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Cancer, Alcohol, and Aging

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Alcohol and Aging

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Abstract

Since 1988, alcohol has been classified as a carcinogen and has been attributed to almost seven million deaths per year, the majority of which occur in those 65 years of age and older. Adults 65 years of age or older with a history of at-risk alcohol use over their life time, particularly those with a history of tobacco use, should be routinely screened for alcohol-related cancers. Understanding the relationship between the metabolism of alcohol and cancer is essential knowledge for health care providers who care for older adults. In addition, applying appropriate interventions for older adults experiencing alcohol-associated cancers can assist with decreased alcohol use and pain management.

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References

  1. Cancer prevention and control [Internet]. World Health Organization [cited 2015 Aug 21]. http://www.who.int/nmh/a5816/en/

  2. Cancer prevention [Internet]. World Health Organization [cited 2015 Aug 21]. http://www.who.int/cancer/prevention/en/

  3. Schütze M, Boeing H, Pischon T, et al. Alcohol attributable burden of incidence of cancer in eight European countries based on results from prospective cohort study. BMJ. 2011;342:d1584.

    Article  PubMed  PubMed Central  Google Scholar 

  4. Boffetta P, Hashibe M, La Vecchia C, Zatonski W, Rehm J. The burden of cancer attributable to alcohol drinking. Int J Cancer. 2006;119(4):884–7.

    Article  CAS  PubMed  Google Scholar 

  5. Nelson DE, Jarman DW, Rehm J, Greenfield TK, Rey G, Kerr WC. Alcohol-attributable cancer deaths and years of potential life lost in the United States. Am J Public Health. 2013;103(4):641–8.

    Article  PubMed  PubMed Central  Google Scholar 

  6. International Agency for Research on Cancer Working Group. IARC monographs on the evaluation of the carcinogenic risks to humans: alcohol drinking [Internet]. Lyon: IARC; 1988 [cited 2015 Aug 21]. http://monographs.iarc.fr/ENG/Monographs/vol44/mono44.pdf.

  7. Eriksson CP. Genetic–epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking. In: Vasiliou V, Zakhari S, Seitz H, Hoek JB, editors. Biological basis of alcohol-induced cancer. New York: Springer International Publishing; 2015.

    Google Scholar 

  8. Cancer Stat Fact Sheets [Internet]. National Cancer Institute [cited 2015 Aug 21]. http://seer.cancer.gov/statfacts/

  9. Seitz HK, Mueller S. Alcohol and cancer: an overview with special emphasis on the role of acetaldehyde and cytochrome P450 2E1. In: Vasiliou V, Zakhari S, Seitz H, Hoek JB, editors. Biological basis of alcohol-induced cancer. New York: Springer International Publishing; 2015.

    Google Scholar 

  10. Seitz HK, Becker P. Alcohol metabolism and cancer risk. Alc Res Health. 2007;30(1):38–47.

    Google Scholar 

  11. Kumagai N, Wakai T, Akazawa K, et al. Heavy alcohol intake is a risk factor for esophageal squamous cell carcinoma among middle aged men: a case-control and simulation study. Mol Clin Oncol. 2013;1(5):811–6.

    PubMed  PubMed Central  Google Scholar 

  12. Malhotra J, Praud D, Boffetta P. Changes in trends of alcohol-related cancers: perspectives on statistical trends. Chem Res Toxicol. 2015;28(9):1661–5. doi:10.1021/acs.chemrestox.5b00187.

    Article  CAS  PubMed  Google Scholar 

  13. Alcohol and cancer risk [Internet]. National Cancer Institute [cited 2015 Aug 21]. http://www.cancer.gov/about-cancer/causes-prevention/risk/alcohol/alcohol-fact-sheet.

  14. What are the risk factors for breast cancer? [Internet]. American Cancer Society [cited 2015 Aug 21]. http://www.cancer.org/cancer/breastcancer/detailedguide/breast-cancer-risk-factors.

  15. Helping patients who drink too much: a clinician's guide [Internet]. Bethesda: National Institute on Alcohol Abuse and Alcoholism. 2007 [cited 2015 Aug 21]. http://pubs.niaaa.nih.gov/publications/Practitioner/CliniciansGuide2005/clinicians_guide.htm

  16. Bergmann MM, Rehm J, Klipstein-Grobusch K, et al. The association of pattern of lifetime alcohol use and cause of death in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Int J Epidemiol. 2013;42:1772–90. doi:10.1093/ije/dyt154.

