Abstract
An interaction of blood with artificial materials is an important aspect in designing cardiovascular tissue analogues. The processes occurs on liquid/solid interface depends both on structural and mechanical properties of biomaterials. Main goal of the work was to develop novel blood contacting materials in the form of thin coatings with anti-thrombogenic properties by reduction of shear stress improving sufficient washing of biofunctional-adapted surfaces. Preliminary studies and simulations led us to carbon based thin coatings considered as silicon doped amorphous carbon. The rigidity of the surface design of materials dedicated for the biomedical purpose is of particular importance. The paper presents an analysis of the impact of material stiffness and mechanical for interaction with blood cells. Material analysis of in the context of the mechanical properties showed changes in stiffness depending on the thickness of the coating. The Young modulus and hardness of materials were examined by indentation test using Berkovich indenter geometry. Cell-material interactions were assessed using the cellular components of blood. Shear stress on the between the cell-and material were considered taking into account red blood cells and platelets concentrates.
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Acknowlegement
The research was financially supported by the Project no. 2014/13/B/ST8/04287 “Bio-inspired thin film materials with the controlled contribution of the residual stress in terms of the restoration of stem cells microenvironment” of the Polish National Centre of Science. Part of the research has been done in the frame of statutory funds of the Institute of Metallurgy and Materials Science PAS, the task Z-2.
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Trembecka-Wojciga, K., Major, R., Wilczek, P., Lackner, J.M., Jasek-Gajda, E., Major, B. (2017). The Influence of the Mechanical Properties of a-C:H Based Thin Coatings on Blood-Material Interaction. In: Gzik, M., Tkacz, E., Paszenda, Z., Piętka, E. (eds) Innovations in Biomedical Engineering. Advances in Intelligent Systems and Computing, vol 526. Springer, Cham. https://doi.org/10.1007/978-3-319-47154-9_11
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DOI: https://doi.org/10.1007/978-3-319-47154-9_11
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