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Signaling and Effector Molecules in Immunity

  • Michael C. Milone
Chapter
Part of the Molecular and Integrative Toxicology book series (MOLECUL)

Abstract

Initiation of an innate and/or adaptive immune response involves the coordinated function of multiple cells as well as numerous signaling and effector molecules, all supported by a stromal framework that may provide additional immunomodulatory signals. Signaling and effector molecules of the immune system have been the focus of intense investigation in recent decades, resulting in a massive accumulation of relevant information. The aim of this chapter is to provide an overview of the major groups of signaling and effector molecules, and to provide a general framework whereby these molecules function in the initiation, modulation, and dissolution of immune responses. Particular interest is given to those molecules and processes that represent targets for possible pharmacological intervention.

Keywords

Cytokine Chemokine Interferon Tumor necrosis factor (TNF) IL-1 T cell receptor (TCR) B cell receptor (BCR) Antibody Fc receptor Complement 

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© Springer International Publishing AG 2017

Authors and Affiliations

  1. 1.Toxicology and Therapeutic Drug Monitoring LaboratoryHospital of the University of PennsylvaniaPhiladelphiaUSA

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