Skip to main content
SpringerLink
Log in

Developing an Implantable Micro Magnetic Stimulation System to Induce Neural Activity in Vivo

  • Conference paper
  • First Online:
Book cover Neural Information Processing (ICONIP 2016)

Part of the book series: Lecture Notes in Computer Science ((LNTCS,volume 9948))

Included in the following conference series:

Abstract

Although electromagnetic stimulation is widely used in neurological studies and clinical applications, conventional electromagnetic stimulation methods have several limitations. Recent studies have reported that micro magnetic stimulation (µMS), which can directly activate neural tissue and cells via sub-millimeter solenoids, has the possibility to overcome such limitations. However, the development and application of µMS using implantable sub-millimeter solenoids has not yet been reported. Here, we proposed a new implantable µMS system and evaluated its validity. In particular, using flavoprotein fluorescence imaging with a high spatial resolution, we evaluated if the stimuli delivered by our system were large enough to activate the mouse auditory cortex in vivo. The results indicated that our system successfully activated neural tissue, and the activity propagation was observed on the brain surface. Thus, this study is the first step to applying µMS implantable devices in investigating basic neuroscience and clinical application tools.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Luan, S., Williams, I., Nikolic, K., Constandinou, T.G.: Neuromodulation: present and emerging methods. Front. Neuroeng. 7, 1–9 (2014)

    Article  Google Scholar 

  2. O’Reardon, J.P., Solvason, H.B., Janicak, P.G., Sampson, S., Isenberg, K.E., Nahas, Z., McDonald, W.M., Avery, D., Fitzgerald, P.B., Loo, C., Demitrack, M.A., George, M.S., Sackeim, H.A.: Efficacy and safety of transcranial magnetic stimulation in the acute treatment of major depression: a multisite randomized controlled trial. Biol. Psychiatry 62, 1208–1216 (2007)

    Article  Google Scholar 

  3. Deuschl, G., Schade-Brittinger, C., Krack, P., Volkmann, J., Schäfer, H., Bötzel, K., Daniels, C., Deutschländer, A., Dillmann, U., Eisner, W., Gruber, D., Hamel, W., Herzog, J., Hilker, R., Klebe, S., Kloß, M., Koy, J., Krause, M., Kupsch, A., Lorenz, D., Lorenzl, S., Mehdorn, H.M., Moringlane, J.R., Oertel, W., Pinsker, M.O., Reichmann, H., Reuß, A., Schneider, G.-H., Schnitzler, A., Steude, U., Sturm, V., Timmermann, L., Tronnier, V., Trottenberg, T., Wojtecki, L., Wolf, E., Poewe, W., Voges, J.: A randomized trial of deep-brain stimulation for parkinson’s disease. N. Engl. J. Med. 355, 896–908 (2006)

    Article  Google Scholar 

  4. Kringelbach, M.L., Jenkinson, N., Owen, S.L.F., Aziz, T.Z.: Translational principles of deep brain stimulation. Nat. Rev. Neurosci. 8, 623–635 (2007)

    Article  Google Scholar 

  5. Rossi, S., Hallett, M., Rossini, P.M., Pascual-Leone, A.: Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research. Clin. Neurophysiol. 120, 2008–2039 (2009)

    Article  Google Scholar 

  6. Basu, S., Pany, S.S., Bannerjee, P., Mitra, S.: Pulsed magnetic field measurement outside finite length solenoid: experimental results & mathematical verification. J. Electromagn. Anal. Appl. 05, 371–378 (2013)

    Google Scholar 

  7. Ridding, M.C., Rothwell, J.C.: Is there a future for therapeutic use of transcranial magnetic stimulation? Nat. Rev. Neurosci. 8, 559–567 (2007)

    Article  Google Scholar 

  8. Bonmassar, G., Lee, S.W., Freeman, D.K., Polasek, M., Fried, S.I., Gale, J.T.: Microscopic magnetic stimulation of neural tissue. Nat. Commun. 3, 921 (2012)

    Article  Google Scholar 

  9. Lee, S.W., Fried, S.I.: Suppression of subthalamic nucleus activity by micromagnetic stimulation. IEEE Trans. Neural Syst. Rehabil. Eng. 23, 116–127 (2015)

    Article  Google Scholar 

  10. Takemoto, M., Hasegawa, K., Nishimura, M., Song, W.J.: The insular auditory field receives input from the lemniscal subdivision of the auditory thalamus in mice. J. Comp. Neurol. 522, 1373–1389 (2014)

    Article  Google Scholar 

  11. Shibuki, K., Hishida, R., Murakami, H., Kudoh, M., Kawaguchi, T., Watanabe, M., Watanabe, S., Kouuchi, T., Tanaka, R.: Dynamic imaging of somatosensory cortical activity in the rat visualized by flavoprotein autofluorescence. J. Physiol. 549, 919–927 (2003)

    Article  Google Scholar 

  12. Park, H., Bonmassar, G., Kaltenbach, J.A., Machado, A.G., Manzoor, N.F., Gale, J.T.: Activation of the central nervous system induced by micro-magnetic stimulation. Nat. Commun. 4, 2463 (2013)

    Google Scholar 

  13. Sawatari, H., Tanaka, Y., Takemoto, M., Nishimura, M., Hasegawa, K., Saitoh, K., Song, W.-J.J.: Identification and characterization of an insular auditory field in mice. Eur. J. Neurosci. 34, 1944–1952 (2011)

    Article  Google Scholar 

  14. Kozyrev, V., Eysel, U.T., Jancke, D.: Voltage-sensitive dye imaging of transcranial magnetic stimulation-induced intracortical dynamics. Proc. Natl. Acad. Sci. 111, 13553–13558 (2014)

    Article  Google Scholar 

Download references

Acknowledgments

In this work, T.T. was supported by the Magnetic Health Science Foundation (Japan), the Suzuken Memorial Foundation (Japan), and a Grant-in-Aid for Scientific Research (B) (No. 15H02772) and Exploratory Research (No. 15K12091) (Japan). The authors also wish to thank Dr. Kaori Kuribayashi-Shigetomi for her help on the parylene-C coating.

Author information

Authors and Affiliations

  1. Bioengineering and Bioinformatics, Graduate School of Information Science and Technology, Hokkaido University, Kita 14, Nishi 9, Kita-ku, Sapporo, Hokkaido, 060-0814, Japan

    Shunsuke Minusa & Takashi Tateno

Authors
  1. Shunsuke Minusa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Takashi Tateno
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Takashi Tateno .

Editor information

Editors and Affiliations

  1. The University of Tokyo, Tokyo, Japan

    Akira Hirose

  2. Kobe University, Kobe, Japan

    Seiichi Ozawa

  3. Okinawa Institute of Science and Technology Graduate University, Onna, Japan

    Kenji Doya

  4. Nara Institute of Science and Technology, Ikoma, Japan

    Kazushi Ikeda

  5. Kyungpook National University, Daegu, Korea (Republic of)

    Minho Lee

  6. Chinese Academy of Sciences, Beijing, China

    Derong Liu

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer International Publishing AG

About this paper

Cite this paper

Minusa, S., Tateno, T. (2016). Developing an Implantable Micro Magnetic Stimulation System to Induce Neural Activity in Vivo . In: Hirose, A., Ozawa, S., Doya, K., Ikeda, K., Lee, M., Liu, D. (eds) Neural Information Processing. ICONIP 2016. Lecture Notes in Computer Science(), vol 9948. Springer, Cham. https://doi.org/10.1007/978-3-319-46672-9_42

Download citation

  • DOI: https://doi.org/10.1007/978-3-319-46672-9_42

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-46671-2

  • Online ISBN: 978-3-319-46672-9

  • eBook Packages: Computer ScienceComputer Science (R0)

Publish with us

Policies and ethics

Search

Navigation