    Article  PubMed  Google Scholar 

  17. Bagnardi V, Blangiardo M, LaVecchia C, Corrao G. A meta-analysis of alcohol drinking and cancer risk. Br J Cancer. 2001;85(11):1700–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Cao Y, Willet WC, Rimm EB, Stampler MJ, Giovannucci EL. Light to moderate intake of alcohol, drinking patterns, and risk of cancer: results from two perspective US cohort studies. BMJ. 2015;351:h4238.

    Article  PubMed  PubMed Central  Google Scholar 

  19. Talamini R, Bosetti C, La Vecchia C, et al. Combined effect of tobacco and alcohol on laryngeal cancer risk: a case-control study. Cancer Causes Control. 2002;13(1):957–64.

    Article  CAS  PubMed  Google Scholar 

  20. Homann N, Tillonen J, Rintamäki H, Salaspuro M, Lindqvist C, Meurman JH. Poor dental status increases acetaldehyde production from ethanol in saliva: a possible link to increased oral cancer risk among heavy drinkers. Oral Oncol. 2001;37(2):153–8.

    Article  CAS  PubMed  Google Scholar 

  21. Waszkiewicz N, Jelski W, Zalewska A, et al. Salivary alcohol dehydrogenase in non-smoking and smoking alcohol-dependent persons. Alcohol. 2014;48(6):611–6.

    Article  CAS  PubMed  Google Scholar 

  22. Rettig EM, D’Souza G. Epidemiology of head and neck cancer. Surg Oncol Clin N Am. 2015;24(3):379–96.

    Article  PubMed  Google Scholar 

  23. Leon ME, Peruga A, McNeill A, Kralikova E, Guha N, Minozzi S. European code against cancer: tobacco and cancer. Cancer Epidemiol. 2015;39 Suppl 1:S20–33. http://dx.doi.org/10.1016/j.canep.2015.06.001.

    Article  PubMed  Google Scholar 

  24. Hashibe M, Brenna P, Benhamou S, et al. Alcohol drinking in never users of tobacco, cigarette smoking in never drinkers and the risk of health and neck cancer: pooled analysis in the international head and neck cancer epidemiology consortium. J Natl Cancer Inst Monogr. 2007;99(10):777–89.

    Article  Google Scholar 

  25. Chuang SC, Lee YA, Wu GJ, Straif K, Hashibe M. Alcohol consumption and liver cancer risk: a meta-analysis. Cancer Causes Control. 2015;26(9):1205–31.

    Article  PubMed  Google Scholar 

  26. Rahman F, Cotterchio M, Cleary SP, Gallinger S. Association between alcohol consumption and pancreatic cancer risk: a case-control study. 2015. PLoS One. 2015;10(4), e0124489. doi:10.1371/journal.pone.0124489.

    Article  PubMed  PubMed Central  Google Scholar 

  27. Frederiko V, Tramacere I, Bagnardi V, et al. Alcohol drinking and colorectal cancer risk: an overall and dose-response meta-analysis of published studies. Ann Oncol. 2011;22(9):1958–72.

    Article  Google Scholar 

  28. Hurley TD, Edenberg HJ. Genes encoding enzymes involved in ethanol metabolism. Alcohol Res. 2012;34(3):339–44.

    PubMed  PubMed Central  Google Scholar 

  29. International Agency for Research on Cancer. Personal habits and indoor combustions [Internet]. Lyon: IARC; 2012 [cited 2015 Aug 21]. http://monographs.iarc.fr/ENG/Monographs/vol100E/mono100E.pdf.

  30. Ribezzo F, Shiloh Y, Schumacher B. Systemic DNA damage responses in aging and diseases. Semin Cancer Biol. 2016;37–38:26–35. doi:10.1016/j.semcancer.2015.12.005.

    Article  PubMed  PubMed Central  Google Scholar 

  31. Scoccianti C, Cecchini M, Anderson AS, et al. European Code against Cancer 4th Edition: Alcohol drinking and cancer. Cancer Epidemiol. 2015;39:S67–74.

    Article  PubMed  Google Scholar 

  32. Oncology Nursing Society (2014). Cancer pain management. https://www.ons.org/advocacy-policy/positions/practice/pain-management.

