Skip to main content

HBO Therapy in Cardiovascular Diseases

  • Chapter
Textbook of Hyperbaric Medicine
  • 2315 Accesses

Abstract

Hyperbaric oxygen (HBO) has been found to be useful in the management of myocardial ischemia, as an adjunct to cardiac surgery, and for improving the walking distance in ischemic limb pain. The role of HBO in various cardiovascular disorders is described. Experimental studies as well as clinical experience are reviewed. HBO can be used for the emergency management of cardiogenic shock. A rational basis is provided for the effectiveness of HBO.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 249.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 329.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Ackerman NB, Brinkley FB. Oxygen tensions in normal and ischemic tissues during hyperbaric therapy. JAMA. 1966;98:142–5.

    Google Scholar 

  • Allaria B, Decio B, Libutti M. Electrocution and hyperbaric oxygen therapy: a case with electrocardiographic changes from electrocution cured by hyperbaric oxygen therapy. Anesteziol Reanimatol. 1973;14:167–72.

    Google Scholar 

  • Allen MW, Golembe E, Gorenstein S, Butler GJ. Protective effects of hyperbaric oxygen therapy (HBO2) in cardiac care—a proposal to conduct a study into the effects of hyperbaric pre-conditioning in elective coronary artery bypass graft surgery (CABG). Undersea Hyperb Med. 2015;42:107–14.

    PubMed  Google Scholar 

  • Bakay-Csorba PA, Provan JL, Ameli FM. Transcutaneous oxygen tension measurements in the detection of iliac and femoral arterial disease. Surg Gynecol Obstet. 1987;164:102–4.

    Google Scholar 

  • Banham ND. Livedoid vasculopathy successfully treated with hyperbaric oxygen. Diving Hyperb Med. 2013;43:35–6.

    PubMed  Google Scholar 

  • Barcal R, Emmerova M, Sova J, Topinka I, Hadravský M. Hyperbaric oxygen therapy of cardiogenic shock in the acute stage of myocardial infarction. Cas Lek Cesk. 1975;114:259–62.

    CAS  PubMed  Google Scholar 

  • Bennett MH, Lehm JP, Jepson N. Hyperbaric oxygen therapy for acute coronary syndrome. Cochrane Database Syst Rev. 2015;7, CD004818.

    Google Scholar 

  • Bird AD, Telfer ABM. Effect of hyperbaric oxygen on limb circulation. Lancet. 1965;13:355–6.

    Article  Google Scholar 

  • Bockeria LA, Khapy KH, Gazhiev AA, et al. Extracorporeal circulation under hyperbaric oxygenation. In: Smith G, editor. 5th international congress on hyperbaric medicine. Aberdeen: University of Aberdeen Press; 1977. p. 189–97.

    Google Scholar 

  • Bockeria LA, Sokolova NA, Ladynima EA, Gadzhiev AA. Enzyme determinants as a check on adequacy of body defences during heart operations under hyperbaric oxygenation. Anesteziol Reanimatol. 1978;3:45–9.

    Google Scholar 

  • Bockeria LA, Zelenkini MA. Electrocardiographic changes during exclusion of the heart from the circulation under hyperbaric oxygenation and hypothermia (in Russian). Eksp Khir Anestesiol. 1973;18:80–4.

    Google Scholar 

  • Boerema I, Meyne NG, Brummelkamp WH, Bouma S, Mensch MH, Kamermans F, et al. Life without blood. Arch Chir Neer. 1959;11:70–83.

    Google Scholar 

  • Boerema I. An operating room for high oxygen pressure. Surgery. 1961;47:291–8.

    Google Scholar 

  • Burakovsky VI, Bockeria LA. Experience of operating on the heart under conditions of hyperbaric oxygen. In: Proceedings of the 7th international congress on hyperbaric medicine, Moscow, Sept. 2–6, 1981.

    Google Scholar 

  • Burakovsky VI, Bockeria LA. The resuscitative value of HBO in cardiac surgery and cardiology. In: Smith G, editor. 6th international congress on hyperbaric medicine. Aberdeen: University of Aberdeen Press; 1977. p. 184–8.

    Google Scholar 

  • Bylund-Fellenius AC, Elander A, Lundgren F. Effects of reduced blood flow on human muscle metabolism. In: OkyayuzBaklonti I, Hudlicka O, editors. Muscle ischemia – functional and metabolic aspects. Wolff: Munich; 1987. p. 75–88.

