Abstract
A proper oxygen and nutrients’ supply is physiologically essential. Similarly, a prompt removal of carbon dioxide and catabolites is as much important. For these reasons, it is fundamental to assure an efficient blood perfusion to all tissues at any time. This is possible thanks to three strictly associated components: (1) the heart, (2) the vascular system (arterial and venous), and (3) the blood. The impairment of even only one of them may seriously compromise tissues’ perfusion and thus cause one or more organ failure.
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Summary Table
Summary Table
Clinical summary | |||||
|---|---|---|---|---|---|
Drugs | Indications | Cautions | Side effects | Dosage | Notes |
Liberal versus restrictive transfusion strategy | Patients undergoing any kind of surgery | Blood transfusion should be individualized taking into account patient’s comorbidities, preexisting chronic anemia, etc. | Transfusion-related immunomodulation, acute lung injury, microcirculatory dysfunction, infection transmission | Depending on hemoglobin level, hemodynamic response, signs of tissue’s suffering, preexisting anemia, or cardiac disease | Further studies are needed so that more accurate indications can be given |
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Fominskiy, E., Votta, C.D., Lomivorotov, V.V. (2017). Liberal Transfusion Strategy in the Perioperative Period. In: Landoni, G., Ruggeri, L., Zangrillo, A. (eds) Reducing Mortality in the Perioperative Period. Springer, Cham. https://doi.org/10.1007/978-3-319-46696-5_14
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DOI: https://doi.org/10.1007/978-3-319-46696-5_14
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