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Stem Cell Therapy for Ischemic Heart Disease

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Liver, Lung and Heart Regeneration

Part of the book series: Stem Cells in Clinical Applications ((SCCA))

Abstract

According to World Health Organization, cardiovascular disease, especially ischemic heart disease, is one of the top ten killers today. Therefore, a growing number of new therapies are being studied for curing this disease from new drug developments to new advance stent creations. Although these methods have given patients more comfortable than previous treatments, they cannot recover or stop the heart failure process. For that reason, regenerative medicine for cardiovascular disease is received much attention from scientist community and stem cell therapy becomes a critical issue of this strategy. This book chapter presents some aspects around stem cell therapy for the ischemic heart disease from general information about the disease, the differentiate ability of stem cells into functional heart cells, stem cell sources, delivery methods, and mechanism of the therapy to the cell dose using in transplantation, safety, and efficiency of the treatment. It is known that embryonic stem cells have a high differentiate potential into cardiomyocytes. However, tumor fertility and ethical issues have been barriers to the cell application in human. Thus, the cell source which is studied and widely used in the treatment trials for cardiovascular disease now is the adult stem cell. There is a variety of different adult stem cell sources such as human bone marrow derived stem cells, human myoblasts, and peripheral blood-derived stem and progenitor cells that are commonly used in clinical trials and showed a high efficient. Also, some other cell sources like adipose derived stem cells and human umbilical cord blood stem cells are also proved to give positive effects on animal models in preclinical studies, so they are potential cell sources for clinical applications. Besides cell materials, delivery routes and cell doses for transplantation are important too. In summary, the positive result of preclinical trials and clinical trials is a big motivation for further research to find a novel effective treatment for heart disease in the future.

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    Truc Le-Buu Pham, Ngoc Bich Vu & Phuc Van Pham

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Pham, T.LB., Vu, N.B., Van Pham, P. (2017). Stem Cell Therapy for Ischemic Heart Disease. In: Pham, P. (eds) Liver, Lung and Heart Regeneration. Stem Cells in Clinical Applications. Springer, Cham. https://doi.org/10.1007/978-3-319-46693-4_10

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