  33. National Cancer Institute, Alcohol [Internet]. 2015 [cited 2016 March 7]. http://www.cancer.gov/about-cancer/causes-prevention/risk/alcohol.

  34. Bradley KKA, DeBenedetti AF, Volk RJ, Williams EC, Frank D, Kivlahan DR. AUDIT-C as a brief screen for alcohol misuse in primary care. Alcohol Clin Exp Res. 2007;31(7):1208–17.

    Article  PubMed  Google Scholar 

  35. National Institutes of Health. Alcohol Alert No. 27. PH355 Jan 1995.

    Google Scholar 

  36. Cousins G, Galvin R, Flood M, et al. Potential for alcohol and drug interactions in older adults: evidence from the Irish longitudinal study on ageing. BMC Geriatr. 2014;14:57.

    Article  PubMed  PubMed Central  Google Scholar 

  37. Paull DE, Updyke GM, Baumann MA, Chin HW, Little AG, Adebonojo SA. Alcohol abuse predicts progression of disease and death in patients with lung cancer. Ann Thorac Surg. 2005;80(3):1033–9.

    Article  PubMed  Google Scholar 

  38. Chang C-C, Kao H-K, Huang J-J, Tsao C-K, Cheng M-H, Wei F-C. Postoperative alcohol withdrawal syndrome and neuropsychological disorder in patients after head and neck cancer ablation followed by microsurgical free tissue transfer. J Reconstr Microsurg. 2013;29(2):131–6.

    Article  PubMed  Google Scholar 

  39. Genther DJ, Gourin CG. The effect of alcohol abuse and alcohol withdrawal on short-term outcomes and cost of care after head and neck cancer surgery. Laryngoscope. 2012;122(8):1739–47.

    Article  PubMed  Google Scholar 

  40. Neuenschwander AU, Pedersen JH, Krasnik M, Tønnesen H. Impaired postoperative outcome in chronic alcohol abusers after curative resection for lung cancer. Eur J Cardiothorac Surg. 2002;22(2):287–91.

    Article  CAS  PubMed  Google Scholar 

  41. Wu I-C, Wu C-C, Lu C-Y, et al. Substance use (alcohol, areca nut and cigarette) is associated with poor prognosis of esophageal squamous cell carcinoma. PLoS One. 2013;8(2), e55834.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  42. Neyman KM, Gourin CG, Terris DJ. Alcohol withdrawal prophylaxis in patients undergoing surgical treatment of head and neck squamous cell carcinoma. Laryngoscope. 2005;115(5):786–90.

    Article  PubMed  Google Scholar 

  43. Paull DE, Updyke GM, Davis CA, Adebonojo SA. Complications and long-term survival for alcoholic patients with resectable lung cancer. Am J Surg. 2004;188(5):553–9.

    Article  PubMed  Google Scholar 

  44. Paice J, Ferrell B. The management of cancer pain. CA Cancer J Clin. 2011;61:157–82.

    Article  PubMed  Google Scholar 

  45. Aranda S, Yates P, Edwards H, Nash R, Skerman H, McCarthy A. Barriers to effective cancer pain management: a survey of Australian family caregivers. Eur J Cancer Care. 2004;13(4):336–43.

    Article  CAS  Google Scholar 

  46. Baney T, Belansksy H, Gutaj D, et al. Red flags in caring for cancer survivors [Internet]. Oncology Nursing Society. 2014 [cited 2015 Aug 21]. https://www.ons.org/sites/default/files/media/Red%20Flags%20for%20Cancer%20Survivors.pdf.

  47. Cohen E, Botti M, Hanna B, Leach S, Boyd S, Robbins J. Pain beliefs and pain management of oncology patients. Cancer Nurs. 2008;31(2):E1–8.

    Article  PubMed  Google Scholar 

  48. Morasco BJ, Turk DC, Donovan DM, Dobscha SK. Risk for prescription opioid misuse among patients with a history of substance use disorder. Drug Alcohol Depend. 2013;127(1-3):193–9.

    Article  PubMed  Google Scholar 

  49. Kwon JH, Hui D, Chisholm G, Bruera E. Predictors of long-term opioid treatment among patients who receive chemoradiation for head and neck cancer. Oncologist. 2013;18(6):768–74.

    Article  PubMed  PubMed Central  Google Scholar 

  50. Breslow RA, Chen CM, Graubard BI, Mukamal KJ. Prospective study of alcohol consumption quantity and frequency and cancer-specific mortality in the US population. Am J Epidemiol. 2011;174(9):1044–53.

