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Development of a Microfluidic Device System Using Adhesive Vinyl Template to Produce Calcium Alginate Microbeads for Microencapsulation of Cells

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Recent Global Research and Education: Technological Challenges

Part of the book series: Advances in Intelligent Systems and Computing ((AISC,volume 519))

Abstract

Microfabrication technique based on microelectronic technology is commonly used to produce microfluidic devices but this technique involves with costly and toxic chemicals. In this paper, we proposed the use of patterned adhesive vinyl template to produce a poly-dimethylsiloxane (PDMS) microfluidic device that was applied to generate microbeads of calcium alginate for microencapsulation of cells. In the microfluidic system, an infusion pump of high flow rate (2000 µl/min) and a commercial syringe pump were used to emulsify the continuous and disperse phases of liquids in forming the microbeads. Microbeads of calcium alginate in the range of 438 ± 38–799 ± 20 µm were successfully produced using this environmental friendly technique.

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References

  1. Hung, L.-H., Lee, A.P.: Microfluidic devices for the synthesis of nanoparticles and biomaterials. J. Med. Biol. Eng. 27(1), 1–6 (2007)

    Google Scholar 

  2. Duncanson, W.J., Lin, T., Abate, A.R., Seiffert, S., Shah, R., David, A.: Microfluidic synthesis of advanced microparticles for encapsulation and controlled release. Lab Chip 12, 2135–2145 (2012)

    Google Scholar 

  3. Nguyen, N.-T., Wereley, S.T.: Fundamentals and Applications of Microfluidics. Artech House, Norwood Incorporation, Boston (2009)

    MATH  Google Scholar 

  4. Björn, S., GPatrick, r., Göran, S.: A thermally responsive PDMS composite and its microfluidic applications. J. microelectromech. syst. 16 (1), 1057–7157 (2007)

    Google Scholar 

  5. Soon, C.F., Thong, K.T., Tee, K.S., Ismail, A.B., Denyer, M., Ahmad, M.K., Kong, Y.H., Vyomesh, P., Cheong, S.C.: A scaffoldless technique for self-generation of three-dimensional keratinospheroids on liquid crystal surfaces. Biotech. Histochem. 91(4), 283–295 (2016)

    Article  Google Scholar 

  6. Wong, S.C., Soon, C.F., Leong, W.Y., Tee, K.S.: Flicking technique for microencapsulation of cells in calcium alginate leading to the microtissue formation. J. Microencapsul. 33(2), 162–172 (2016)

    Google Scholar 

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Acknowledgments

The authors would also like to thank financial support from Research Incentive Grant Scheme (IGSP Vot. U251) and Research Acculturation Grant Scheme (RACE Vot No. 1515) awarded by Malaysia Ministry of Education.

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Authors and Affiliations

  1. Faculty of Electrical and Electronic Engineering, Universiti Tun Hussein Onn Malaysia, 83000, Batu Pahat, Johor, Malaysia

    Chin Fhong Soon, Hiung Yin Yap, Mohd Khairul Ahmad & Kian Sek Tee

  2. Biosensor and Bioengineering Laboratory, MiNT-SRC, Universiti Tun Hussein Onn Malaysia, 83000, Batu Pahat, Johor, Malaysia

    Chin Fhong Soon

  3. School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia

    Siew Hwa Gan

Authors
  1. Chin Fhong Soon
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  2. Hiung Yin Yap
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  3. Mohd Khairul Ahmad
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  4. Kian Sek Tee
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  5. Siew Hwa Gan
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Corresponding author

Correspondence to Chin Fhong Soon .

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Editors and Affiliations

  1. Institute of Metrology and Biomedical En, Warsaw University of Technology Institute of Metrology and Biomedical En, Warsaw, Poland

    Ryszard Jabłoński

  2. Institute of Metrology and Biomedical En, Warsaw University of Technology Institute of Metrology and Biomedical En, Warsaw, Poland

    Roman Szewczyk

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Soon, C.F., Yap, H.Y., Ahmad, M.K., Tee, K.S., Gan, S.H. (2017). Development of a Microfluidic Device System Using Adhesive Vinyl Template to Produce Calcium Alginate Microbeads for Microencapsulation of Cells. In: Jabłoński, R., Szewczyk, R. (eds) Recent Global Research and Education: Technological Challenges. Advances in Intelligent Systems and Computing, vol 519. Springer, Cham. https://doi.org/10.1007/978-3-319-46490-9_63

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  • DOI: https://doi.org/10.1007/978-3-319-46490-9_63

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-319-46489-3

  • Online ISBN: 978-3-319-46490-9

  • eBook Packages: EngineeringEngineering (R0)

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