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Atlas of Graft-versus-Host Disease pp 105–123Cite as

Pediatric Graft-Versus-Host Disease

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Abstract

Children undergo hematopoietic stem cell transplantation (HSCT) for a variety of reasons: hematologic malignancies, select visceral organ malignancies, bone marrow failures, immunodeficiencies, metabolic disorders, autoimmune disorders, and other life-threatening conditions [1, 2]. In 2013, 13 % of HSCT patients in the United States were younger than 21 years of age [3]. As in adults, acute and chronic graft-versus-host disease (GVHD) are among the most important causes of nonrelapse mortality in children after HSCT. Most GVHD literature focuses on adult patients, however, and is not universally applicable to pediatric patients. This chapter focuses on unique characteristics of acute and chronic GVHD in children, highlighting both what is known and what is yet to be understood about these complex diseases.

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Acknowledgment

Photographs are courtesy of Dr. Jennifer T. Huang.

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Authors and Affiliations

  1. Department of Dermatology, School of Medicine, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR, USA

    Valerie Carlberg

  2. Dermatology Program, Boston Children’s Hospital, 300 Longwood Avenue, Boston, MA, USA

    Emily Simons

  3. Division of Dermatology, Department of Medicine, University of Massachusetts Medical School, 55 North Lake Avenue, Worcester, MA, USA

    Sophia Delano

  4. Department of Dermatology, Harvard Medical School, Dermatology Program, Boston Children’s Hospital, Fegan 6, Dermatology Program, 300 Longwood Avenue, Boston, MA, USA

    Jennifer T. Huang

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  1. Valerie Carlberg
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  2. Emily Simons
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Correspondence to Jennifer T. Huang .

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Editors and Affiliations

  1. Division of Dermatology, City of Hope National Medical Center Division of Dermatology, Durante, California, USA

    Jonathan A. Cotliar

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Carlberg, V., Simons, E., Delano, S., Huang, J.T. (2017). Pediatric Graft-Versus-Host Disease. In: Cotliar, J. (eds) Atlas of Graft-versus-Host Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-46952-2_9

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