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Mesenchymal Stem Cells and Immunomodulation pp 75–82Cite as

Controversies in the Use of Mesenchymal Stem Cells for Treating Autoimmune Diseases

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Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

Mesenchymal stem cells are being assessed in clinical trials to determine whether cell-based therapy can alter the progression of various autoimmune and degenerative diseases. Despite relatively positive results showing that mesenchymal stem cells possess potent immunomodulatory activity including their capacity to induce peripheral tolerance, immunomodulation using these cells is not without controversy. For example, mesenchymal stem cell-based repair of cartilage defects could also result in tumor development resulting from their migration to the tumor cell stroma. In the context of using mesenchymal stem cells for future synovial joint reconstruction, it will be necessary to find ways to curtail the capacity of mesenchymal stem cells to become fully differentiated. In addition, the extent to which allogeneic mesenchymal stem cells can actually reverse pathology in an experimental mouse model of lupus is yet another controversial issue that must be fully explored before contemplating their use in the treatment of human lupus.

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Author information

Authors and Affiliations

  1. Division of Rheumatic Diseases, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA

    Zachary Wolff M.D. & Charles J. Malemud Ph.D.

  2. Division of Rheumatic Diseases, Department of Medicine, University Hospitals Cleveland Medical Center, Foley Medical Building, 2061 Cornell Road, Cleveland, OH, 44106-5076, USA

    Charles J. Malemud Ph.D.

Authors
  1. Zachary Wolff M.D.
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  2. Charles J. Malemud Ph.D.
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Corresponding author

Correspondence to Charles J. Malemud Ph.D. .

Editor information

Editors and Affiliations

  1. Division of Rheumatic Diseases Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA

    Charles J. Malemud

  2. Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA

    Eben Alsberg

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© 2016 Springer International Publishing AG

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Wolff, Z., Malemud, C.J. (2016). Controversies in the Use of Mesenchymal Stem Cells for Treating Autoimmune Diseases. In: Malemud, C., Alsberg, E. (eds) Mesenchymal Stem Cells and Immunomodulation. Stem Cell Biology and Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-319-46733-7_6

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