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Antimicrobial Drug Resistance pp 213–229Cite as

Aminoglycosides: Mechanisms of Action and Resistance

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Abstract

Aminoglycosides have been an important part of the antimicrobial armamentarium since their introduction into clinical use in the 1940s. The spectrum of activity, rapid bactericidal activity, and favorable chemical and pharmacokinetic properties of aminoglycosides make them a clinically useful class of drugs. Although the introduction of efficacious and less toxic agents such as the broad-spectrum β-lactam antimicrobials led to a shift away from the use of aminoglycosides, the recent emergence of multi- and extensively drug-resistant Gram-negative pathogens has led to renewed interest in the aminoglycoside class, including the development of new molecules with potent activity against otherwise highly resistant pathogens.

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Authors and Affiliations

  1. Achaogen, Inc., 7000 Shoreline Court, Suite 371, South San Francisco, CA, 94080, USA

    Alisa W. Serio Ph.D. & Lynn E. Connolly M.D., Ph.D.

  2. Department of Food and Animal Production, State University of Santa Catarina, Lages, SC, 88520-000, Brazil

    Maria L. Magalhães

  3. Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY, 10461, USA

    John S. Blanchard Ph.D.

  4. Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, CA, 94143, USA

    Lynn E. Connolly M.D., Ph.D.

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  1. Alisa W. Serio Ph.D.
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Correspondence to Lynn E. Connolly M.D., Ph.D. .

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  1. Treiber Therapeutics, Cambridge, Massachusetts, USA

    Douglas L. Mayers

  2. Wayne State University School of Medicine, Detroit Medical Center, Detroit, Michigan, USA

    Jack D. Sobel

  3. Centre de recherche en Infectiologie, University of Laval, Quebec City, Canada

    Marc Ouellette

  4. Division of Infectious Diseases, University of Michigan Medical School, Ann Arbor, Michigan, USA

    Keith S. Kaye

  5. Infection Control and Prevention Unit of Infectious Diseases, Assaf Harofeh Medical Center, Sackler Faculty of Medicine, Tel-Aviv University, Tel Aviv, Israel

    Dror Marchaim

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Serio, A.W., Magalhães, M.L., Blanchard, J.S., Connolly, L.E. (2017). Aminoglycosides: Mechanisms of Action and Resistance. In: Mayers, D., Sobel, J., Ouellette, M., Kaye, K., Marchaim, D. (eds) Antimicrobial Drug Resistance. Springer, Cham. https://doi.org/10.1007/978-3-319-46718-4_14

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