    Google Scholar 

  • Cameron AJV, Hutton I, Kenmure ACF, Murdoch WR. Haemodynamic and metabolic effects of hyperbaric oxygen in myocardial infarction. Lancet. 1966;i:833–7.

    Article  Google Scholar 

  • Chardack WM, Gage AA, Frederico AJ, Cusick JK, Matsumoto PJ, Lanphier EH. Reduction by hyperbaric oxygenation of the mortality from ventricular fibrillation following coronary artery ligation. Circ Res. 1964;15:497–502.

    Article  CAS  PubMed  Google Scholar 

  • Clark RG, Young DG. Effects of hyperoxygenation and sodium bicarbonate in hemorrhagic hypotension. Br J Surg. 1965;52:704.

    Article  CAS  PubMed  Google Scholar 

  • De Myttenaere S, Heifetz M, Shilansky H, Monies I, Shramek A. Different treatments used in a case of gangrene due to accidental intraarterial injection of methylphenidate (Ritalin). Anesth Analg. 1977;34:405–10.

    Google Scholar 

  • Demurov EA, Vesilieva NN, Kakhnovskaya VB, et al. The effect of hyperbaric oxygenation on some indices of neurohormonal regulation, metabolic and heart contractile function under conditions of acute occlusion of the coronary artery. In: Yefuny SN, editor. Proceedings of the 7th international congress on hyperbaric medicine. USSR Academy of Sciences, Moscow, 1981:273.

    Google Scholar 

  • Dotsenko EA, Nikulina NV, Salivonchik DP, Lappo OG, Gritsuk AI, Bastron AS. Low doses of hyperbaric oxygenation effectively decrease the size of necrotic zone in rats with experimental myocardial infarction. Bull Exp Biol Med. 2015;158:732–4.

    Article  CAS  PubMed  Google Scholar 

  • Efuni SN, Kudryashev V, Rodionov VV, et al. Significance of the isometric test in the objective assessment of the efficacy of hyperbaric oxygenation in coronary heart disease. Kardiologiia. 1984;24:77–80.

    CAS  PubMed  Google Scholar 

  • Ehrly AM, Saeger-Lorenz K. Einfluss von Pentoxifyllin auf den Muskelgewebesauerstoffdruck von Patienten mit Claudicatio intermittens vor und nach fussergometrischer Belastung. Med Welt. 1988;39:739–44.

    Google Scholar 

  • Eisterer H, Staudacher M. Die Anwendung der hyperbaren Sauerstoffkammer in Verbindung mit gefässrekonstruktiven Massnahmen. Chirurg. 1971;42:187–90.

    CAS  PubMed  Google Scholar 

  • Elander A, Idström JP, Schersten T, Bylund-Fellenius AC. Metabolic adaptation to reduced muscle blood flow. I. Enzyme and metabolite alterations. Am J Physiol. 1985;249:E63–9.

    Article  CAS  PubMed  Google Scholar 

  • Fredenucci P. Oxygénothérapie hyperbare et artériopathies. J Mal Vasc. 1985;10(Suppl A):166–72.

    PubMed  Google Scholar 

  • Friehs G, Klepp G, Rader W, Schalk H, Stolze A. Hyperbaric oxygenation in a large hyperbaric chamber. Med Klin. 1977;72:2013–8.

    CAS  PubMed  Google Scholar 

  • Gadzhiev AA. Prevention of venous hypertension on the dry heart under hyperbaric oxygenation. Grudn Khir. 1979;5:7–10.

    Google Scholar 

  • Goliakov VN, Eroshina VA, Zimin YV, Semiletova VI. Hemostasis in patients with ischemic heart disease during hyperbaric oxygenation. Klin Med (Mosk). 1986a;64:92–5.

    CAS  Google Scholar 

  • Goliakov VN, Zimin IV, Eroshina VA, Gasilin VS, Efuni SN. Effect of hyperbaric oxygenation on extrasystole in ischemic heart disease patients. Kardiologiia. 1986b;26:45–9.

    CAS  PubMed  Google Scholar 

  • Gorman JF, Stansell GB, Douglas F. Limitations of hyperbaric oxygenation in occlusive arterial disease. Circulation. 1965;32:936–9.

    Article  CAS  PubMed  Google Scholar 

  • Gross DR, Dodd KT, Welch DW, Fife WP. Hemodynamic effects of 10 % dextrose and of dextran 70 on hemorrhagic shock during exposure to hyperbaric air and hyperbaric hyperoxia. Aviat Space Environ Med. 1984;55:1118–28.

