Abstract
The detection of brain alterations is crucial for understanding pathophysiological processes. The Voxel-Based Morphometry (VBM) is one of the most popular methods to achieve this task. Despite its numerous advantages, VBM is based on a highly reduced representation of the local brain anatomy since complex anatomical patterns are reduced to local averages of tissue probabilities. In this paper, we propose a new framework called Sparse-Based Morphometry (SBM) to better represent local brain anatomies. The presented patch-based approach uses dictionary learning to detect anatomical pattern modifications based on their shape and geometry. In our experiences, we compare SBM and VBM along Alzheimer’s Disease (AD) progression.
Data used in preparation of this article were obtained from the Alzheimer’s Disease Neuroimaging Initiative (ADNI) database (adni.loni.usc.edu). As such, the investigators within the ADNI contributed to the design and implementation of ADNI and/or provided data but did not participate in analysis or writing of this report. A complete listing of ADNI investigators can be found at: http://adni.loni.usc.edu/wp-content/uploads/how_to_apply/ADNI_Acknowledgement_List.pdf.
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Acknowledgments
This study has been carried out with financial support from the French State, managed by the French National Research Agency (ANR) in the frame of the Investments for the future Program IdEx Bordeaux (HL-MRI ANR-10-IDEX-03-02), Clusters of excellence CPU and TRAIL (HR-DTI ANR-10-LABX-57) and the CNRS multidisciplinary project “Défi imag’In”.
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Coupé, P., Deledalle, CA., Dossal, C., Allard, M., Alzheimer’s Disease Neuroimaging Initiative. (2016). Sparse-Based Morphometry: Principle and Application to Alzheimer’s Disease. In: Wu, G., Coupé, P., Zhan, Y., Munsell, B., Rueckert, D. (eds) Patch-Based Techniques in Medical Imaging. Patch-MI 2016. Lecture Notes in Computer Science(), vol 9993. Springer, Cham. https://doi.org/10.1007/978-3-319-47118-1_6
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DOI: https://doi.org/10.1007/978-3-319-47118-1_6
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