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“The systems biology lens situates the phenomenon of life somewhere between molecule and autonomous organism. The focus throughout is on organism: life emerges from a system of material components that are functionally organised in such a way that the system can autonomously and continuously produce and repair itself, can distinguish itself from the rest of the world, and can adaptively restructure itself within its genomic constraints in the face of environment fluctuations. Systems biology therefore goes beyond the properties of individual biomolecules, taking seriously their organisation into a living whole.”
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Some key publications that illuminated my research path (and some of my own)
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Suggested Readings by Jan-Hendrik S. Hofmeyr
Hofmeyr, J. -H. S. (2007). The biochemical factory that autonomously fabricates itself: A systems-biological view of the living cell. In F. C. Boogerd, F. Bruggeman, J. -H. S.Hofmeyr & H. V. Westerhoff (Eds.), Systems biology: Philosophical foundations (pp. 217–242). Amsterdam: Elsevier.
Hofmeyr, J. -H. S., & Cornish-Bowden, A. (2000). Regulating the cellular economy of supply and demand. FEBS Letters, 476, 47–51.
Wolkenhauer, O., & Hofmeyr, J. H. S. (2007). An abstract cell model that describes the self-organization of cell function in living systems. Journal of theoretical biology, 246, 461–476.
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Hofmeyr, JH.S. (2017). Exploring the Metabolic Marketplace Through the Lens of Systems Biology. In: Green, S. (eds) Philosophy of Systems Biology. History, Philosophy and Theory of the Life Sciences, vol 20. Springer, Cham. https://doi.org/10.1007/978-3-319-47000-9_11
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