Abstract
Cardiovascular disease is the leading cause of death in the Western world. One of the major underlying pathologies of cardiovascular disease is atherosclerosis. Atherogenesis is a multifactorial process; hypercholesterolemia represents a major risk factor for atherosclerotic changes. Hypolipidemic drugs including statins have paramount importance in managing patients with chronic cardiovascular disease.
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Summary Table
Summary Table
Clinical summary | ||||
|---|---|---|---|---|
Indications | Cautions | Side effects | Dose | Notes |
Hypercholesterolemia Primary and secondary prevention of cardiovascular disease | Muscle-related (myalgia, myopathy, myonecrosis, rhabdomyolysis) in 1.5–5 % of the patients Isolated increase in liver enzymes (usually benign) | Depending on particular statin: 10–80 mg once daily | Statin therapy should be continued in perioperative period | |
Reducing perioperative risk in cardiac, vascular, and major noncardiac surgery | Possible increased occurrence of postoperative AKI and ambiguous effect on mortality | Existing statin therapy should be continued; commencement of new statin therapy treatment before the surgery (1–3 weeks) could be considered with appropriate caution | ||
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Riha, H., Drabek, T. (2017). Statins and Perioperative Mortality. In: Landoni, G., Ruggeri, L., Zangrillo, A. (eds) Reducing Mortality in the Perioperative Period. Springer, Cham. https://doi.org/10.1007/978-3-319-46696-5_16
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DOI: https://doi.org/10.1007/978-3-319-46696-5_16
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