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Moving from Genetics to Systems Biology

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Philosophy of Systems Biology

Part of the book series: History, Philosophy and Theory of the Life Sciences ((HPTL,volume 20))

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Access to competence in mathematical modelling may be a major hindrance for employing a systems biology approach in many research projects. Very commonly, the most successful systems biology studies are based on collaborations between experimentalists, contributing with the biological questions and experimental data and theoreticians, who contribute with skills in modelling, simulation and prediction. Collaboration across disciplines is not a trivial enterprise and very commonly requires skills to communicate across borders. This challenge, as well as the mere availability of matching theoreticians locally may prevent in many cases the integration of modelling and prediction into projects even if the interdisciplinary approaches offer great potential.”

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Suggested Readings by Stefan Hohmann

  • Cvijovic, M., Höfer, T., Acimovic, J., Alberghina, L., Almaas, E., Besozzi, D., … De Atauri, P. (2016). Strategies for structuring interdisciplinary education in systems biology: An European perspective. NPJ Systems Biology and Applications, 2, 16011.

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  • Hohmann, S. (2002). Osmotic stress signaling and osmoadaptation in yeasts. Microbiology and Molecular Biology Reviews, 66, 300–372.

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  • Klipp, E., Nordlander, B., Krüger, R., Gennemark, P., & Hohmann, S. (2005). Integrative model of the response of yeast to osmotic shock. Nature Biotechnology, 23, 975–982.

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Hohmann, S. (2017). Moving from Genetics to Systems Biology. In: Green, S. (eds) Philosophy of Systems Biology. History, Philosophy and Theory of the Life Sciences, vol 20. Springer, Cham. https://doi.org/10.1007/978-3-319-47000-9_12

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