    CAS  PubMed  Google Scholar 

  • Gross DR, Moreau RM, Chaikin BN, Welch DW, Jabor M, Fife WP. Hemodynamic effects of lactated Ringer’s solution on hemorrhagic shock during exposure to hyperbaric air and hyperbaric hyperoxia. Aviat Space Environ Med. 1983a;54:701–8.

    CAS  PubMed  Google Scholar 

  • Gross DR, Moreau RM, Jabor M, Welch DW, Fife WP. Hemodynamic effects of dextran 40 on hemorrhagic shock during hyperbaria and hyperbaric hyperoxia. Aviat Space Environ Med. 1983b;54:413–9.

    CAS  PubMed  Google Scholar 

  • Illingworth CFW. Treatment of arterial occlusion under oxygen at two atmospheres pressure. Br Med J. 1962;2:1271–5.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Isakov IV, Golikov AP, Ustinova EZ, Tret'iakova NG. Hyperbaric oxygenation in the combined treatment of paroxysmal tachyarrhythmias in ischemic heart disease. Kardiologiia. 1981;21:42–5.

    PubMed  Google Scholar 

  • Jacobson JH, Wang MCH, Yamaki T, Kline HJ, Kark AE, Kuhn LA. Hyperbaric oxygenation in diffuse myocardial infarction. Arch Surg. 1964;89:905.

    Article  CAS  PubMed  Google Scholar 

  • Jain KK. Oxygen in Physiology and Medicine. Charles C Thomas: Springfield, IL; 1989.

    Google Scholar 

  • Jeysen ZY, Gerard L, Levant G, Cowen M, Cale A, Griffin S. Research report: the effects of hyperbaric oxygen preconditioning on myocardial biomarkers of cardioprotection in patients having coronary artery bypass graft surgery. Undersea Hyperb Med. 2011;38:175–85.

    PubMed  Google Scholar 

  • Kawamura MK, Sakakibara K, Sasakibara B. Protective effect of hyperbaric oxygen for the temporary ischemic myocardium. Macroscopic and histologic data. Cardiovasc Res. 1976;10:599–601.

    Article  CAS  PubMed  Google Scholar 

  • Kawamura MK, Sakakibara K, Yusa T. Effect of increased oxygen on peripheral circulation in acute, temporary limb hypoxia. J Cardiovasc Surg. 1978;19:161–8.

    CAS  Google Scholar 

  • Kim CH, Choi H, Chun YS, Kim GT, Park JW, Kim MS. Hyperbaric oxygenation pretreatment induces catalase and reduces infarct size in ischemic rat myocardium. Pflugers Arch. 2001;442:519–25.

    Article  CAS  PubMed  Google Scholar 

  • Kleep G. Additive Wirkung von hyperbarem Sauerstoff und intraaortaler Ballonpumpe bei der Therapie des akuten Koronarverschlusses im Experiment. Wien Med Wochenschr. 1977;127:35.

    Google Scholar 

  • Kline HJ, Marano AJ, Johnson CD, Goodman P, Jacobson 2nd JH, Kuhn LA. Hemodynamics and metabolic effects of hyperbaric oxygenation in myocardial infarction. J Appl Physiol. 1979;28:256–63.

    Article  Google Scholar 

  • Kostiunin VN, Pahkomov VI, Feoktistov PL, Petrova EA. Increasing the effectiveness of hyperbaric oxygenation in the treatment of patients with stage IV arterial occlusive disease of the lower limbs. Vestn Khir. 1985;135:48–51.

    CAS  PubMed  Google Scholar 

  • Kovacevic H. The Investigation of Hyperbaric Oxygen Influence in the Patients with Second Degree of Atherosclerotic Insufficiency of Lower Extremities. Doctoral Dissertation: University of Rijeka, Croatia; 1992.

    Google Scholar 

  • Kudchodkar BJ, Pierce A, Dory L. Chronic hyperbaric oxygen treatment elicits an anti-oxidant response and attenuates atherosclerosis in apoE knockout mice. Atherosclerosis. 2007;193:28–35.

    Article  CAS  PubMed  Google Scholar 

  • Kuleshova MP, Flora AA. Physical rehabilitation of patients with ischemic heart disease using hyperbaric oxygen. In: Yefuny SN, editor. Proceedings of the 7th international congress of hyperbaric medicine, USSR Academy of Sciences, Moscow, 1981:p 268.

    Google Scholar 

  • Lambert MA, Belch JJ. Medical management of critical limb ischaemia: where do we stand today? J Intern Med. 2013;274:295–307.

