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Clinical Pathology Assays in Immunopathology

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Immunopathology in Toxicology and Drug Development

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

Abstract

Clinical pathology endpoints are evaluated during the course of toxicity studies to monitor structural and functional changes in organs and tissues in response to administration or withdrawal of a test item. A variety of assays can be performed in a clinical pathology laboratory with body fluids using either clinical pathology analyzers or other instruments. Information from the basic assays in clinical pathology, including hematology, clinical chemistry, urinalysis and coagulation are used with other safety assessment endpoints to evaluate immunotoxicity. Non-routine clinical pathology variables, such as acute phase proteins, cytokines, complement, hormones, autoantibodies, and bone marrow cytology are also included in preclinical toxicity studies as supplementary assays to ensure adequate interpretation of test item-related effects on the immune system. This chapter will describe the clinical pathology assays that are most useful to assess immunotoxicity.

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Authors and Affiliations

  1. Charles River Laboratories, Inc., 1407 George Road, Ashland, OH, 44808, USA

    Josely F. Figueiredo

  2. AbbVie, 1 North Waukegan Road, North Chicago, IL, 60064, USA

    Kirstin F. Barnhart

  3. Covance Laboratories, 3301 Kinsman Blvd, Madison, WI, 53704, USA

    Niraj Tripathi

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  1. Josely F. Figueiredo
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  2. Kirstin F. Barnhart
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  3. Niraj Tripathi
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Correspondence to Josely F. Figueiredo .

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  1. Charles River Laboratories, Inc. , Hillsborough, North Carolina, USA

    George A. Parker

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Figueiredo, J.F., Barnhart, K.F., Tripathi, N. (2017). Clinical Pathology Assays in Immunopathology. In: Parker, G. (eds) Immunopathology in Toxicology and Drug Development. Molecular and Integrative Toxicology. Humana Press, Cham. https://doi.org/10.1007/978-3-319-47377-2_9

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