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Atlas of Graft-versus-Host Disease pp 149–160Cite as

Atypical Manifestations of Graft-Versus-Host Disease

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Abstract

The cutaneous manifestations of graft-versus-host disease (GVHD) are protean and often diagnostically challenging. Acute GVHD (aGVHD) of the skin most often presents with a morbilliform exanthem, which may progress to generalized erythema and bullae in severe cases, bearing striking resemblance to toxic epidermal necrolysis. The manifestations of chronic GVHD (cGVHD) are more diverse and often resemble other dermatologic conditions. For example, diagnostic signs of cGVHD, based on the NIH Consensus Criteria, include poikiloderma, lichen planus-like features, sclerotic features, morphea-like features, and lichen sclerosus-like features [1]. More atypical presentations of cutaneous GVHD also often mimic other disorders, in which case histologic findings supportive of GVHD can help establish the diagnosis. This chapter highlights the many atypical and under-recognized manifestations of both acute and chronic cutaneous GVHD (Table 12.1).

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Authors and Affiliations

  1. Department of Dermatology, Perelman School of Medicine, University of Pennsylvania, 3600 Spruce Street, 2 Maloney Building, Philadelphia, PA, 19104, USA

    Christine M. Cornejo

  2. Department of Dermatology and Medicine, Perelman School of Medicine, University of Pennsylvania, 3600 Spruce Street, 2 Maloney Building, Philadelphia, PA, 19104, USA

    Robert G. Micheletti

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  1. Christine M. Cornejo
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Correspondence to Robert G. Micheletti .

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  1. Division of Dermatology, City of Hope National Medical Center Division of Dermatology, Durante, California, USA

    Jonathan A. Cotliar

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Cornejo, C.M., Micheletti, R.G. (2017). Atypical Manifestations of Graft-Versus-Host Disease. In: Cotliar, J. (eds) Atlas of Graft-versus-Host Disease. Springer, Cham. https://doi.org/10.1007/978-3-319-46952-2_12

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