    Article  CAS  PubMed  Google Scholar 

  • Li Y, Dong H, Chen M, Liu J, Yang L, Chen S, et al. Preconditioning with repeated hyperbaric oxygen induces myocardial and cerebral protection in patients undergoing coronary artery bypass graft surgery: a prospective, randomized, controlled clinical trial. J Cardiothorac Vasc Anesth. 2011;25:908–16.

    Article  PubMed  Google Scholar 

  • Lundgren F, Zachrisson H, Emery P, Bylund-Fellenius AC, Elander A, Bennegård K, et al. Less exchange of amino acids during exercise in patients with arterial insufficiency. Clin Physiol. 1988;8:227–41.

    Article  CAS  PubMed  Google Scholar 

  • Lusiani L, Visona A, Nicolin P, Papesso B, Pagnan A. Transcutaneous oxygen tension (TcPO2) measurement as a diagnostic tool in patients with peripheral vascular disease. Angiology. 1988;39:873–80.

    Article  CAS  PubMed  Google Scholar 

  • Mangiafico RA, Mangiafico M. Medical treatment of critical limb ischemia: current state and future directions. Curr Vasc Pharmacol. 2011;9:658–76.

    Article  CAS  PubMed  Google Scholar 

  • Merrick J, Gufler K, Jacobsen E. Ergotism treated with hyperbaric oxygen and continuous epidural analgesia. Acta Anaesthesiol Scand. 1978;Suppl 67: 87–90.

    Google Scholar 

  • Miroshnichenko VP, Demurov EA, Koloskow YB, Zubovskaia AM. Effect of guanine nucleotides and hyperbaric oxygenation on cardiac adenylate cyclase activity in rabbits with myocardial hypertrophy. Bull Exp Biol Med. 1983;95:179–81.

    Article  Google Scholar 

  • Monies-Chass I, Herer D, Alon U, Birkhahn HJ. Hyperbaric oxygen in acute ischaemia due to allergic vasculitis. Anaesthesia. 1976;31:1221–4.

    Article  CAS  PubMed  Google Scholar 

  • Nylander G, Lewis D, Nordstrom H, Larsson J. Reduction of postischemic edema with hyperbaric oxygen. Plast Reconstr Surg. 1985;76:596–603.

    Article  CAS  PubMed  Google Scholar 

  • Richards V, Pinto D, Coombs P. Studies in suspended animation by hypothermia combined with hyperbaric oxygenation. Ann Surg. 1963;58:349–62.

    Article  Google Scholar 

  • Rosenthal E, Benderly A, Monies-Chass I, Fishman J, Levy J, Bialik V. Hyperbaric oxygenation in peripheral ischaemic lesions in infants. Arch Dis Child. 1985;60:372–4.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sakakibara K. The history and future prospects of hyperbaric oxygen therapy in japan. Jpn J Hyperbaric Med. 1986;21:21–40.

    Google Scholar 

  • Scheidt S, Wilner G, Fillmore S, Shapiro M, Killip T. Objective haemodynamic assessment after acute myocardial infarction. Br Heart J. 1973;35:908–16.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schraibman IG, Ledingham IM. Hyperbaric oxygen and local vasodilatation in peripheral vascular disease. Brit J Surg. 1969;56:295–9.

    Article  CAS  PubMed  Google Scholar 

  • Shandling AH, Ellestad MH, Hart GB, Crump R, Marlow D, Van Natta B, et al. Hyperbaric oxygen and thrombolysis in myocardial infarction: the “hot MI” pilot study. Am Heart J. 1997;134:544–50.

    Article  CAS  PubMed  Google Scholar 

  • Sjöström M, Neglen P, Friden J, Eklof B. Human skeletal muscle metabolism and morphology after temporary incomplete ischaemia. Eur J Clin Invest. 1982;12:69–79.

    Article  PubMed  Google Scholar 

  • Smetnev AS, Efuni SN, Rodionov VV, Ashurova LD, Aslibekian IS. Hyperbaric oxygenation in the overall therapy of chronic ischemic heart disease. Kardiologiia. 1979;19:41–6.

    CAS  PubMed  Google Scholar 

  • Smith G, Lawson DA. Experimental coronary arterial occlusion: effects of the administration of oxygen under pressure. Scott Med J. 1958;3:346–50.

    Article  CAS  PubMed  Google Scholar 

  • Spears JR, Henney C, Prcevski P, Xu R, Li L, Brereton GJ, et al. Aqueous oxygen hyperbaric reperfusion in a porcine model of myocardial infarction. J Invasive Cardiol. 2002;14:160–6.

