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Immunopathology in Toxicology and Drug Development pp 649–694Cite as

Immunopathology of the Endocrine System

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Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

Abstract

It is well recognized that there is important cross-communication and inter-regulation that occurs between the endocrine, immune, and nervous systems during development and adult life. This chapter will specifically focus on interactions between the immune and endocrine systems related to (1) autoimmune diseases of the endocrine glands due to disruption of tolerance and development of adaptive immunity, (2) the effects of drugs and chemicals on induction of endocrine autoimmune diseases, (3) the newly recognized role of innate immunity in endocrine disorders, such as diabetes mellitus and obesity, (4) the effects of cytokines from immune cells on endocrine cells, and (5) effects of select hormones, such as glucocorticoids, prolactin, and parathyroid hormone on the immune system.

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  1. Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, 43210, USA

    Thomas J. Rosol

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    Brent E. Walling

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    George A. Parker

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Rosol, T.J., Walling, B.E. (2017). Immunopathology of the Endocrine System. In: Parker, G. (eds) Immunopathology in Toxicology and Drug Development. Molecular and Integrative Toxicology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-47385-7_13

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