    Article  PubMed  PubMed Central  Google Scholar 

  51. Jin M, Cai S, Guo J, et al. Alcohol drinking and all cancer mortality: a meta-analysis. Ann Oncol. 2013;24(3):807–16.

    Article  CAS  PubMed  Google Scholar 

  52. Farshadpour F. Survival analysis of head and neck squamous cell carcinoma: influence of smoking and drinking. Head Neck. 2011;33(6):817–23.

    Article  PubMed  Google Scholar 

  53. Mehanna HM, De Boer MF, Morton RP. The association of psycho-social factors and survival in head and neck cancer. Clin Otolaryngol. 2008;33(2):83–9.

    Article  CAS  PubMed  Google Scholar 

  54. Tannenbaum SL, Koru-Sengul T, Zhao W, Miao F, Byrne MM. Survival disparities in non-small cell lung cancer by race, ethnicity, and socioeconomic status. Cancer J. 2014;20(4):237–45.

    Article  PubMed  Google Scholar 

  55. Vrieling A, Buck K, Heinz J, et al. Pre-diagnostic alcohol consumption and postmenopausal breast cancer survival: a prospective patient cohort study. Breast Cancer Res Treat. 2012;136(1):195–207.

    Article  PubMed  Google Scholar 

  56. Druesne-Pecollo N, Keita Y, Touvier M, et al. Alcohol drinking and second primary cancer risk in patients with upper aerodigestive tract cancers: a systematic review and meta-analysis of observational studies. Cancer Epidemiol Biomarkers Prev. 2014;23(2):324–31.

    Article  PubMed  Google Scholar 

  57. Passik S, Theobald D. Managing addiction in advanced cancer patients: why bother? J Pain Symptom Mangage. 2000;19(3):229–34.

    Article  CAS  Google Scholar 

  58. Danker H, Keszte J, Singer S, et al. Alcohol consumption after laryngectomy. Clinical Otolaryngol. 2011;36(4):336–44.

    Article  CAS  Google Scholar 

  59. Parsons HA, Delgado-Guay MO, El Osta B, et al. Alcoholism screening in patients with advanced cancer: impact on symptom burden and opioid use. J Palliat Med. 2008;11(7):964–8.

    Article  PubMed  PubMed Central  Google Scholar 

  60. Potash AE, Karnell LH, Christensen AJ, Vander Weg MW, Funk GF. Continued alcohol use in patients with head and neck cancer. Head Neck. 2009;32(7):905–12.

    Google Scholar 

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Authors and Affiliations

  1. Department of Community-Public Health, Johns Hopkins University School of Nursing, Baltimore, MD, USA

    Christine L. Savage Ph.D., R.N., C.A.R.N., F.A.A.N. & Deborah S. Finnell D.N.S.

  2. Department of Radiation Oncology & Molecular Radiation Sciences, Johns Hopkins Hospital, Baltimore, MD, USA

    Amanda Choflet M.S., R.N., O.C.N.

Authors
  1. Christine L. Savage Ph.D., R.N., C.A.R.N., F.A.A.N.
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  2. Deborah S. Finnell D.N.S.
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  3. Amanda Choflet M.S., R.N., O.C.N.
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Corresponding author

Correspondence to Christine L. Savage Ph.D., R.N., C.A.R.N., F.A.A.N. .

Editor information

Editors and Affiliations

  1. Silberman School of Social Work, Hunter College at the City University of New York, New York, New York, USA

    Alexis Kuerbis

  2. Division of Geriatrics, University of California, San Diego, San Diego, California, USA

    Alison.A. Moore

  3. School of Social Work, University of Maryland, Baltimore, Maryland, USA

    Paul Sacco

  4. Department of Behavioral & Community Health, School of Public Health, University of Maryland, College Park, Maryland, USA

    Faika Zanjani

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Savage, C.L., Finnell, D.S., Choflet, A. (2016). Cancer, Alcohol, and Aging. In: Kuerbis, A., Moore, A., Sacco, P., Zanjani, F. (eds) Alcohol and Aging. Springer, Cham. https://doi.org/10.1007/978-3-319-47233-1_5

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  • DOI: https://doi.org/10.1007/978-3-319-47233-1_5

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  • Online ISBN: 978-3-319-47233-1

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