    PubMed  Google Scholar 

  • Stalker CG, Ledingham IM. The effect of increased oxygen in prolonged acute on limb ischaemia. Br J Surg. 1973;60:959–63.

    Article  CAS  PubMed  Google Scholar 

  • Sterling DL, Thornton JD, Swafford A, Gottlieb SF, Bishop SP, Stanley AW, et al. Hyperbaric oxygen limits infarct size in ischemic rabbit myocardium in vivo. Circulation. 1993;88:1931–6.

    Article  CAS  PubMed  Google Scholar 

  • Stillman RM. Effects of hypoxia and hyperoxia on progression of intimal healing. Arch Surg. 1983;118:732–7.

    Article  CAS  PubMed  Google Scholar 

  • Stravinsky Y, Shandling AH, Ellestad MH, Hart GB, Van Natta B, Messenger JC, et al. Hyperbaric oxygen and thrombolysis in myocardial infarction: the ‘HOT MI’ randomized multicenter study. Cardiology. 1998;90:131–6.

    Article  Google Scholar 

  • Thomas MP, Brown LA, Sponseller DR, Williamson SE, Diaz JA, Guyton DP. Myocardial infarct size reduction by the synergistic effect of hyperbaric oxygen and recombinant tissue plasminogen activator. Am Heart J. 1990;120:791–800.

    Article  CAS  PubMed  Google Scholar 

  • Thurston JG, Greenwood TW, Bending MR, Connor H, Curwen MP. A controlled investigation into the effects of hyperbaric oxygen on mortality following acute myocardial infarction. Q J Med. 1973;42:751–70.

    CAS  PubMed  Google Scholar 

  • Todo K, Nakae S, Wada J. Heart preservation with metabolic inhibitor, hypothermia, and hyperbaric oxygenation. Jpn J Surg. 1974;4:29–36.

    Article  CAS  PubMed  Google Scholar 

  • Trapp WG, Creighton R. Experimental studies of increased atmospheric pressure on myocardial ischemia after coronary ligation. J Thorac Cardiovasc Surg. 1964;47:687–92.

    Article  CAS  PubMed  Google Scholar 

  • Urayama H, Takemura H, Kasajima F, Tsuchida K, Katada S, Watanabe Y. Hyperbaric oxygen therapy for chronic occlusive disease of the extremities. Nippon Geka Gakkai Zasshi. 1992;93:429–33.

    CAS  PubMed  Google Scholar 

  • Visona A, Lusiani L, Rusca F, Barbiero D, Ursini F, Pagnan A. Therapeutic, hemodynamic, and metabolic effects of hyperbaric oxygenation in peripheral vascular disease. Angiology. 1989;40:994–1000.

    Article  CAS  PubMed  Google Scholar 

  • Yin X, Wang X, Fan Z, Peng C, Ren Z, Huang L, et al. Hyperbaric Oxygen Preconditioning Attenuates Myocardium Ischemia-Reperfusion Injury Through Upregulation of Heme Oxygenase 1 Expression: PI3K/Akt/Nrf2 Pathway Involved. J Cardiovasc Pharmacol Ther. 2015;20:428–38.

    Article  CAS  PubMed  Google Scholar 

  • Yogaratnam JZ, Laden G, Guvendik L, Cowen M, Cale A, Griffin S. Pharmacological preconditioning with hyperbaric oxygen: can this therapy attenuate myocardial ischemic reperfusion injury and induce myocardial protection via nitric oxide? J Surg Res. 2008;149:155–64.

    Article  CAS  PubMed  Google Scholar 

  • Zhivoderov VM, Doshchitsin VL, Dunaeva ZI, Kolomeĭtseva SP, Nazarova VI. Late arrhythmias in myocardial infarct. Kardiologiia. 1980;20:22–5.

    CAS  PubMed  Google Scholar 

  • Zhivoderov VM, Zakharov VN, Doshchitsin VL, Kolomeĭtseva SP, Aksenova TN. Use of hyperbaric oxygenation for treating arrhythmias in ischemic heart disease. Klin Med (Mosk). 1982;60:51–5.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to K. K. Jain MD, FRACS, FFPM .

Rights and permissions

Reprints and permissions

Copyright information

© 2017 Springer International Publishing AG

About this chapter

Cite this chapter

Jain, K.K. (2017). HBO Therapy in Cardiovascular Diseases. In: Textbook of Hyperbaric Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-47140-2_25

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-47140-2_25

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-47138-9

  • Online ISBN: 978-3-319-47140-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics