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MicroRNA Analysis in Acute Lung Injury

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Acute Lung Injury and Repair

Part of the book series: Respiratory Medicine ((RM))

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Abstract

Acute lung injury (ALI) is a complex, heterogeneous disorder with numerous clinical and genetic risk factors. MiRNA are short non-coding segments of RNA which posttranscriptionally modify gene expression by preventing translation of target mRNA. Thousands of miRNA have been identified to date and most have many different gene targets. Thus, miRNA have the capacity to modulate the expression of a large proportion of the human genome. Further, miRNA can be released extracellularly and participate in cell-to-cell communication. Although their ubiquitous and pleiotropic nature make miRNA ideal etiologic effectors in ALI, little is currently known about their role in the injury and repair phases of this disease. In this chapter, miRNA synthesis and function are reviewed as well as the existing knowledge of miRNA’s association with ALI.

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Authors and Affiliations

  1. Division of Pulmonary, Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Suite 816 Clinical Sciences Building, MSC 630, 96 Jonathan Lucas Street, Charleston, South Carolina, 29425, USA

    Andrew J. Goodwin

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Correspondence to Andrew J. Goodwin .

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Editors and Affiliations

  1. Pulmonary, Critical Care, Allergy and Sleep Medicine, Medical University of South Carolina, Charleston, South Carolina, USA

    Lynn M. Schnapp

  2. Division of Rheumatology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA

    Carol Feghali-Bostwick

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Goodwin, A.J. (2017). MicroRNA Analysis in Acute Lung Injury. In: Schnapp, L., Feghali-Bostwick, C. (eds) Acute Lung Injury and Repair. Respiratory Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-319-46527-2_10

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  • DOI: https://doi.org/10.1007/978-3-319-46527-2_10

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