in mainland China. Virology 417(1):1–8. doi:10.1016/j.virol.2011.06.003
Yan L, Peng S, Yan P et al (2012) Comparison of real-time reverse transcription loop-mediated isothermal amplification and real-time reverse transcription polymerase chain reaction for duck Tembusu virus. J Virol Methods 182(1–2):50–55
Yin X, Lv R, Chen X et al (2013) Detection of specific antibodies against tembusu virus in ducks by use of an E protein-based enzyme-linked immunosorbent assay. J Clin Microbiol 51(7):2400–2402. doi:10.1128/JCM.00361–13
Yu K, Sheng ZZ, Huang B et al (2013) Structural, antigenic, and evolutionary characterizations of the envelope protein of newly emerging Duck Tembusu Virus. PLoS One 8(8):e71319. doi:10.1371/journal.pone.0071319
Yun T, Ni Z, Hua J et al (2012a) Development of a one-step real-time RT-PCR assay using a minor-groove-binding probe for the detection of duck Tembusu virus. J Virol Methods 181(2):148–154. doi:10.1016/j.jviromet.2012.01.019
Yun T, Ye W, Ni Z et al (2012b) Identification and molecular characterization of a novel flavivirus isolated from Pekin ducklings in China. Vet Microbiol 157(3–4):311–319. doi:10.1016/j.vetmic.2012.01.013
Zeng T, Xie Z, Xie L et al (2015) Identification and whole-genome sequence analysis of Tembusu Virus GX2013G, isolated from a Cherry Valley Duckling in Southern China. Genome Announc 3(1) pii: e00007–e00015. doi:10.1128/genomeA.00007-15
Zhang Y, Li X, Chen H et al (2015) Evidence of possible vertical transmission of Tembusu virus in ducks. Vet Microbiol 179(3–4):149–154. doi:10.1016/j.vetmic.2015.06.004
Zhu W, Chen J, Wei C et al (2012) Complete genome sequence of duck Tembusu virus, isolated from Muscovy ducks in southern China. J Virol 86(23):13119. doi:10.1128/JVI.02361–12
Zhu K, Huang J, Jia R et al (2015) Identification and molecular characterization of a novel duck Tembusu virus isolate from Southwest China. Arch Virol 160(11):2781–2790. doi:10.1007/s00705–015–2513–0
Zou Z, Liu Z, Jin M (2014) Efficient strategy to generate a vectored duck enteritis virus delivering envelope of duck Tembusu virus. Viruses 6(6):2428–43. doi:10.3390/v6062428
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2017 Springer International Publishing AG
About this chapter
Cite this chapter
Zhang, L., Su, J. (2017). Duck Tembusu Virus Infection. In: Bayry, J. (eds) Emerging and Re-emerging Infectious Diseases of Livestock. Springer, Cham. https://doi.org/10.1007/978-3-319-47426-7_9
Download citation
DOI: https://doi.org/10.1007/978-3-319-47426-7_9
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-319-47424-3
Online ISBN: 978-3-319-47426-7
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)